Prof. dr. P.J. (Paul) Lucassen
Faculty of Science
Swammerdam Institute for Life Sciences
Area of expertise: Plastcity, adult neurogenesis, stem cells, cognition, anxiety, resilience, (early life) stress, nutrition, exercise, environmental enrichment, programming of brain structure and function, hippocampus, hypothalamus, depression, dementia.
Visiting address
- Science Park 904
- Room number: C3.270
Postal address
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Postbus 94246
1090 GE Amsterdam
Contact details
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Lucassen group; "Brain Plasticity".
Brain Plasticity Group may 2025 General information; research topics
Our main interest is brain plasticity in relation to (early) stress and disease. We focus on the regulation of adult neurogenesis and other forms of (structural/synaptic/functional) plasticity and their relevance for cognition, depression and dementia. Neurogenesis is prominent particularly during early development, and our primary focus is effects of early stress on (development of) hippocampal structure and function. This brain structure is very sensitive to stress hormone action, implicated in learning and memory and affected in several disease conditions including depression, suicide and dementia. The hippocampus is furthermore unique as it contains stem cells that continue to generate new neurons in adult animals, including humans, a process called "adult neurogenesis".
Key interest is the functional relevance of adult neurogenesis for brain function. We hypothesize that e.g. stress-induced reductions in the number of newborn neurons is determined during early development and will interfere with the role of the hippocampus e.g. in cognition, depression and dementia and in the negative feedback of the HPA-axis in adult life. We further study how such deficits can be influenced and possibly ameliorated by means of early diet, antidepressant treatment, or physical or cognitively challenging events such as life long learning and exercise.Our groups is further well embedded and represented in various (inter)national consortia and organizations, including;
-Amsterdam Neuroscience (https://www.amsterdamumc.org/en/research/institutes/amsterdam-neuroscience.htm),
-the Graduate School Neurosciences Amsterdam (https://onwar.nl),
-Stress-NL (https://stress-nl.nl),
-the Center for Urban Mental Health https://www.centreforurbanmentalhealth.com),
-Amsterdam Brain & Cognition (https://abc.uva.nl),
-the Dutch Neuroscience Meeting (https://dnm25.azuleon.org),
-SIGO (https://jjgroenstichting.nl),
-the Federation of European Neuroscience FENS (https://www.fens.org), and
-the European College of Neuropsychopharmacology ECNP (http://www.ecnp.eu).
I further have a leading role in the Zon-MW funded NMCB biobank consortium on the chronic fatigue syndrome ME/CFS (https://nmcb.eu) and the Zon-MW funded Memorabel consortium on Alzheimer's disease; Mechanisms of Dementia (MODEM; https://modemproject.nl ).
Our group further has a strong connection with the Netherlands Institute for Neuroscience (NIN; http://www.nin.knaw.nl) and Netherlands Brain bank (https://www.brainbank.nl), via collaborations with a.o. Dick Swaab, Evgenia Salta and Inge Huitinga, who is appointed as special chair on NeuroImmunology and Multiple Sclerosis in our BP group.
With Inge Huitinga and Mario van der Stelt (Leiden), I am co-recipient of the 2024 NWO Gravitation grant 'Institute for Chemical Neuroscience (ICNS)', a 10 year funding program with 9 groups in Holland, in which we will combine multi-omics analysis on the human brain tissues with machine learning and AI-supported analysis of the patient data, and advanced chemical approaches to idenfity new leads and molecular pathways that underlie symptoms of psychiatric diseases. Ultimately, we hope this will help improve diagnosis, prognosis and hopefully promote new therapeutic approaches for various neuropsychiatric brain disorders. For more info, see; https://i-cns.nl.
Selected recent key publications;
- PJ Lucassen, CP Fitzsimons, A Korosi, M Joels, C Belzung and DN Abrous. Stressing new neurons into depression? Mol Psychiatry 2013 18: 396-397.
- C P Fitzsimons, L W A van Hooijdonk, M Schouten, I Zalachoras, V Brinks, T Zheng, T G Schouten, D J Saaltink, T Dijkmans, D A Steindler, J Verhaagen, F J Verbeek, P J Lucassen, E R de Kloet, O C Meijer, H Karst, M Joels, M S Oitzl and E Vreugdenhil. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Mol Psychiatry 2013 18: 993-1005.
- Paul J. Lucassen, Eva F.G. Naninck, Johannes B. van Goudoever, Carlos Fitzsimons, Marian Joels and Aniko Korosi. Perinatal programming of hippocampal structure and function; emerging roles of stress, neurogenesis, epigenetics and early nutrition. Trends in Neuroscience, 2013.
- PJ Lucassen, N Sousa, OFX Almeida, G Rajkowska, J Pruessner, DF Swaab and B Czeh. Neuropathology of Stress. Acta Neuropathologica, 2014.
- A. Schrantee, G.H. Tamminga, C. Bouziane, M.A. Bottelier, E.E. Bron, H.J.M. Mutsaerts, K. Zwinderman, I.R. Groote, S.A.R.B. Rombouts, R.J.L. Lindauer, W. Niessen, S. Klein, B.C. Opmeer, F. Boer, P.J. Lucassen, S.L. Andersen, H.M. Geurts and L. Reneman. A randomized trial on the age-dependency of methylphenidate effects on the human dopamine system. JAMA Psychiatry, 2016; 73(9):955-62.
- Yam KY, E.F.G. Naninck, M.R. Abbink, S.E. la Fleur, L. Schipper, J.C. van den Beukel, A. Grefhorst, A. Oosting, E.M. van der Beek, P.J. Lucassen, A. Korosi. Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology 77 (2017) 186–195.
- SL Lesuis, S Weggen, S Baches, PJ Lucassen, HJ Krugers. Early life stress accelerates amyloid pathology and cognitive decline in an Alzheimer mouse model, which can be rescued by briefly blocking glucocorticoid receptors at middle age. Transl. Psych. 2018.
- Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018.
- SL Lesuis, Hoeijmakers L, Korosi A, de Rooij SR, Swaab DF, Kessels HW, Lucassen PJ, Krugers HJ. Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimers Res Ther. 2018.
- J Zhao, PJ Lucassen, DF Swaab. 2019. Suicide is a confounder in postmortem studies on depression. Biol. Psych. 2019.
- Schouten M, Bielefeld P, Passchier EMJ, Garcia-Corzo L, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, de Vries HE, Schwarzacher SW, De Pietri Tonelli D, Toni N, Trejo JL, Mira H, Encinas JM and Fitzsimons CP. Circadian Glucocorticoid Oscillations Preserve a Population of Adult Hippocampal Neural Stem Cells in the Aging Brain. Mol. Psych. 2020.
- PJ Lucassen, N Toni, G Kempermann, J Frisen, FH Gage and DF Swaab. Limits to human neurogenesis - really? Mol.Psych. 2020.
- Pu Hu, AM Van Dam, Yu Wang, Paul J. Lucassen, Jiang-Ning Zhou. Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms. Neuroscience and Biobehavioral Reviews 112 (2020) 376–391.
- Sharif A, Fitzsimons CP, Lucassen PJ. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. Handb Clin Neurol. 2021.
- Sylvie L. Lesuis, Niek Brosens, Nathalie Immerzeel, Rolinka J. van der Loo, Miodrag Mitrić, Pascal Bielefeld, Carlos P. Fitzsimons, Paul J. Lucassen, Steven A. Kushner, Michel C. van den Oever, Harm J. Krugers. Glucocorticoids promote fear generalization by increasing the size of a dentate gyrus engram cell population. Biological Psychiatry, 2021.
-van der Wal JM, van Borkulo CD, Deserno MK, Breedvelt JJF, Lees M, Lokman JC, Borsboom D, Denys D, van Holst RJ, Smidt MP, Stronks K, Lucassen PJ, van Weert JCM, Sloot PMA, Bockting CL, Wiers RW. On the urgency of advancing urban mental health research: a complexity science approach. Lancet Psychiatry, 2021.
- JR Homberg et al., The continued need for animals to advance brain research. Neuron 2021.
-Du Preez A, Lefèvre-Arbogast S, Houghton V, (..), Thuret S. The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer’s & Dementia, 2021.
- Paul Lucassen is co-editor with Dick F. Swaab, Felix Kreier, Ahmad Salehi and Ruud M. Buijs, of the Handbook of Clinical Neurology series (4 volumes) on The Human Hypothalamus, published by Elsevier, 2021.
- Brinkhof LP, Huth KBS, Murre JMJ, de Wit S, Krugers HJ, Ridderinkhof KR. The Interplay Between Quality of Life and Resilience Factors in Later Life: A Network Analysis. Front Psychol. 2021.
- Buurstede JC, Umeoka EHL, da Silva MS, Krugers HJ, Joëls M, Meijer OC. Application of a pharmacological transcriptome filter identifies a shortlist of mouse glucocorticoid receptor target genes associated with memory consolidation. Neuropharmacology. 2022.
- Brinkhof LP, Ridderinkhof KR, van de Vijver I, Murre JMJ, Krugers HJ, de Wit S. Psychological Coping and Behavioral Adjustment Among Older Adults in Times of COVID-19: Exploring the Protective Role of Working Memory and Habit Propensity. J Adult Dev. 2022.
- Zhang L, Paul J. Lucassen, Evgenia Salta, Peter D.E.M. Verhaert, Dick F. Swaab. Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough. Neurosci & Biobehav Reviews, volume 132, p 542-552, 2022.
- Yshii L, Pasciuto E, Bielefeld P (..), Fitzsimons CP, Holt MG, Liston A. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunol. 2022.
- Merabet N, Paul J. Lucassen, Loes Crielaard, Karien Stronks, Rick Quax, Peter M.A. Sloot, Susanne E. La Fleur, Mary Nicolaou. How exposure to chronic stress contributes to the development of type 2 diabetes: a complexity science approach. Frontiers in NeuroEndocrinology, 2022.
- Salta E, Lazarov O, Fitzsimons CP, Tanzi R, Lucassen PJ, Choi SH. Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell Stem Cell 2023.
- Tosoni G, Ayyildiz D, Bryois J, Macnair W, Fitzsimons CP, Lucassen PJ, Salta E. Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? Neuron 2023.
- Loef D, Tendolkar I, van Eijndhoven P, Hoozemans J, Oudega M, Rozemuller A, Lucassen PJ, Dols A, Dijkstra A. Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients. Translational Psychiatry 2023.
-Juncker HG, Naninck EFG, van Keulen BJ, Harinck JE, Schipper L, Lucassen PJ, van Goudoever JB, de Rooij SR, Korosi A. Maternal stress is associated with higher protein-bound amino acid concentrations in human milk. Front Nutr. 2023.
- Brosens N, Samouil D, Stolker S, Katsika EV, Weggen S, Lucassen PJ, Krugers HJ. Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice. J Alzheimers Dis. 2023.
- Brinkhof LP, Ridderinkhof KR, Murre JMJ, Krugers HJ, de Wit S. Improving goal striving and resilience in older adults through a personalized metacognitive self-help intervention: a protocol paper. BMC Psychol. 2023.
- Kotah JM, Mandy S.J. Kater, Niek Brosens, Sylvie L. Lesuis, Roberta Tandari, Thomas M. Blok, Luca Marchetto, Ella Yusaf, Frank Koopmans, August B. Smit, Paul J. Lucassen, Harm J. Krugers, Mark H.G. Verheijen, Aniko Korosi. Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism. Alzheimer’s & Dementia, 2024.
- Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Paul J. Lucassen, Peter W. Nathanielsz, Elly M. Hol, Eleonora M.A. Aronica, Waljit S. Dhillo, Gerben Meynen, Dick F. Swaab. Progesterone receptor distribution in the human hypothalamus and its association with suicide. Acta Neuropathol Commun. 2024.
- Brosens N, Lesuis SL, Rao-Ruiz P, van den Oever MC, Krugers HJ. Shaping Memories via Stress: A Synaptic Engram Perspective. Biol Psychiatry. 2024.
- Dohm-Hansen S, English JA, Lavelle A, Fitzsimons CP, Lucassen PJ, Nolan YM. The 'middle-aging' brain. Trends Neurosci. 2024
- Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Durá I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP. Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Commun. 2024.
- Lucassen PJ, Korosi A, de Rooij SR, Smit AB, Van Dam AM, Daskalakis NP, Van Kesteren RE, Verheijen MHG, Lesuis SL, Kessels HW, Krugers HJ. How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms. Biol Psychiatry. 2025.
-Polzer Oliver, Kinnloch E, Lucassen PJ, Salta E, Fitzsimons CP. Cross-analysis of single-cell transcriptomic datasets reveals conserved neurogenic gene signatures and new insights into neural stem cell aging. Aging Cell 2025.
