Suzuki, M., Aru, J. & Larkum, M.E. (2021) Double-µPeriscope, a tool for multi-layer optical recordings, optogenetic stimulations or both.
eLife 10:e72894. https://doi.org/10.7554/eLife.72894
Aru, J., Suzuki, M. & Larkum, M.E. (2020) Cellular mechanisms of conscious processing.
Trends in Cognitive Sciences 24(10):814-825. https://doi.org/10.1016/j.tics.2020.07.006
Suzuki, M. & Larkum, M.E. (2020) General anesthesia decouples cortical pyramidal neurons.
Cell 180(4):666-676. https://doi.org/10.1016/j.cell.2020.01.024
Suzuki, M. & Larkum, M.E. (2017) Dendritic calcium spikes are clearly detectable at the cortical surface.
Nature Communications 8(1):276. http://doi.org/10.1038/s41467-017-00282-4
Suzuki, M. & Gottlieb, J. (2013) Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe.
Nature Neuroscience 16(1):98-104. http://dx.doi.org/10.1038/nn.3282
In 2020 Jaan Aru, Matthew Larkum and I formulated the Dendritic Integration Theory (DIT; Aru, Suzuki & Larkum, Trends Cogn Sci 2020). The theory posits that apical dendrites of cortical layer 5 pyramidal neurons play a central role in integrating large-scale cortico-cortical and thalamo-cortical loops that are essential for conscious perception. Unlike many abstract theories previously proposed, a distinguishing feature of DIT is that the theory spotlights a specific cellular mechanism—pyramidal cell dendrites—as the fulcrum at which these two apparently-orthogonal loops intersect.
DIT makes a lot of testable predictions and my team will experimentally test these predictions using novel micro-optical tools (see below). The research questions of particular relevance to DIT include, but not limited to:
My previous studies demonstrated that novel micro-optical tools enabled unprecedented experiments and led to unexpected findings (Suzuki & Larkum, Nat Commun 2017; Suzuki & Larkum, Cell 2020; Suzuki et al., eLife 2021). My team aims to further develop novel tools that have the potential to enable us to make ground-breaking discoveries.