- Maria Carrigan, Diana I. Bocancea, Sven van der Lee, Frederik Barkhof, Nico Tesi, Anita van Loenhoud, Jacob Vogel, Paul J. Lucassen, Wiesje van der Flier, Harm Krugers, Rik Ossenkoppele. A novel approach to resilience and its links with education and Alzheimer’s disease genetics. Alzheimer’s Dementia 2025.
Brain Plasticity group 2023 -
Recent lectures, outreach, etc
Lectures delivered;
2015;
1. Invited Lecture "Structural plasticity in relation to (early) stress, nutrition and depression." Host; Dr. S. Schwarzacher, Dept Klinische NeuroAnatomie, Goethe Universitat, Frankfurt am Main, Germany, 15 Jan 2015.
2. Lecture; 'Trends in Alzheimer's disease research, a personal perspective' at the ISAO Meet and Greet meeting, Jaarbeurs Utrecht, 28 Jan 2015.
3. Invited Lecture "Effects of early life stress and nutrition on adult hippocampal plasticity and function" at MRC Social, Genetic and Developmental Psychiatry Centre (host; Dr Geoff Bird), Institute of Psychiatry, King's College London, United Kingdom, 16 Feb 2015.
4. Lecture 'Plasticity in relation to stress and neurogenesis'. Host; Dr Sandrine Thuret, King's College London, United Kingdom, Febr 17th 2015.
5. Invited Lecture 'Structural plasticity in relation to (early) stress, depression and dementia', at the Department of Fundamental Neurosciences, University of Lausanne (host; Dr. N. Toni), Lausanne, Switzerland, 4th march 2015.
6. Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression', at the Department of Anatomy, ETH (hosts; Dr I Amrein, M Van Dijk), Zurich, Switzerland, 4th March 2015.
7. Invited Lecture "Structural plasticity in relation to (early) stress and depression", at the session on "Structural dynamics of adult neurogenesis" at the 17th International Neuroscience Winter Conference (host; Dr. S. Schwarzarcher), Solden, Switzerland, 10 April 2015.
8. Lecture "Structural plasticity, (early) stress, antidepressants and major depression", at the minisymposium on the occasion of the visit of Dr Snezana Milanovic at the AMC, Amsterdam, 28 may 2015.
9. Invited Lecture 'Application of MRS as tool to measure adult neurogenesis in the live human brain', ABC conference, Theater De Brakke Grond, Amsterdam, 1 Juni 2015.
10. Invited lecture 'Science matters; stress & stem cells', at the Biomedical Symposium Radboud Universiteit Nijmegen, 1 juli 2015.
11. Invited lecture "Hippocampal plasticity in relation to (early) stress, nutrition and depression', at the Adult Neurogenesis meeting, Provence, France, 17 Sept 2015.
12. ECNP supported, plenary lecture at the 8th Simposium Psiquiatria de Braga; 'Structural plasticity in relation to early stress, nutrition and depression' at the University of Minho, Braga, Portugal, Oct 1st 2015.
13. Invited lecture’ ‘'Hippocampal plasticity in relation to early stress, nutrition and depression’ at the symposium on PTSD in Bristol, UK, hosts; Prof.Dr. Hans Reul, Prof.Dr. Astrid Linthorst, 16/17 November 2015.
14. Invited Plenary Lecture "Nieuwe cellen in het volwassen brein; stamcellen en sport" (laymen talk in Dutch) at the Opening Symposium of the "Exercise and the brain" week (supported by the Cruyff foundation) at the Amstelveen College, Amstelveen The Netherlands, 15 Dec 2015.2016;
15. Invited lecture 'Plasticity changes in relation to (early) stress, depression and dementia, at the Danish Academy, Aarhus University, Aarhus, Denmark, 14 jan 2016.
16. Invited lecture 'Hippocampal plasticity in relation to early stress, nutrition and depression", at the 2016 IBRO Workshop, organized by the Hungarian Academy of Sciences, opening lecture of the symposium “Behavioral, Endocrine and Neuropathological Consequences of Stressful Life Events”. Budapest, Hungary, January 22nd, 2016.
17. Invited Plenary lecture 'Ins and outs of Adult Neurogenesis', at the 5th Biennial ICCTF Meeting, Netherlands Cancer Institute Amsterdam, 15th March 2016 (host; Dr. S. Schagen).
18. Invited participant/discussant for the Round Table Expert meeting on Early Life Stress, at the 'Neurobiology of Stress' conference, 12-14 april in Newport Beach, Irvine, USA (host; Prof.Dr. T. Baram).
19. Invited lecture 'Structural plasticity and neurogenesis in relation to (early) stress, depression and dementia', Department of Neuroscience, Universitat de Valencia, Valencia, Spain, April 25th 2016 (host; Dr. J. Nacher).
20. Invited Plenary Lecture "New neurons in adult brains; an emerging substrate for brain plasticity programmed during early life", at the Spring conference on 'Neuroplasticity & Cognitive Reserve' of the Dutch Association for NeuroPsychology, 13 may 2016, (host; Prof.Dr. B. Schmand), Muntgebouw Utrecht, the Netherlands.
21. Invited 'University of Amsterdam' lecture (in Dutch); 'Nieuwe zenuwcellen voor het volwassen brein', at the Universiteitsdag, Oudemanhuispoort, June 4th 2016, Amsterdam.
22. Invited talk 'Early stress and neurogenesis; the importance of nutritional programming for later cognition', at the 3rd EUROGENESIS meeting, July 12-15th 2016, Bordeaux, France.
23. Invited talk "(Early) stress effects on neurogenesis and plasticity", at the meeting of the British Psychiatry Association (BAP), Brighton UK, 17-20 July 2016.
24. Invited lecture; "Hippocampal plasticity, (early) stress and depression" at the ISPNE meeting in Miami, USA. 12 Sept 2016.
25. Invited Keynote speaker on 'Neurogenesis and Alzheimer", University Maastricht, 2 Dec 2016.
2017;
26. Invited Lecture "Structural hippocampal plasticity and neurogenesis in relation to dementia", at the Alzheimer Center of the VUMC Amsterdam, hosts; PJ Visser, P Scheltens, W van der Flier, 20 Jan 2017.
27. Lecture 'An overview of Alzheimer research; the state of the affairs (in Dutch)", at the Netherlands Institute for Brain Research NIN, 7 Feb 2017.
28. Invited Lecture 'Structural plasticity in relation to depression and dementia', at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark (host; Prof. Dr. B. Finsen), Odense, Denmark, 9 March 2017.
29. Invited lecture on 'Regulation of neurogenesis by stress and antidepressants' at the Varna meeting on 'Adult primate neurogenesis', Varna, Bulgaria, 20 may 2017.
30. Invited Lecture on 'Our brain under stress (in Dutch)', at the Pawlik Congres – 'Presteren onder Druk', georganiseerd door Pawlik Consultants, Dauphine, Amsterdam, 30 may 2017.
31. Moderator/chair/introductory talk of the session on 'Exercise and psychiatric disease; should patients take the challenge?' at the ECNP meeting in Paris, France, Sept 2017.
32. Invited Lecture ‘New neurons in, and for, adult brains; environmental regulation and functional roles’, within the framework of an ERASMUS exchange program at the Athens University, 24th October 2017.
33. Invited Lecture ‘Stem cells, hippocampal neurogenesis, stress and depression’, at the Dept of Psychiatry, University of Athens (host; Dr M. Panayatocopolou), 25th Oct 2017.
34. Invited laymens talk on ‘Our brain under stress’ (in Dutch), for the crowdfunded project on ‘Stress and the heart’, awarded to Dr A. Schrantee’ at the AMC Amsterdam, 31 Oct 2017.2018;
35. Invited lecture on “Effects of early life stress and nutrition on later brain plasticity and disease vulnerability” at the MQ mental health meeting, London, 2 feb 2018.
36. Invited lecture “Brain plasticity in relation to (early) stress, nutrition and depression’, at the Institute Italiano di Tecnologica in Genova, Italy (host; Dr Davide die Pietri Tonelli), 17 May 2018.
37. Invited Lecture “Neurogenesis, (early) stress and depression’ at the Dutch Neuroscience Meeting, Lunteren, 7th June 2018.
38. Invited lecture ‘Highlights in Dementia’ at the ECNP meeting in Barcelona, 7 Oct 2018.
39. Opening talk at the session ‘Update on Huntington’s and Parkinson’s disease treatment’, at the ECNP meeting, 9th Oct 2018.
40. Lecture on ‘Brain Plasticity’ at the University of Edinburgh, Scotland (host Prof.Dr. J. Seckl), 26th Oct 2018.2019;
41. Invited Lecture; ‘Brain plasticity in relation to early life stress, nutrition and major depression’, on the occasion of the PhD viva of Danka Kozareva at University College Cork, Ireland, hosts Dr. Y Nolan and Prof.Dr. J Cryan, 28th Jan 2019.
42. Invited Lecture; ‘Brain plasticity and neurogenesis in relation to early life stress, nutrition, depression and dementia’, at Neuroscience & Mental Health Research Institute, School of Biosciences, Cardiff University, Cardiff, UK, host Prof.Dr. S Trent, Prof.Dr. J Hall, 14th Feb 2019.
43. Invited Lecture as part of UvA Health Week; ‘What does stress do to your brain?’ UvA, Science Park, 14th May 2019.
44. Invited Lecture ‘Brain Plasticity in relation to (early) stress, nutrition and depression’. Host; Prof.dr. Eleanor Coffey, Turku Centre for Biotechnology, University of Turku and Department of Biosciences, Åbo Akademi University Åbo, Turku, Finland, 17th May 2019.
45. Lecture ‘Brain plasticity in relation to early life stress, nutrition and dementia”, Eurogenesis meeting 14th June 2019, Bordeaux, France.46. Invited Lecture on; ‘Cognitive reserve and plasticity from a neurobiological perspective; focus on early life’ at the Cognitive Reserve Symposium at the Veranda, host Dr Rik Ossenkoppele and Prof.Dr. W vd Flier, Alzheimer Centrum, Amsterdam, 18 sept 2019.
47. Invited talk on; ‘Brain plasticity in relation to (early life) stress, nutrition and dementia’, host; Prof.Dr. P. Riederer, International WASAD congress, Wuerzburg Germany, 5 Oktober 2019.
48. Invited lecture; ‘Neurobiology of Alzheimer’s disease; recent developments’, (host Dr. I. Philippens) at TNO BPRS Rijswijk, 19 nov 2019.
49. Outreach lecture (in Dutch) in the framework of the ‘Inspiratie week’; ‘Hersenonderzoek in de praktijk', for 3 HV students, Montessori Scholengemeenschap Amsterdam, 21 Nov 2019.
50. Outreach Lecture (in Dutch) on 'What is brain research about these days?', for 4 VWO students at the Herman Wesselink College in Amstelveen, 18 Dec 2019.
2020;
51. Invited talk on; ‘Brain plasticity, (early) stress and Alzheimer’s disease’, for the ZONMW Memorabel Program committee meeting, at the VUMC Amsterdam, 22-1-2020.
52. Invited public lecture (in Dutch) on ‘Stress en het brein’, for the Amsterdam Broodfonds, Media Monks, Houthaven Amsterdam, 26 March, 2020 (cancelled).
53. Invited lecture (online) on; “Neurobiology of Alzheimer’s disease’ at the Amsterdam Brain & Cognitive sciences Summer School on the Aging Brain, entitled; ‘Gray Matters’, 19 June 2020.
54. Invited lecture (online) on; ‘Brain plasticity in relation to early life stress and nutrition,’ at the online version of the ECNP conference, 13 Sept 2020.
55. Invited Lecture on; ‘Brain plasticity, (early) stress, nutrition and Alzheimer’s disease’, at the afdeling Epidemiology and Biostatistics, Erasmus University Rotterdam (online), host; Dr. M. Mens, prof.dr. Ikram. Online 28 sep 2020.56. 'Brain Plasticity; stress and disease’. UvA, feb 2023.
57. ‘Breaking the vicious cycle; preventing intergenerational transmission of stress and mental health problems’, Inspiring Generations meeting, Healthy Future event UvA March 2023.
58. Top paper session on 'Neurodegeneration', at the yearly meeting of the European College of Neuropsychopharmacology, Barcelona, October 2023.
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Publications
- key publications (17)
- refereed (241)
- academic (11)
- professional (5)
- other output (1)
- recognitions (219)
- supervised theses (28)
- datasets (5)
2025
Lucassen, P. J., Korosi, A., de Rooij, S. R., Smit, A. B., Van Dam, A.-M., Daskalakis, N. P., Van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W., & Krugers, H. J. (2025). How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms. Biological Psychiatry, 97(4), 372-381. https://doi.org/10.1016/j.biopsych.2024.11.007 [details]
2024
- Bielefeld, P., Martirosyan, A., Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I., Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., ... Fitzsimons, C. P. (2024). Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 15, Article 5222. https://doi.org/10.1038/s41467-024-49299-6 [details]
2023
- Loef, D., Tendolkar, I., van Eijndhoven, P. F. P., Hoozemans, J. J. M., Oudega, M. L., Rozemuller, A. J. M., Lucassen, P. J., Dols, A., & Dijkstra, A. A. (2023). Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients. Translational Psychiatry, 13, Article 355. https://doi.org/10.1038/s41398-023-02658-1 [details]
- Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. (2023). Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell Stem Cell, 30(2), 120-136. https://doi.org/10.1016/j.stem.2023.01.002 [details]
2022
- Du Preez, A., Lefèvre-Arbogast, S., González-Domínguez, R., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust-Lima, C., Pallàs, M., Sánchez-Pla, A., Urpi-Sardà, M., Ruigrok, S. R., Altendorfer, B., Aigner, L., Lucassen, P. J., Korosi, A., Manach, C., ... Thuret, S. (2022). Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study. Molecular Psychiatry, 27(8), 3425–3440. https://doi.org/10.1038/s41380-022-01644-1 [details]
2021
- Kaiser, A., Bottelier, M. A., de Ruiter, M. B., Solleveld, M. M., Tamminga, H. G. H., Bouziane, C., Geurts, H. M., Lindauer, R. J. L., Kooij, J. J. S., Lucassen, P. J., Schrantee, A., & Reneman, L. (2021). Effects of prolonged methylphenidate treatment on amygdala reactivity and connectivity: a randomized controlled trial in stimulant treatment-naive, male participants with ADHD. Psychoradiology, 1(3), 152-163. https://doi.org/10.1093/psyrad/kkab013 [details]
- Lesuis, S. L., Brosens, N., Immerzeel, N., van der Loo, R. J., Mitrić, M., Bielefeld, P., Fitzsimons, C. P., Lucassen, P. J., Kushner, S. A., van den Oever, M. C., & Krugers, H. J. (2021). Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry, 90(7), 494-504. https://doi.org/10.1016/j.biopsych.2021.04.010 [details]
2020
- Lucassen, P. J., Fitzsimons, C. P., Salta, E., & Maletic-Savatic, M. (2020). Adult neurogenesis, human after all (again): Classic, optimized, and future approaches. Behavioural Brain Research, 381, Article 112458. https://doi.org/10.1016/j.bbr.2019.112458 [details]
- Lucassen, P. J., Toni, N., Kempermann, G., Frisen, J., Gage, F. H., & Swaab, D. F. (2020). Limits to human neurogenesis-really? Molecular Psychiatry, 25(10), 2207-2209. https://doi.org/10.1038/s41380-018-0337-5 [details]
2019
- Zhao, J., Lucassen, P. J., & Swaab, D. F. (2019). Suicide Is a Confounder in Postmortem Studies on Depression. Biological Psychiatry, 86(10), e37-e40. https://doi.org/10.1016/j.biopsych.2019.04.015 [details]
2018
- Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Gould, E., Hen, R., Abrous, D. N., Toni, N., Schinder, A. F., Zhao, X., Lucassen, P. J., & Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004 [details]
- Lesuis, S. L., Hoeijmakers, L., Korosi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W., Lucassen, P. J., & Krugers, H. J. (2018). Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy, 10, Article 95. https://doi.org/10.1186/s13195-018-0422-7 [details]
2017
- Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2017). Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, behavior, and immunity, 63, 160-175. https://doi.org/10.1016/j.bbi.2016.12.023 [details]
2016
- Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H.-JMM., Zwinderman, A. H., Groote, I. R., Rombouts, S. A. R. B., Lindauer, R. J. L., Klein, S., Niessen, W. J., Opmeer, B. C., Boer, F., Lucassen, P. J., Andersen, S. L., Geurts, H. M., & Reneman, L. (2016). Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clincal Trial. JAMA Psychiatry, 73(9), 955-962. https://doi.org/10.1001/jamapsychiatry.2016.1572 [details]
2015
- Bolijn, S., & Lucassen, P. J. (2015). How the body talks to the brain; peripheral mediators of physical activity-induced proliferation in the adult hippocampus. Brain Plasticity, 1(1), 5-27. https://doi.org/10.3233/BPL-150020 [details]
- Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015). Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology, 7(9), Article a021303. https://doi.org/10.1101/cshperspect.a021303 [details]
2000
- Lucassen, P. J., Negoescou, A., Labat-Moleur, F., & van Lookeren Campagne, M. (2000). Microwave enhanced in situ end labelling of apoptotic cells in tissue sections; pitfalls and possibilities. In J. G. C.R. Taylor S.R. Shi (Ed.), Antigen Retrieval Techniques (Biotechniques series Eaton Publishing.
2025
- Altendorfer, B., Poupardin, R., Lefèvre-Arbogast, S., Manach, C., Low, D. Y., Urpi-Sarda, M., Andres-Lacueva, C., González-Domínguez, R., Felder, T. K., Tevini, J., Zattoni, M., Koller, A., Schmidt, R., Lucassen, P. J., Ruigrok, S. R., de Lucia, C., Du Preez, A., Helmer, C., Neuffer, J., ... Aigner, L. (2025). Blood serum from individuals with Alzheimer's disease alters microglial phagocytosis in vitro. Neural Regeneration Research. Advance online publication. https://doi.org/10.4103/NRR.NRR-D-24-01287
- Carrigan, M., Bocancea, D. I., Vogel, J., van Loenhoud, A. C., Tesi, N., Barkhof, F., Lucassen, P. J., van der Flier, W. M., Krugers, H. J., Van der Lee, S. J., & Ossenkoppele, R. (2025). A novel approach to resilience and its links with education and Alzheimer's disease genetics. Alzheimer's & Dementia, 21(7), Article e70379. https://doi.org/10.1002/alz.70379 [details]
- Lucassen, P. J., Korosi, A., de Rooij, S. R., Smit, A. B., Van Dam, A.-M., Daskalakis, N. P., Van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W., & Krugers, H. J. (2025). How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms. Biological Psychiatry, 97(4), 372-381. https://doi.org/10.1016/j.biopsych.2024.11.007 [details]
- Polzer, O., Kinloch, E., Lucassen, P. J., Salta, E., & Fitzsimons, C. P. (2025). Cross-Analysis of Single-Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging. Aging Cell, e70106. Advance online publication. https://doi.org/10.1111/acel.70106
- Shiba, A., Hardonk, M. H., Foppen, E., Kool, T., la Fleur, S. E., Lucassen, P. J., Yi, C.-X., Stenvers, D. J., Mul, J. D., & Kalsbeek, A. (2025). Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat. Journal of Circadian Rhythms, 23, Article 7. https://doi.org/10.5334/jcr.257 [details]
2024
- Bielefeld, P., Martirosyan, A., Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I., Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., ... Fitzsimons, C. P. (2024). Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 15, Article 5222. https://doi.org/10.1038/s41467-024-49299-6 [details]
- Caruso, M. G., Nicolas, S., Lucassen, P. J., Mul, J. D., O'Leary, O. F., & Nolan, Y. M. (2024). Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models. Brain Plasticity, 9(1-2), 43-73. https://doi.org/10.3233/BPL-230157 [details]
- Dohm-Hansen, S., English, J. A., Lavelle, A., Fitzsimons, C. P., Lucassen, P. J., & Nolan, Y. M. (2024). The 'middle-aging' brain. Trends in Neurosciences, 47(4), 259-272. https://doi.org/10.1016/j.tins.2024.02.001 [details]
- Du Preez, A., Lefèvre-Arbogast, S., González-Domínguez, R., Houghton, V., de Lucia, C., Lee, H., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust-Lima, C., Pallàs, M., Sánchez-Pla, A., Urpi-Sardà, M., Ruigrok, S. R., Altendorfer, B., Aigner, L., Lucassen, P. J., Korosi, A., ... Thuret, S. (2024). Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing. Age and Ageing, 53(Supplement 2), ii47-ii59. https://doi.org/10.1093/ageing/afae042 [details]
- Franzoi, D., Bockting, C. L., Bennett, K. F., Odom, A., Lucassen, P. J., Pathania, A., Lee, A., Brouwer, M. E., van de Schoot, R., Wiers, R. W., & Breedvelt, J. J. F. (2024). Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review. SSM - Population Health, 25, Article 101575. https://doi.org/10.1016/j.ssmph.2023.101575 [details]
- Geertsema, J., Kratochvil, M., González-Domínguez, R., Lefèvre-Arbogast, S., Low, D. Y., Du Preez, A., Lee, H., Urpi-Sarda, M., Sánchez-Pla, A., Aigner, L., Samieri, C., Andres-Lacueva, C., Manach, C., Thuret, S., Lucassen, P. J., & Korosi, A. (2024). Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice. Neurobiology of Stress, 31, Article 100641. https://doi.org/10.1016/j.ynstr.2024.100641 [details]
- Kotah, J. M., Kater, M. S. J., Brosens, N., Lesuis, S. L., Tandari, R., Blok, T. M., Marchetto, L., Yusaf, E., Koopmans, F. T. W., Smit, A. B., Lucassen, P. J., Krugers, H. J., Verheijen, M. H. G., & Korosi, A. (2024). Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism. Alzheimer's & Dementia, 20(3), 1637-1655. https://doi.org/10.1002/alz.13569 [details]
- Tor-Roca, A., Sánchez-Pla, A., Korosi, A., Pallàs, M., Lucassen, P. J., Castellano-Escuder, P., Aigner, L., González-Domínguez, R., Manach, C., Carmona, F., Vegas, E., Helmer, C., Feart, C., Lefèvre-Arbogast, S., Neuffer, J., Lee, H., Thuret, S., Andres-Lacueva, C., Samieri, C., & Urpi-Sarda, M. (2024). A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort Study. Molecular nutrition & food research, 68(13), Article e2300271. https://doi.org/10.1002/mnfr.202300271 [details]
- Zhang, L., Verwer, R. W. H., van Heerikhuize, J., Lucassen, P. J., Nathanielsz, P. W., Hol, E. M., Aronica, E., Dhillo, W. S., Meynen, G., & Swaab, D. F. (2024). Progesterone receptor distribution in the human hypothalamus and its association with suicide. Acta Neuropathologica Communications, 12, Article 16. https://doi.org/10.1186/s40478-024-01733-y [details]
2023
- Brosens, N., Lesuis, S. L., Bassie, I., Reyes, L., Gajadien, P., Lucassen, P. J., & Krugers, H. J. (2023). Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity. Learning & Memory, 30(7), 125-132. https://doi.org/10.1101/lm.053836.123 [details]
- Brosens, N., Samouil, D., Stolker, S., Katsika, E. V., Weggen, S., Lucassen, P. J., & Krugers, H. J. (2023). Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice. Journal of Alzheimer's Disease, 96(3), 1097-1113. https://doi.org/10.3233/JAD-230727 [details]
- Brosens, N., Simon, C., Kessels, H. W., Lucassen, P. J., & Krugers, H. J. (2023). Early life stress lastingly alters the function and AMPA-receptor composition of glutamatergic synapses in the hippocampus of male mice. Journal of Neuroendocrinology, 35(12), Article e13346. https://doi.org/10.1111/jne.13346 [details]
- Juncker, H. G., Naninck, E. F. G., van Keulen, B. J., Harinck, J. E., Schipper, L., Lucassen, P. J., van Goudoever, J. B., de Rooij, S. R., & Korosi, A. (2023). Maternal stress is associated with higher protein-bound amino acid concentrations in human milk. Frontiers in Nutrition, 10, Article 1165764. https://doi.org/10.3389/fnut.2023.1165764 [details]
- Loef, D., Tendolkar, I., van Eijndhoven, P. F. P., Hoozemans, J. J. M., Oudega, M. L., Rozemuller, A. J. M., Lucassen, P. J., Dols, A., & Dijkstra, A. A. (2023). Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients. Translational Psychiatry, 13, Article 355. https://doi.org/10.1038/s41398-023-02658-1 [details]
- Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. (2023). Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell Stem Cell, 30(2), 120-136. https://doi.org/10.1016/j.stem.2023.01.002 [details]
- Tosoni, G., Ayyildiz, D., Bryois, J., Macnair, W., Fitzsimons, C. P., Lucassen, P. J., & Salta, E. (2023). Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? Neuron, 111(11), 1714-1731. https://doi.org/10.1016/j.neuron.2023.03.010 [details]
2022
- Dohm-Hansen, S., Donoso, F., Lucassen, P. J., Clarke, G., & Nolan, Y. M. (2022). The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy? Neurobiology of Disease, 170, Article 105746. https://doi.org/10.1016/j.nbd.2022.105746 [details]
- Du Preez, A., Lefèvre-Arbogast, S., González-Domínguez, R., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust-Lima, C., Pallàs, M., Sánchez-Pla, A., Urpi-Sardà, M., Ruigrok, S. R., Altendorfer, B., Aigner, L., Lucassen, P. J., Korosi, A., Manach, C., ... Thuret, S. (2022). Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study. Molecular Psychiatry, 27(8), 3425–3440. https://doi.org/10.1038/s41380-022-01644-1 [details]
- Du Preez, A., Lefèvre-Arbogast, S., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust-Lima, C., Pallàs, M., Ruigrok, S. R., Altendorfer, B., González-Domínguez, R., Sánchez-Pla, A., Urpi-Sardà, M., Andres-Lacueva, C., Aigner, L., Lucassen, P. J., Korosi, A., ... Thuret, S. (2022). The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer's & Dementia, 18(4), 654-675. https://doi.org/10.1002/alz.12428 [details]
- Engelenburg, H. J., Lucassen, P. J., Sarafian, J. T., Parker, W., & Laman, J. D. (2022). Multiple sclerosis and the microbiota: Progress in understanding the contribution of the gut microbiome to disease. Evolution, medicine, and public health, 10(1), 277-294. https://doi.org/10.1093/emph/eoac009 [details]
- González-Domínguez, R., Castellano-Escuder, P., Lefèvre-Arbogast, S., Low, D. Y., Du Preez, A., Ruigrok, S. R., Lee, H., Helmer, C., Pallàs, M., Urpi-Sarda, M., Sánchez-Pla, A., Korosi, A., Lucassen, P. J., Aigner, L., Manach, C., Thuret, S., Samieri, C., & Andres-Lacueva, C. (2022). Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline. Alzheimer's Research & Therapy, 14(1), Article 1. https://doi.org/10.1186/s13195-021-00948-8 [details]
- Juncker, H. G., Naninck, E. F. G., Schipper, L., Lucassen, P. J., van Goudoever, J. B., de Rooij, S. R., & Korosi, A. (2022). Maternal stress in the postpartum period is associated with altered human milk fatty acid composition. Clinical nutrition, 41(11), 2517-2528. https://doi.org/10.1016/j.clnu.2022.09.013 [details]
- Kaiser, A., Reneman, L., Lucassen, P. J., de Vries, T. J., Schrantee, A., & Kaag, A. M. (2022). Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study. Brain imaging and behavior, 16(2), 680-691. https://doi.org/10.1007/s11682-021-00532-6 [details]
- Kaiser, A., Reneman, L., Solleveld, M. M., Coolen, B. F., Scherder, E. J. A., Knutsson, L., Bjørnerud, A., van Osch, M. J. P., Wijnen, J. P., Lucassen, P. J., & Schrantee, A. (2022). A Randomized Controlled Trial on the Effects of a 12-Week High- vs. Low-Intensity Exercise Intervention on Hippocampal Structure and Function in Healthy, Young Adults. Frontiers in Psychiatry, 12, Article 780095. https://doi.org/10.3389/fpsyt.2021.780095 [details]
- Merabet, N., Lucassen, P. J., Crielaard, L., Stronks, K., Quax, R., Sloot, P. M. A., la Fleur, S. E., & Nicolaou, M. (2022). How exposure to chronic stress contributes to the development of type 2 diabetes: a complexity science approach. Frontiers in Neuroendocrinology, 65, Article 100972. https://doi.org/10.1016/j.yfrne.2021.100972 [details]
- Neuffer, J., González-Domínguez, R., Lefèvre-Arbogast, S., Low, D. Y., Driollet, B., Helmer, C., Du Preez, A., de Lucia, C., Ruigrok, S. R., Altendorfer, B., Aigner, L., Lucassen, P. J., Korosi, A., Thuret, S., Manach, C., Pallàs, M., Urpi-Sardà, M., Sánchez-Pla, A., Andres-Lacueva, C., & Samieri, C. (2022). Exploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons. Nutrients, 14(21), Article 4688. https://doi.org/10.3390/nu14214688 [details]
- Reemst, K., Ruigrok, S. R., Bleker, L., Naninck, E. F. G., Ernst, T., Kotah, J. M., Lucassen, P. J., Roseboom, T. J., Pollux, B. J. A., de Rooij, S. R., & Korosi, A. (2022). Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: where are we at? Neuroscience and Biobehavioral Reviews, 138, Article 104627. https://doi.org/10.1016/j.neubiorev.2022.104627 [details]
- Sanguino-Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2022). An emerging role for microglia in stress-effects on memory. European Journal of Neuroscience, 55(9-10), 2491-2518. https://doi.org/10.1111/ejn.15188 [details]
- Zhang, L., Lucassen, P. J., Salta, E., Verhaert, P. D. E. M., & Swaab, D. F. (2022). Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough. Neuroscience and Biobehavioral Reviews, 132, 542-552. https://doi.org/10.1016/j.neubiorev.2021.12.023 [details]
2021
- Bielefeld, P., Abbink, M. R., Davidson, A. R., Reijner, N., Abiega, O., Lucassen, P. J., Korosi, A., & Fitzsimons, C. P. (2021). Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus. Stress - the International Journal on the Biology of Stress, 24(2), 189-195. https://doi.org/10.1080/10253890.2021.1879787 [details]
- González-Domínguez, R., Castellano-Escuder, P., Carmona, F., Lefèvre-Arbogast, S., Low, D. Y., Du Preez, A., Ruigrok, S. R., Manach, C., Urpi-Sarda, M., Korosi, A., Lucassen, P. J., Aigner, L., Pallàs, M., Thuret, S., Samieri, C., Sánchez-Pla, A., & Andres-Lacueva, C. (2021). Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study. Molecular nutrition & food research, 65(23), Article 2100606. https://doi.org/10.1002/mnfr.202100606 [details]
- Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A.-M., Gass, P., Grandjean, J., Havekes, R., ... Genzel, L. (2021). The continued need for animals to advance brain research. Neuron, 109(15), 2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015 [details]
- Koert, A., Ploeger, A., Bockting, C. L. H., Schmidt, M. V., Lucassen, P. J., Schrantee, A., & Mul, J. D. (2021). The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations. Neurobiology of Stress, 15, Article 100410. https://doi.org/10.1016/j.ynstr.2021.100410 [details]
- Kotah, J. M., Hoeijmakers, L., Nutma, E., Lucassen, P. J., & Korosi, A. (2021). Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice. Neurobiology of Stress, 15, Article 100379. https://doi.org/10.1016/j.ynstr.2021.100379 [details]
- Lefèvre-Arbogast, S., Hejblum, B. P., Helmer, C., Klose, C., Manach, C., Low, D. Y., Urpi-Sarda, M., Andres-Lacueva, C., González-Domínguez, R., Aigner, L., Altendorfer, B., Lucassen, P. J., Ruigrok, S. R., De Lucia, C., Du Preez, A., Proust-Lima, C., Thuret, S., Korosi, A., & Samieri, C. (2021). Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study. eBioMedicine, 64, Article 103216. https://doi.org/10.1016/j.ebiom.2021.103216 [details]
- Lesuis, S. L., Brosens, N., Immerzeel, N., van der Loo, R. J., Mitrić, M., Bielefeld, P., Fitzsimons, C. P., Lucassen, P. J., Kushner, S. A., van den Oever, M. C., & Krugers, H. J. (2021). Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry, 90(7), 494-504. https://doi.org/10.1016/j.biopsych.2021.04.010 [details]
- Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2021). Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience, 454, 151-161. https://doi.org/10.1016/j.neuroscience.2019.07.012 [details]
- Ruigrok, S. R., Abbink, M. R., Geertsema, J., Kuindersma, J. E., Stöberl, N., van der Beek, E. M., Lucassen, P. J., Schipper, L., & Korosi, A. (2021). Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers. Nutrients, 13(2), Article 288. https://doi.org/10.3390/nu13020288 [details]
- Ruigrok, S. R., Stöberl, N., Yam, K.-Y., de Lucia, C., Lucassen, P. J., Thuret, S., & Korosi, A. (2021). Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress. Frontiers in Neuroscience, 15, Article 695367. https://doi.org/10.3389/fnins.2021.695367 [details]
- Sharif, A., Fitzsimons, C. P., & Lucassen, P. J. (2021). Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. In D. F. Swaab, F. Kreier, P. J. Lucassen, A. Salehi, & R. M. Buijs (Eds.), The Human Hypothalamus: Anterior Region (pp. 125-140). (Handbook of Clinical Neurology; Vol. 179). Elsevier. https://doi.org/10.1016/B978-0-12-819975-6.00006-6 [details]
- Swaab, D. F., Buijs, R. M., Kreier, F., Lucassen, P. J., & Salehi, A. (2021). Introduction: The anterior hypothalamus. In D. F. Swaab, F. Kreier, P. J. Lucassen, A. Salehi, & R. M. Buijs (Eds.), The Human Hypothalamus: Anterior Region (pp. 3-5). (Handbook of Clinical Neurology; Vol. 179). Elsevier. https://doi.org/10.1016/B978-0-12-819975-6.00014-5 [details]
- Swaab, D. F., Buijs, R. M., Kreier, F., Lucassen, P. J., & Salehi, A. (2021). Introduction: The human hypothalamus and neuropsychiatric disorders. In D. F. Swaab, R. M. Buijs, F. Kreier, P. J. Lucassen, & A. Salehi (Eds.), The Human Hypothalamus: Neuropsychiatric Disorders (pp. 1-5). (Handbook of Clinical Neurology; Vol. 182). Elsevier. https://doi.org/10.1016/B978-0-12-819973-2.00001-0 [details]
- Swaab, D. F., Buijs, R. M., Lucassen, P. J., Salehi, A., & Kreier, F. (2021). Introduction: The human hypothalamus and neuroendocrine disorders. In D. F. Swaab, R. M. Buijs, P. J. Lucassen, A. Salehi, & F. Kreier (Eds.), The Human Hypothalamus: Neuroendocrine Disorders (pp. 1-5). (Handbook of Clinical Neurology; Vol. 181). Elsevier. https://doi.org/10.1016/B978-0-12-820683-6.00001-4 [details]
- Swaab, D. F., Kreier, F., Lucassen, P. J., Salehi, A., & Buijs, R. M. (2021). Introduction: The middle and posterior hypothalamus. Handbook of Clinical Neurology, 180, 1-4. https://doi.org/10.1016/B978-0-12-820107-7.00001-X [details]
- Zhang, L., Verwer, R. W. H., Zhao, J., Huitinga, I., Lucassen, P. J., & Swaab, D. F. (2021). Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features. Journal of Affective Disorders, 295, 893-903. https://doi.org/10.1016/j.jad.2021.08.098 [details]
- van der Wal, J., van Borkulo, C. D., Deserno, M. K., Breedvelt, J. J. F., Lees, M., Lokman, J. C., Borsboom, D., Denys, D., van Holst, R. J., Smidt, M. P., Stronks, K., Lucassen, P. J., van Weert, J. C. M., Sloot, P. M. A., Bockting, C. L., & Wiers, R. W. (2021). Advancing urban mental health research: from complexity science to actionable targets for intervention. The Lancet. Psychiatry, 8(11), 991-1000. https://doi.org/10.1016/S2215-0366(21)00047-X [details]
2020
- Abbink, M. R., Kotah, J. M., Hoeijmakers, L., Mak, A., Yvon-Durocher, G., van der Gaag, B., Lucassen, P. J., & Korosi, A. (2020). Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure. Journal of neuroinflammation, 17, Article 91. https://doi.org/10.1186/s12974-020-01762-z [details]
- Abbink, M. R., Schipper, L., Naninck, E. F. G., de Vos, C. M. H., Meier, R., van der Beek, E. M., Lucassen, P. J., & Korosi, A. (2020). The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes. Nutrients, 12(2), Article 570. https://doi.org/10.3390/nu12020570 [details]
- D'Alessio, L., Mesarosova, L., Anink, J. J., Kochen, S., Solís, P., Oddo, S., Konopka, H., Iyer, A. M., Mühlebner, A., Lucassen, P. J., Aronica, E., & van Vliet, E. A. (2020). Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug-resistant temporal lobe epilepsy and comorbid depression. Epilepsia, 61(8), 1595-1605. https://doi.org/10.1111/epi.16598 [details]
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research: correction. Current Biology, 30(21), 4328. https://doi.org/10.1016/j.cub.2020.10.033
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A.-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030 [details]
- Houghton, V., Du Preez, A., Lefèvre-Arbogast, S., de Lucia, C., Low, D. Y., Urpi-Sarda, M., Ruigrok, S. R., Altendorfer, B., González-Domínguez, R., Andres-Lacueva, C., Aigner, L., Lucassen, P. J., Korosi, A., Samieri, C., Manach, C., & Thuret, S. (2020). Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells. Frontiers in cell and developmental biology, 8, Article 806. https://doi.org/10.3389/fcell.2020.00806 [details]
- Hu, P., Liu, J., Maita, I., Kwok, C., Gu, E., Gergues, M. M., Kelada, F., Phan, M., Zhou, J.-N., Swaab, D. F., Pang, Z. P., Lucassen, P. J., Roepke, T. A., & Samuels, B. A. (2020). Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. The Journal of Neuroscience, 40(12), 2519-2537. https://doi.org/10.1523/JNEUROSCI.2410-19.2020 [details]
- Hu, P., Maita, I., Phan, M. L., Gu, E., Kwok, C., Dieterich, A., Gergues, M. M., Yohn, C. N., Wang, Y., Zhou, J.-N., Qi, X.-R., Swaab, D. F., Pang, Z. P., Lucassen, P. J., Roepke, T. A., & Samuels, B. A. (2020). Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis. Translational Psychiatry, 10, Article 396. https://doi.org/10.1038/s41398-020-01070-3 [details]
- Hu, P., van Dam, A.-M., Wang, Y., Lucassen, P. J., & Zhou, J.-N. (2020). Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms. Neuroscience and Biobehavioral Reviews, 112, 376-391. https://doi.org/10.1016/j.neubiorev.2020.02.013 [details]
- Krugers, H., Kessels, H., & Lucassen, P. (2020). Plasticiteit in de hersenen; synaptische plasticiteit en adulte neurogenese. In O. van den Heuvel, Y. van den Werf, B. Schmand, & B. Sabbe (Eds.), Leerboek neurowetenschappen voor de klinische psychiatrie (pp. 52-58). Boom. [details]
- Lesuis, S. L., Timmermans, W., Lucassen, P. J., Hoogenraad, C. C., & Krugers, H. J. (2020). Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. Journal of Neuroendocrinology, 32(1), Article e12811. https://doi.org/10.1111/jne.12811 [details]
- Lucassen, P. J., Fitzsimons, C. P., Salta, E., & Maletic-Savatic, M. (2020). Adult neurogenesis, human after all (again): Classic, optimized, and future approaches. Behavioural Brain Research, 381, Article 112458. https://doi.org/10.1016/j.bbr.2019.112458 [details]
- Schouten, M., Bielefeld, P., Garcia-Corzo, L., Passchier, E. M. J., Gradari, S., Jungenitz, T., Pons-Espinal, M., Gebara, E., Martín-Suárez, S., Lucassen, P. J., De Vries, H. E., Trejo, J. L., Schwarzacher, S. W., De Pietri Tonelli, D., Toni, N., Mira, H., Encinas, J. M., & Fitzsimons, C. P. (2020). Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. Molecular Psychiatry, 25(7), 1382-1405. https://doi.org/10.1038/s41380-019-0440-2 [details]
- Solleveld, M. M., Schrantee, A., Baek, H. K., Bottelier, M. A., Tamminga, H. G. H., Bouziane, C., Stoffelsen, R., Lucassen, P. J., Van Someren, E. J. W., Rijsman, R. M., & Reneman, L. (2020). Effects of 16 Weeks of Methylphenidate Treatment on Actigraph-Assessed Sleep Measures in Medication-Naive Children With ADHD. Frontiers in Psychiatry, 11, Article 82. https://doi.org/10.3389/fpsyt.2020.00082 [details]
- Solleveld, M. M., Schrantee, A., Homberg, J. R., Lucassen, P. J., & Reneman, L. (2020). The influence of age-of-onset of antidepressant use on the acute CBF response to a citalopram challenge; a pharmacological MRI study. Psychiatry Research. Neuroimaging, 303, Article 111126. https://doi.org/10.1016/j.pscychresns.2020.111126 [details]
- Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I., & Swaab, D. F. (2020). Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide. Journal of Psychiatric Research, 121, 31-38. https://doi.org/10.1016/j.jpsychires.2019.11.002 [details]
- Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I., & Swaab, D. F. (2020). Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features. Journal of Psychiatric Research, 125, 66-74. https://doi.org/10.1016/j.jpsychires.2020.03.003 [details]
2019
- Bielefeld, P., Durá, I., Danielewicz, J., Lucassen, P. J., Baekelandt, V., Abrous, D. N., Encinas, J. M., & Fitzsimons, C. P. (2019). Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behavioural Brain Research, 372, Article 112032. https://doi.org/10.1016/j.bbr.2019.112032 [details]
- Bielefeld, P., Schouten, M., Meijer, G. M., Breuk, M. J., Geijtenbeek, K., Karayel, S., Tiaglik, A., Vuuregge, A. H., Willems, R. A. L., Witkamp, D., Lucassen, P. J., Encinas, J. M., & Fitzsimons, C. P. (2019). Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures. Frontiers in Molecular Neuroscience, 12, Article 31. https://doi.org/10.3389/fnmol.2019.00031 [details]
- Gao, S., Zhang, T., Jin, L., Liang, D., Fan, G., Song, Y., Lucassen, P. J., Yu, R., & Swaab, D. F. (2019). CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. Cerebral Cortex, 29(9), 3752–3765. https://doi.org/10.1093/cercor/bhy254 [details]
- Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019). Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators. Frontiers in Behavioral Neuroscience, 13, Article 143. https://doi.org/10.3389/fnbeh.2019.00143 [details]
- Lesuis, S. L., Kaplick, P. M., Lucassen, P. J., & Krugers, H. J. (2019). Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology, 150, 175-183. https://doi.org/10.1016/j.neuropharm.2019.02.023 [details]
- Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2019). Early life stress impairs fear conditioning memory and synaptic plasticity; a potential role for GluN2B. Neuropharmacology, 149, 195-203. https://doi.org/10.1016/j.neuropharm.2019.01.010 [details]
- Low, D. Y., Lefèvre-Arbogast, S., González-Domínguez, R., Urpi-Sarda, M., Micheau, P., Petera, M., Centeno, D., Durand, S., Pujos-Guillot, E., Korosi, A., Lucassen, P. J., Aigner, L., Proust-Lima, C., Hejblum, B. P., Helmer, C., Andres-Lacueva, C., Thuret, S., Samieri, C., & Manach, C. (2019). Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort. Molecular nutrition & food research, 63(18), Article 1900177. https://doi.org/10.1002/mnfr.201900177 [details]
- Schrantee, A., Solleveld, M. M., Schwantje, H., Bruin, W. B., Mutsaerts, H.-J. M. M., Adriaanse, S. M., Lucassen, P., Booij, J., & Reneman, L. (2019). Dose-dependent effects of the selective serotonin reuptake inhibitor citalopram: A combined SPECT and phMRI study. Journal of Psychopharmacology, 33(6), 660-669. https://doi.org/10.1177/0269881119836229 [details]
- Yam, K.-Y., Schipper, L., Reemst, K., Ruigrok, S. R., Abbink, M. R., Hoeijmakers, L., Naninck, E. F. G., Zarekiani, P., Oosting, A., Van der Beek, E. M., Lucassen, P. J., & Korosi, A. (2019). Increasing availability of ω-3 fatty acid in the early-life diet prevents the early-life stress-induced cognitive impairments without affecting metabolic alterations. The FASEB Journal, 33(4), 5729–5740. https://doi.org/10.1096/fj.201802297R [details]
2018
- Hoeijmakers, L., Amelianchik, A., Verhaag, F., Kotah, J., Lucassen, P. J., & Korosi, A. (2018). Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice. Frontiers in Aging Neuroscience, 10, Article 61. https://doi.org/10.3389/fnagi.2018.00061 [details]
- Hoeijmakers, L., Lesuis, S. L., Krugers, H., Lucassen, P. J., & Korosi, A. (2018). A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress, 8, 172-185. https://doi.org/10.1016/j.ynstr.2018.02.003 [details]
- Hoeijmakers, L., Meerhoff, G. F., de Vries, J. W., Ruigrok, S. R., van Dam, A.-M., van Leuven, F., Korosi, A., & Lucassen, P. J. (2018). The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging, 61, 112-123. https://doi.org/10.1016/j.neurobiolaging.2017.09.013 [details]
- Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Gould, E., Hen, R., Abrous, D. N., Toni, N., Schinder, A. F., Zhao, X., Lucassen, P. J., & Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004 [details]
- Lesuis, S. L., Catsburg, L. A. E., Lucassen, P. J., & Krugers, H. J. (2018). Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm. Learning & Memory, 25(10), 544-549. https://doi.org/10.1101/lm.047811.118 [details]
- Lesuis, S. L., Hoeijmakers, L., Korosi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W., Lucassen, P. J., & Krugers, H. J. (2018). Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy, 10, Article 95. https://doi.org/10.1186/s13195-018-0422-7 [details]
- Lesuis, S. L., Weggen, S., Baches, S., Lucassen, P. J., & Krugers, H. J. (2018). Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry, 8, Article 53. https://doi.org/10.1038/s41398-018-0101-2 [details]
- Meerhoff, G. F., Vester, S. M., Hesseling, P., Klaassen, S. D., Cornelissen, A. S., Lucassen, P. J., & Joosen, M. J. A. (2018). Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology, 68, 167-176. https://doi.org/10.1016/j.neuro.2018.08.005 [details]
- Motta-Teixeira, L. C., Machado-Nils, A. V., Battagello, D. S., Diniz, G. B., Andrade-Silva, J., Silva Jr., S., Matos, R. A., do Amaral, F. G., Xavier, G. F., Bittencourt, J. C., Reiter, R. J., Lucassen, P. J., Korosi, A., & Cipolla-Neto, J. (2018). The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, 105, 146-156. https://doi.org/10.1016/j.yhbeh.2018.08.006 [details]
- Schrantee, A., Lucassen, P. J., Booij, J., & Reneman, L. (2018). Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity. European Neuropsychopharmacology, 28(10), 1173-1179. https://doi.org/10.1016/j.euroneuro.2018.07.099 [details]
- Zhao, J., Verwer, R. W. H., Gao, S.-F., Qi, X.-R., Lucassen, P. J., Kessels, H. W., & Swaab, D. F. (2018). Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide. Journal of Psychiatric Research, 102, 261-274. https://doi.org/10.1016/j.jpsychires.2018.04.020 [details]
- van Campen, J. S., Hessel, E. V. S., Bohmbach, K., Rizzi, G., Lucassen, P. J., Lakshmi Turimella, S., Umeoka, E. H. L., Meerhoff, G. F., Braun, K. P. J., de Graan, P. N. E., & Joëls, M. (2018). Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. Frontiers in Endocrinology, 9, Article 3. https://doi.org/10.3389/fendo.2018.00003 [details]
2017
- Abbink, M. R., Naninck, E. F. G., Lucassen, P. J., & Korosi, A. (2017). Early-life stress diminishes the increase in neurogenesis after exercise in adult female mice. Hippocampus, 27(8), 839-844. https://doi.org/10.1002/hipo.22745 [details]
- Bielefeld, P., Schouten, M., Lucassen, P. J., & Fitzsimons, C. P. (2017). Transcription factor oscillations in neural stem cells: implications for accurate control of gene expression. Neurogenesis, 4(1), Article e1262934. https://doi.org/10.1080/23262133.2016.1262934 [details]
- Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2017). Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, behavior, and immunity, 63, 160-175. https://doi.org/10.1016/j.bbi.2016.12.023 [details]
- Krugers, H. J., Arp, J. M., Xiong, H., Kanatsou, S., Lesuis, S. L., Korosi, A., Joels, M., & Lucassen, P. J. (2017). Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress, 6, 14-21. https://doi.org/10.1016/j.ynstr.2016.11.005 [details]
- Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017). Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory, 144, 27-35. https://doi.org/10.1016/j.nlm.2017.05.016 [details]
- Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017). Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience, 342, 101-119. https://doi.org/10.1016/j.neuroscience.2015.08.024 [details]
- Lucassen, P. J., Korosi, A., Krugers, H. J., & Oomen, C. A. (2017). Early life stress- and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Stress: Neuroendocrinology and Neurobiology Article 135–146 (Handbook of Stress; Vol. 2). Academic Press. https://doi.org/10.1016/B978-0-12-802175-0.00013-9 [details]
- Naninck, E. F. G., Oosterink, J. E., Yam, K.-Y., de Vries, L. P., Schierbeek, H., van Goudoever, J. B., Verkaik-Schakel, R. N., Plantinga, J. A., Plosch, T., Lucassen, P. J., & Korosi, A. (2017). Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 31(2), 505-518. https://doi.org/10.1096/fj.201600834R [details]
- Schrantee, A., Tremoleda, J. L., Wylezinska-Arridge, M., Bouet, V., Hesseling, P., Meerhoff, G. F., de Bruin, K. M., Koeleman, J., Freret, T., Boulouard, M., Desfosses, E., Galineau, L., Gozzi, A., Dauphin, F., Gsell, W., Booij, J., Lucassen, P. J., & Reneman, L. (2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS ONE, 12(2), Article e0172776. https://doi.org/10.1371/journal.pone.0172776 [details]
- Solleveld, M. M., Schrantee, A., Puts, N. A. J., Reneman, L., & Lucassen, P. J. (2017). Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. NeuroImage: Clinical, 15, 812-818. https://doi.org/10.1016/j.nicl.2017.06.003 [details]
- Walker, C.-D., Bath, K. G., Joels, M., Korosi, A., Larauche, M., Lucassen, P. J., Morris, M. J., Raineki, C., Roth, T. L., Sullivan, R. M., Taché, Y., & Baram, T. Z. (2017). Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress - the International Journal on the Biology of Stress, 20(5), 421-448. https://doi.org/10.1080/10253890.2017.1343296 [details]
- Yam, K. Y., Naninck, E. F. G., Abbink, M. R., la Fleur, S. E., Schipper, L., van den Beukel, J. C., Grefhorst, A., Oosting, A., van der Beek, E. M., Lucassen, P. J., & Korosi, A. (2017). Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology, 77, 186-195. https://doi.org/10.1016/j.psyneuen.2016.12.012 [details]
- Yam, K. Y., Ruigrok, S. R., Ziko, I., De Luca, S. N., Lucassen, P. J., Spencer, S. J., & Korosi, A. (2017). Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner. Psychoneuroendocrinology, 86, 73-77. https://doi.org/10.1016/j.psyneuen.2017.09.006 [details]
2016
- Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. (2016). Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis. Frontiers in Neuroendocrinology, 41, 44-58. https://doi.org/10.1016/j.yfrne.2016.05.001 [details]
- Herbert, J., & Lucassen, P. J. (2016). Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology, 41, 153-171. https://doi.org/10.1016/j.yfrne.2015.12.001 [details]
- Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016). Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics? Frontiers in Human Neuroscience, 10, Article 398. https://doi.org/10.3389/fnhum.2016.00398 [details]
- Hu, P., Wang, Y., Liu, J., Meng, F. T., Qi, X. R., Chen, L., van Dam, A. M., Joëls, M., Lucassen, P. J., & Zhou, J. N. (2016). Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus, 26(7), 911-923. https://doi.org/10.1002/hipo.22574 [details]
- Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016). Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment. Frontiers in Human Neuroscience, 10, Article 373. https://doi.org/10.3389/fnhum.2016.00373 [details]
- Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget, 7(26), 39118-39135. https://doi.org/10.18632/oncotarget.9776 [details]
- Lucassen, P. J., & Oomen, C. A. (2016). Stress, hippocampal neurogenesis and cognition: functional correlations. Frontiers in Biology, 11(3), 182-192. https://doi.org/10.1007/s11515-016-1412-4 [details]
- Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A-M., Czeh, B., & Korosi, A. (2016). Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Neurogenesis: a subject collection from Cold Spring Harbor Perspectives in Biology (pp. 255-270). (Cold Spring Harbor perspectives in biology). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a021303 [details]
- Lucassen, P. J., Oomen, C. A., Schouten, M., Encinas, J. M., & Fitzsimons, C. P. (2016). Adult Neurogenesis, Chronic Stress and Depression. In J. J. Canales (Ed.), Adult neurogenesis in the hippocampus: health, psychopathology, and brain disease (pp. 177-206). Academic Press. https://doi.org/10.1016/B978-0-12-801977-1.00008-8 [details]
- Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016). The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience, 10, Article 566. https://doi.org/10.3389/fnhum.2016.00566 [details]
- Schouten, M., Bielefeld, P., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Voskuyl, R. A., Lucassen, P. J., Jimenez, C. R., & Fitzsimons, C. P. (2016). Multi-omics profile of the mouse dentate gyrus after kainic acid induced status epilepticus. Scientific Data, 3, Article 160068. https://doi.org/10.1038/sdata.2016.68 [details]
- Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H.-JMM., Zwinderman, A. H., Groote, I. R., Rombouts, S. A. R. B., Lindauer, R. J. L., Klein, S., Niessen, W. J., Opmeer, B. C., Boer, F., Lucassen, P. J., Andersen, S. L., Geurts, H. M., & Reneman, L. (2016). Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clincal Trial. JAMA Psychiatry, 73(9), 955-962. https://doi.org/10.1001/jamapsychiatry.2016.1572 [details]
- Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X. R., Gao, S. F., Lucassen, P. J., & Swaab, D. F. (2016). Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research, 82, 8-15. https://doi.org/10.1016/j.jpsychires.2016.06.017 [details]
2015
- Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W., Huitinga, I., Lucassen, P. J., & van Dam, A. M. (2015). Brain region-specific gene expression profiles in freshly isolated rat microglia. Frontiers in Cellular Neuroscience, 9, 84. https://doi.org/10.3389/fncel.2015.00084 [details]
- Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., Krugers, H., & Joels, M. (2015). Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS ONE, 10(11), Article e0142012. https://doi.org/10.1371/journal.pone.0142012 [details]
- Lucassen, P. J., Jacobs, E. H., Hoeijmakers, L., Lesuis, S. L., Krugers, H., Korosi, A., Kuhn, H. G., & Boekhoorn, K. (2015). Stem cells and neurogenesis in relation to Alzheimer's disease Models. In H. G. Kuhn, & A. J. Eisch (Eds.), Neural Stem Cells in Development, Adulthood and Disease (pp. 53-78). (Stem Cell Biology and Regenerative Medicine series). Human Press. https://doi.org/10.1007/978-1-4939-1908-6_4 [details]
- Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015). Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology, 7(9), Article a021303. https://doi.org/10.1101/cshperspect.a021303 [details]
- Naninck, E. F. G., Hoeijmakers, L., Kakava-Georgiadou, N., Meesters, A., Lazic, S. E., Lucassen, P. J., & Korosi, A. (2015). Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus, 25(3), 309-325. https://doi.org/10.1002/hipo.22374 [details]
- Naninck, E. F. G., Lucassen, P. J., & Korosi, A. (2015). Consequences of early-life experiences on cognition and emotion: a role for nutrition and epigenetic mechanisms. In T. Canli (Ed.), The Oxford handbook of molecular psychology (pp. 311-336). Oxford University Press. https://doi.org/10.1093/oxfordhb/9780199753888.013.003 [details]
- Oosterink, J. E., Naninck, E. F. G., Korosi, A., Lucassen, P. J., van Goudoever, J. B., & Schierbeek, H. (2015). Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis. Journal of Chromatography B, 998-999, 106-113. https://doi.org/10.1016/j.jchromb.2015.07.008 [details]
- Schouten, M., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Bielefeld, P., Voskuyl, R. A., Lucassen, P. J., Jimenez, C. R., & Fitzsimons, C. P. (2015). MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Scientific Reports, 5, Article 12448. https://doi.org/10.1038/srep12448 [details]
- Schrantee, A., Václavů, L., Heijtel, D. F. R., Caan, M. W. A., Gsell, W., Lucassen, P. J., Nederveen, A. J., Booij, J., & Reneman, L. (2015). Dopaminergic System Dysfunction in Recreational Dexamphetamine Users. Neuropsychopharmacology, 40, 1172-1180. https://doi.org/10.1038/npp.2014.301 [details]
- Yam, K. Y., Naninck, E. F. G., Schmidt, M. V., Lucassen, P. J., & Korosi, A. (2015). Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms. Stress - the International Journal on the Biology of Stress, 18(3), 328-342. https://doi.org/10.3109/10253890.2015.1064890 [details]
- van der Marel, K., Bouet, V., Meerhoff, G. F., Freret, T., Boulouard, M., Dauphin, F., Klomp, A., Lucassen, P. J., Homberg, J. R., Dijkhuizen, R. M., & Reneman, L. (2015). Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis. Neuroscience, 309, 243-258. https://doi.org/10.1016/j.neuroscience.2015.04.044 [details]
2014
- Bielefeld, P., van Vliet, E. A., Gorter, J. A., Lucassen, P. J., & Fitzsimons, C. P. (2014). Different subsets of newborn granule cells: a possible role in epileptogenesis? European Journal of Neuroscience, 39(1), 1-11. https://doi.org/10.1111/ejn.12387 [details]
- Boekhoorn, K., van Dis, V., Goedknegt, E., Sobel, A., Lucassen, P. J., & Hoogenraad, C. C. (2014). The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology, 74(12), 1226-1242. https://doi.org/10.1002/dneu.22200 [details]
- Doorn, K. J., Drukarch, B., van Dam, A.-M., & Lucassen, P. J. (2014). Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity, 2014, 959154. https://doi.org/10.1155/2014/959154 [details]
- Doorn, K. J., Goudriaan, A., Blits-Huizinga, C., Bol, J. G. J. M., Rozemuller, A. J., Hoogland, P. V. J. M., Lucassen, P. J., Drukarch, B., van de Berg, W. D. J., & van Dam, A-M. (2014). Increased Amoeboid Microglial Density in the Olfactory Bulb of Parkinson's and Alzheimer's Patients. Brain Pathology, 24(2), 152-165. Advance online publication. https://doi.org/10.1111/bpa.12088 [details]
- Doorn, K. J., Moors, T., Drukarch, B., van de Berg, W. D. J., Lucassen, P. J., & van Dam, A.-M. (2014). Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathologica Communications, 2, 90. https://doi.org/10.1186/s40478-014-0090-1 [details]
- Fitzsimons, C. P., van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., van den Hurk, M., Boks, M. P., Biojone, C., Joca, S., Steinbusch, H. W., Lunnon, K., Mastroeni, D. F., Mill, J., Lucassen, P. J., Coleman, P. D., Van den Hove, D. L., & Rutten, B. P. F. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration, 9, 25. https://doi.org/10.1186/1750-1326-9-25 [details]
- Hoeijmakers, L., Harbich, D., Schmid, B., Lucassen, P. J., Wagner, K. V., Schmidt, M. V., & Hartmann, J. (2014). Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS ONE, 9(4), e95796. https://doi.org/10.1371/journal.pone.0095796 [details]
- Hoeijmakers, L., Lucassen, P. J., & Korosi, A. (2014). The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience, 7, 103. https://doi.org/10.3389/fnmol.2014.00103 [details]
- Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014). Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PLoS ONE, 9(5), Article e97603. https://doi.org/10.1371/journal.pone.0097603 [details]
- Loi, M., Koricka, S., Lucassen, P. J., & Joëls, M. (2014). Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology, 5, Article 13. https://doi.org/10.3389/fendo.2014.00013 [details]
- Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F. X., van Dam, A. M., Rajkowska, G., Swaab, D. F., & Czéh, B. (2014). Neuropathology of stress. Acta Neuropathologica, 127(1), 109-135. https://doi.org/10.1007/s00401-013-1223-5 [details]
- Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014). Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity, 2014, 693851. https://doi.org/10.1155/2014/693851 [details]
- Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. https://doi.org/10.1007/s00429-013-0589-4 [details]
- van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., Dijkhuizen, R. M., & Reneman, L. (2014). Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function. Neuropsychopharmacology, 39(2), 263-273. Advance online publication. https://doi.org/10.1038/npp.2013.169 [details]
2013
- Fitzsimons, C. P., van Hooijdonk, L. W. A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T. G., Saaltink, D. J., Dijkmans, T., Steindler, D. A., Verhaagen, J., Verbeek, F. J., Lucassen, P. J., de Kloet, E. R., Meijer, O. C., Karst, H., Joels, M., Oitzl, M. S., & Vreugdenhil, E. (2013). Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry, 18(9), 993-1005. Advance online publication. https://doi.org/10.1038/mp.2012.123 [details]
- Hu, P., Liu, J., Zhao, Q., Qi, X. R., Qi, C. C., Lucassen, P. J., & Zhou, J. N. (2013). All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation. Translational Psychiatry, 3, e336. https://doi.org/10.1038/tp.2013.98 [details]
- Lucassen, P. J., Fitzsimons, C. P., Korosi, A., Joels, M., Belzung, C., & Abrous, D. N. (2013). Stressing new neurons into depression? Molecular Psychiatry, 18(4), 396-397. https://doi.org/10.1038/mp.2012.39 [details]
- Lucassen, P. J., Naninck, E. F. G., van Goudoever, J. B., Fitzsimons, C., Joels, M., & Korosi, A. (2013). Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends in Neurosciences, 36(11), 621-631. https://doi.org/10.1016/j.tins.2013.08.002 [details]
- Marlatt, M. W., Potter, M. C., Bayer, T. A., van Praag, H., & Lucassen, P. J. (2013). Prolonged Running, not Fluoxetine Treatment, Increases Neurogenesis, but does not Alter Neuropathology, in the 3xTg Mouse Model of Alzheimer's Disease. Current Topics in Behavioral Neurosciences, 15, 313-340. https://doi.org/10.1007/7854_2012_237 [details]
- Qi, X. R., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J. N., & Swaab, D. F. (2013). Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients. Psychoneuroendocrinology, 38(6), 863-870. https://doi.org/10.1016/j.psyneuen.2012.09.014 [details]
- Wang, Q., van Heerikhuize, J., Aronica, E., Kawata, M., Seress, L., Joels, M., Swaab, D. F., & Lucassen, P. J. (2013). Glucocorticoid receptor protein expression in human hippocampus; stability with age. Neurobiology of Aging, 34(6), 1662-1673. https://doi.org/10.1016/j.neurobiolaging.2012.11.019 [details]
- Zalachoras, I., Houtman, R., Atucha, E., Devos, R., Tijssen, A. M. I., Hu, P., Lockey, P. M., Datson, N. A., Belanoff, J. K., Lucassen, P. J., Joëls, M., de Kloet, E. R., Roozendaal, B., Hunt, H., & Meijer, O. C. (2013). Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator. Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7910-7915. https://doi.org/10.1073/pnas.1219411110 [details]
2012
- Claessens, S. E. F., Belanoff, J. K., Kanatsou, S., Lucassen, P. J., Champagne, D. L., & de Kloet, E. R. (2012). Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy. Brain Research, 1482, 1-12. https://doi.org/10.1016/j.brainres.2012.08.017 [details]
- Datson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O., Goeman, J., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2012). The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus, 22(2), 359-371. Advance online publication. https://doi.org/10.1002/hipo.20905 [details]
- Doorn, K. J., Lucassen, P. J., Boddeke, H. W., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. M. (2012). Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease. Progress in Neurobiology, 98(2), 222-238. Advance online publication. https://doi.org/10.1016/j.pneurobio.2012.06.005 [details]
- Fitzsimons, C. P., Vreugdenhil, E., & Lucassen, P. J. (2012). Inhibition of Adult Neurogenesis through ERK5 knockdown Impairs Complex Hippocampus-dependent Spatial Memory Tasks. Future Neurology, 7(5), 531-535. https://doi.org/10.2217/fnl.12.55 [details]
- Hu, P., Oomen, C., van Dam, A. M., Wester, J., Zhou, J. N., Joëls, M., & Lucassen, P. J. (2012). A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. PLoS ONE, 7(9), Article e46224. https://doi.org/10.1371/journal.pone.0046224 [details]
- Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. Advance online publication. https://doi.org/10.1016/j.bbr.2011.07.037 [details]
- Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. https://doi.org/10.1016/j.neuropharm.2011.09.022 [details]
- Lucassen, P. J. (2012). Chemotherapy modulates specific aspects of cognition parallel to neurogenesis (Commentary on Nokia et al.). European Journal of Neuroscience, 36, 3519-3520. https://doi.org/10.1111/ejn.12056 [details]
- Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis and BDNF levels in female C57Bl/6J mice. Developmental Neurobiology, 72(6), 943-952. https://doi.org/10.1002/dneu.22009 [details]
- Saaltink, D. J., Håvik, B., Verissimo, C., Lucassen, P. J., & Vreugdenhil, E. (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The journal of comparative neurology, 520(13), 2805-2823. https://doi.org/10.1002/cne.23144 [details]
- Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012). New neurons in aging brains: molecular control by small non-coding RNAs. Frontiers in Neuroscience, 6, Article 25. https://doi.org/10.3389/2Ffnins.2012.00025 [details]
- Wang, Q., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2012). Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology, 62(1), 527-533. https://doi.org/10.1016/j.neuropharm.2011.09.014 [details]
2011
- Bruel-Jungerman, E., Lucassen, P. J., & Francis, F. (2011). Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research, 221(2), 379-388. https://doi.org/10.1016/j.bbr.2011.01.021 [details]
- Eendebak, R. J. A. H., Lucassen, P. J., & Fitzsimons, C. P. (2011). Nuclear receptors and microRNAs: who regulates the regulators in neural stem cells? FEBS Letters, 585(5), 717-22. https://doi.org/10.1016/j.febslet.2011.01.039 [details]
- Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011). Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure and Function, 216(3), 227-237. https://doi.org/10.1007/s00429-011-0305-1 [details]
- Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., Joëls, M., & de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis (pp. 103-120). Wiley-VCH. https://doi.org/10.1002/9783527633968.ch6 [details]
- Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. https://doi.org/10.1016/j.expneurol.2011.05.008 [details]
- Naninck, E. F. G., Lucassen, P. J., & Bakker, J. (2011). Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology, 23(5), 383-392. https://doi.org/10.1111/j.1365-2826.2011.02125.x [details]
- Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011). Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience, 190, 145-155. https://doi.org/10.1016/j.neuroscience.2011.06.027 [details]
- Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. https://doi.org/10.1007/s00213-010-1922-8 [details]
- Van Bokhoven, P., Oomen, C. A., Hoogendijk, W. J., Smit, A. B., Lucassen, P. J., & Spijker, S. (2011). Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. European Journal of Neuroscience, 33(10), 1833-1840. https://doi.org/10.1111/j.1460-9568.2011.07668.x [details]
- Xiao, A. W., He, J., Wang, Q., Luo, Y., Sun, Y., Zhou, Y. P., Guan, Y., Lucassen, P. J., & Dai, J. P. (2011). The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin, 27(5), 287-99. https://doi.org/10.1007/s12264-011-1736-7 [details]
- van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M., & Lucassen, P. J. (2011). Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Progress in Neurobiology, 93(2), 149-164. https://doi.org/10.1016/j.pneurobio.2010.10.008 [details]
2010
- Christensen, D. Z., Schneider-Axmann, T., Lucassen, P. J., Bayer, T. A., & Wirths, O. (2010). Accumulation of intraneuronal Aβ correlates with ApoE4 genotype. Acta Neuropathologica, 119(5), 555-566. https://doi.org/10.1007/s00401-010-0666-1 [details]
- Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. https://doi.org/10.3389/fnsyn.2010.00024 [details]
- Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010). Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology, 20(1), 1-17. https://doi.org/10.1016/j.euroneuro.2009.08.003 [details]
- Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010). Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology, 58(6), 940-949. https://doi.org/10.1016/j.neuropharm.2010.01.012 [details]
- Marlatt, M. W., & Lucassen, P. J. (2010). Neurogenesis and Alzheimer's disease: biology and pathophysiology in mice and men. Current Alzheimer Research, 7(2), 113-125. https://doi.org/10.2174/156720510790691362 [details]
- Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010). Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research, 1341, 93-99. https://doi.org/10.1016/j.brainres.2010.03.086 [details]
- Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., Joëls, M., Lucassen, P. J., & Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. https://doi.org/10.1523/JNEUROSCI.0247-10.2010 [details]
- Wirths, O., Bethge, T., Marcello, A., Harmeier, A., Jawhar, S., Lucassen, P. J., Multhaup, G., Brody, D. L., Esparza, T., Ingelsson, M., Kalimo, H., Lannfelt, L., & Bayer, T. A. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases. Journal of Neural Transmission, 117(1), 85-96. https://doi.org/10.1007/s00702-009-0314-x [details]
2009
- Bao, A. M., Lucassen, P. J., & Swaab, D. F. (2009). Neuroendocrinology of psychiatric disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2641-2645). Springer. [details]
- Boekhoorn, K., & Lucassen, P. J. (2009). Nieuwe neuronen in volwassen hersenen. Tijdschrift voor Neuropsychiatrie & Gedragsneurologie, (juni), 119-123. [details]
- Boer, K., Lucassen, P. J., Spliet, W. G. M., Vreugdenhil, E., van Rijen, P. C., Troost, D., Jansen, F. E., & Aronica, E. (2009). Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia, 50(12), 2629-2637. https://doi.org/10.1111/j.1528-1167.2009.02191.x [details]
- Joosen, M. J. A., Jousma, E., van den Boom, T. M., Kuijpers, W. C., Smit, A. B., Lucassen, P. J., & van Helden, H. P. M. (2009). Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 30(1), 72-80. https://doi.org/10.1016/j.neuro.2008.11.010 [details]
- Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. https://doi.org/10.1016/j.brainres.2009.03.036 [details]
- Lucassen, P. J., & Swaab, D. F. (2009). Endocrine disorders of development and growth. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1103-1106). Springer. [details]
- Lucassen, P. J., & Swaab, D. F. (2009). Hypothalamo-pituitary-adrenal axis, stress and depression. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1892-1895). Springer. [details]
- Lucassen, P. J., Boekhoorn, K., & Francis, F. (2009). Cortical development - Disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 894-896). Springer. [details]
- Lucassen, P. J., Bosch, O. J., Jousma, E., Krömer, S. A., Andrew, R., Seckl, J. R., & Neumann, I. D. (2009). Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. European Journal of Neuroscience, 29(1), 97-103. https://doi.org/10.1111/j.1460-9568.2008.06543.x [details]
- Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Czeh, B., & Oomen, C. A. (2009). Do depression, stress, sleep disruption, and inflammation alter hippocampal apoptosis and neurogenesis? In C. M. Pariante (Ed.), Understanding depression: A translational approach (pp. 139-156). Oxford University Press. [details]
- Lucassen, P. J., Scheper, W., & van Someren, E. J. W. (2009). Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews, 13(3), 183-186. https://doi.org/10.1016/j.smrv.2008.12.004 [details]
- Marlatt, M. W., Hoozemans, J. J. M., Veerhuis, R., & Lucassen, P. J. (2009). Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? US Neurology, 5(1), 12-14. http://www.touchneurology.com/articles/alzheimer-s-disease-and-adult-neurogenesis-are-endogenous-stem-cells-part-solution [details]
- Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS ONE, 4(1), Article e3675. https://doi.org/10.1371/journal.pone.0003675 [details]
- Swaab, D. F., & Lucassen, P. J. (2009). Drinking disorders and osmoregulation. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1010-1014). Springer. [details]
- Swaab, D. F., & Lucassen, P. J. (2009). Hypothalamo-neurohypophysial system. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 1888-1892). Springer. [details]
- Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of eating disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2635-2637). Springer. [details]
- Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of tumors. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2645-2648). Springer. [details]
- Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 2631-2635). Springer. [details]
2008
- Boekhoorn, K., Sarabdjitsingh, A., Kommerie, H., de Punder, K., Schouten, T., Lucassen, P. J., & Vreugdenhil, E. (2008). Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. The journal of comparative neurology, 507(4), 1639-1652. https://doi.org/10.1002/cne.21646 [details]
- Lucassen, P. J., Oomen, C., van Dam, A-M., & Czéh, B. (2008). Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Adult neurogenesis (pp. 363-396). (Cold Spring Harbor monograph series; Vol. 52). Cold Spring Harbor Laboratory Press. [details]
- Marlatt, M. W., Lucassen, P. J., Perry, G., Smith, M. A., & Zhu, X. (2008). Alzheimer's disease: Cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease, 15(2), 199-210. http://iospress.metapress.com/content/d38w8828365q43vx/ [details]
- Simic, G., Mladinov, M., Seso Simic, D., Jovanov Milosevic, N., Islam, A., Pajtak, A., Barisic, N., Sertic, J., Lucassen, P. J., Hof, P. R., & Kruslin, B. (2008). Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathologica, 115(3), 313-326. https://doi.org/10.1007/s00401-007-0327-1 [details]
- Thompson, A., Boekhoorn, K., van Dam, A-M., & Lucassen, P. J. (2008). Changes in adult neurogenesis in neurodegenerative diseases: Cause or consequence? Genes Brain and Behavior, 7(s1), 28-42. https://doi.org/10.1111/j.1601-183X.2007.00379.x [details]
2007
- Czeh, B., & Lucassen, P. J. (2007). What causes the hippocampal volume decrease in depression? : Are neurogenesis, glial changes and apoptosis implicated? European archives of psychiatry and clinical neuroscience, 257, 250-260. https://doi.org/10.1007/s00406-007-0728-0 [details]
- Joëls, M., Karst, H., Krugers, H., & Lucassen, P. J. (2007). Chronic stress: Implications for neuronal morphology, function and neurogenesis. Frontiers in Neuroendocrinology, 28(2), 72-96. https://doi.org/10.1016/j.yfrne.2007.04.001 [details]
- Krugers, H., van der Linden, S., van Olst, E., Alfarez, D. N., Maslam, S., Lucassen, P. J., & Joëls, M. (2007). Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse, 61(4), 221-230. https://doi.org/10.1002/syn.20359 [details]
- Kuhn, H. G., Cooper-Kuhn, C. M., Boekhoorn, K., & Lucassen, P. J. (2007). Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant? European archives of psychiatry and clinical neuroscience, 257(5), 281-289. https://doi.org/10.1007/s00406-007-0732-4 [details]
- Oomen, C. A., Mayer, J. L., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2007). Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. European Journal of Neuroscience, 26, 3395-3401. https://doi.org/10.1111/j.1460-9568.2007.05972.x [details]
- Sennvik, K., Boekhoorn, K., Lasrado, R., Terwel, D., Verhaeghe, S., Korr, H., Schmitz, C., Tomiyama, T., Mori, H., Krugers, H., Joels, M., Ramakers, G. J. A., Lucassen, P. J., & van Leuven, F. (2007). Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. The FASEB Journal, 21(9), 2149-2161. https://doi.org/10.1096/fj.06-7735com [details]
- Veenema, A. H., de Kloet, E. R., de Wilde, M. C., Roelofs, A. J., Kawata, M., Buwalda, B., Neumann, I. D., Koolhaas, J. M., & Lucassen, P. J. (2007). Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice. Journal of Neuroendocrinology, 19(7), 489-498. https://doi.org/10.1111/j.1365-2826.2007.01555.x [details]
- Verwer, R. W. H., Sluiter, A. A., Balesar, R. A., Baayen, J. C., Noske, D. P., Dirven, C. M., Wouda, J., van Dam, A. M., Lucassen, P. J., & Swaab, D. F. (2007). Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain, 130, 3321-3335. https://doi.org/10.1093/brain/awm264 [details]
- Vreugdenhil, E., Kolk, S. M., Boekhoorn, K., Fitzsimons, C. P., Schaaf, M., Schouten, T., Sarabdjitsingh, A., Sibug, R., & Lucassen, P. J. (2007). Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. European Journal of Neuroscience, 25(3), 635-648. https://doi.org/10.1111/j.1460-9568.2007.05318.x [details]
2006
- Boekhoorn, K., Joëls, M., & Lucassen, P. J. (2006). Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease, 24, 1-14. https://doi.org/10.1016/j.nbd.2006.04.017 [details]
- Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, G. J. A., de Vos, K., Krugers, H., Tomiyama, T., Mori, H., Joels, M., van Leuven, F., & Lucassen, P. J. (2006). Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of Neuroscience, 26(13), 3514-3523. https://doi.org/10.1523/JNEUROSCI.5425-05.2006 [details]
- Lucassen, P. J., Heine, V. M., van der Beek, E., Wiegant, V., de Kloet, E. R., Joëls, M., Fuchs, E., Swaab, D. F., & Czeh, B. (2006). Stress, Depression and Hippocampal Apoptosis. CNS & neurological disorders drug targets, 5(5), 531-546. [details]
- Mayer, J., Klumpers, L., Maslam, S., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2006). Brief treatment with the glucocorticoid receptor antagonist mifeprestone normalizes the corticosterone-induced reduction of adult hippocampal neurogenesis. Journal of Neuroendocrinology, 18, 1-3. https://doi.org/10.1111/j.1365-2826.2005.01361.x [details]
- Rodriquez-Contrera, A., de Lange, R. P. J., Lucassen, P. J., & Borst, J. G. G. (2006). Branching of calyceal afferents during postnatal development in the rat auditory brainstem. The journal of comparative neurology, 496, 214-228. https://doi.org/10.1002/cne.20918 [details]
2005
- Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005). Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression. European Journal of Neuroscience, 21, 1304-1314. https://doi.org/10.1111/j.1460-9568.2005.03951.x [details]
- Lucassen, P. J. (2005). "Nuclei of the Human Hypothalamus", and "Neuropathology of the Human Hypothalamus and Adjacent Structures". Journal of Neuropathology and Experimental Neurology, 64(3), 260-261. [details]
- Swaab, D. F., Bao, A. M., & Lucassen, P. J. (2005). The stress system in the human brain in depression and neurodegeneration. Ageing research reviews, 4, 141-194. https://doi.org/10.1016/j.arr.2005.03.003 [details]
2004
- Fuchs, E., Czeh, B., Kole, M., Michaelis, T., & Lucassen, P. J. (2004). Alterations of neuroplasticity in depression: the hippocampus and beyond. European Neuropsychopharmacology, 14, 481-490. [details]
- Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004). Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G(1) arrest involvement. Neuroscience, 129, 593-601. https://doi.org/10.1016/j.neuroscience.2004.07.048 [details]
- Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004). Prominent decline of newborn of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in the absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiology of Aging, 25(3), 361-375. Advance online publication. https://doi.org/10.1016/S0197-4580(03)00090-3 [details]
- Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004). Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. European Journal of Neuroscience, 19(1), 131-144. https://doi.org/10.1046/j.1460-9568.2003.03100.x [details]
- Joëls, M., Karst, H., Alfarez, D. N., Heine, V. M., Qin, Y. J., van Riel, E., Verkuyl, M., Lucassen, P. J., & Krugers, H. (2004). Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress - the International Journal on the Biology of Stress, 7(4), 221-331. https://doi.org/10.1080/10253890500070005 [details]
- Lucassen, P. J., Fuchs, E., & Czeh, B. (2004). Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biological Psychiatry, 15, 789-796. [details]
- Nair, S. M., Karst, H., Dumas, T., Philips, R., Sapolsky, R. M., Rumpff-van Essen, L., Maslam, S., Lucassen, P. J., & Joëls, M. (2004). Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation. European Journal of Neuroscience, 20(12), 3233-3243. https://doi.org/10.1111/j.1460-9568.2004.03819.x [details]
- van der Beek, E. M., Wiegant, V. M., Schouten, W. G., van Eerdenburg, F. J. C. M., Loijens, L. W. S., van der Plas, C., Benning, M. A., de Vries, H., de Kloet, E. R., & Lucassen, P. J. (2004). Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels. Hippocampus, 14(6), 688-700. https://doi.org/10.1002/hipo.10213 [details]
2003
- Gorter, J. A., Goncalves Pereira, P. M., van Vliet, E. A., Aronica, E. M. A., Lopes da Silva, F. H., & Lucassen, P. J. (2003). Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia, 44, 647-658. https://doi.org/10.1046/j.1528-1157.2003.53902.x [details]
- Qin, Y. J., Heine, V. M., Karst, H., Lucassen, P. J., & Joëls, M. (2003). Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue. Journal of Neuroscience Methods, 131, 205-211. https://doi.org/10.1016/j.jneumeth.2003.08.010 [details]
- Rijk de, R. H., Schaaf, M., Stam, F. J., de Jong, I. M. E., Swaab, D. F., Ravid, R., Vreugdenhil, E., Cidlowski, J. A., de Kloet, E. R., & Lucassen, P. J. (2003). Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. Molecular Brain Research, 116, 17-26. https://doi.org/10.1016/S0169-328X(03)00209-2 [details]
2002
- Grootendorst, J., Kempes, M. M., Lucassen, P. J., Dalm, S., de Kloet, E. R., & Oitzl, M. S. (2002). Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice. Brain Research, 953, 281-285. https://doi.org/10.1016/S0006-8993(02)03399-1 [details]
- Lucassen, P. J., Heine, V. M., Boekhoorn, K., & Krugers, H. (2002). Neural Degeneration. In L. Nadel (Ed.), Encyclopedia of Cognitive Science (pp. 246-252). Nature Publishing Group. [details]
2001
- Fuchs, E., Flugge, G., Ohl, F., Lucassen, P. J., Vollmann-Honsdorf, G. K., & Michaelis, T. (2001). Psychosocial stress, glucocorticoids and structural alterations in the tree shrew hippocampus. Physiology & behavior, 73(3), 285-291. https://doi.org/10.1016/S0031-9384(01)00497-8 [details]
- Karssen, A. M., Meijer, O. C., van der Sant, I. C., Lucassen, P. J., de Lange, E. C. M., de Boer, A. G. E. M., & de Kloet, E. R. (2001). Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology, 142(6), 2686-2686. https://doi.org/10.1210/en.142.6.2686 [details]
- Lucassen, P. J., & de Kloet, E. R. (2001). Glucocorticoids and the aging brain; cause or consequence? In P. Hof, & C. Mobbs (Eds.), Functional Neurobiology of Aging (pp. 883-905). Academic Press. [details]
- Lucassen, P. J., Muller, M. B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., Hoogendijk, W. J. G., de Kloet, E. R., & Swaab, D. F. (2001). Hippocampal apoptosis in major depression in a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology, 158(2), 453-468. https://doi.org/10.1016/S0002-9440(10)63988-0 [details]
- Lucassen, P. J., Vollmann-Honsdorf, G. K., Gleisberg, M., Czeh, B., de Kloet, E. R., & Fuchs, E. (2001). Chronic psichosocial stress differentially affects in hippocampal subregions and cortex of the adult tree shrew. European Journal of Neuroscience, 14(1), 161-166. https://doi.org/10.1046/j.0953-816x.2001.01629.x [details]
- Müller, M. B., Lucassen, P. J., Yassouridis, A., Hoogendijk, W. J. G., Holsboer, F., & Swaab, D. F. (2001). Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. European Journal of Neuroscience, 14, 1603-1612. https://doi.org/10.1046/j.0953-816x.2001.01784.x [details]
2000
- Simic, G., Lucassen, P. J., Krsnik, Z., Kruslin, B., Kostovic, I., Winblad, B., & Bogdanovi, N. (2000). NOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Experimental Neurology, 165, 12-26. https://doi.org/10.1006/exnr.2000.7448 [details]
- Simic, G., Seso-Simic, D., Lucassen, P. J., Islam, A., Krsnik, Z., Cviko, A., Jelasic, D., Barisic, N., Winblad, B., Kostovic, I., & Kruslin, B. (2000). Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease. Journal of Neuropathology and Experimental Neurology, 59, 398-407. https://doi.org/10.1093/jnen/59.5.398 [details]
1997
- Lucassen, P. J., van Heerikhuize, J. J., Guldenaar, S. E. F., Pool, C. W., Hofman, M. A., & Swaab, D. F. (1997). Unchanged amounts of vasopressin mRNA in the supraoptic and paraventricular nucleus during aging and in Alzheimer's disease. Journal of Neuroendocrinology, 9, 297-305. https://doi.org/10.1046/j.1365-2826.1997.t01-1-00583.x [details]
2025
- Wiers, R. W., Urban Mental Health Researchers, El Marroun, H., Bockting, C., & Krugers, H. (2025). Debate: Urban versus rural environments – which is better for mental health? The one good thing about a small town…. Child and Adolescent Mental Health, 30(2), 189-191. https://doi.org/10.1111/camh.12771 [details]
2022
- Zhang, L., Verwer, R. W. H., van Heerikhuize, J., Balesar, R., Correa-da-Silva, F., Slabe, Z., Lucassen, P. J., & Swaab, D. F. (2022). Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit. BioRxiv. https://doi.org/10.1101/2022.11.22.516142
2021
- Swaab, D. F., Buijs, R. M., Kreier, F., Lucassen, P. J., & Salehi, A. (2021). Preface. In D. F. Swaab, R. M. Buijs, F. Kreier, P. J. Lucassen, & A. Salehi (Eds.), The Human Hypothalamus: Neuropsychiatric Disorders (pp. ix-xi). (Handbook of Clinical Neurology; Vol. 182). Elsevier. https://doi.org/10.1016/B978-0-12-819973-2.09997-4 [details]
- Swaab, D. F., Kreier, F., Lucassen, P. J., Salehi, A., & Buijs, R. M. (2021). Preface. In D. F. Swaab, F. Kreier, P. J. Lucassen, A. Salehi, & R. M. Buijs (Eds.), The Human Hypothalamus: Anterior Region (pp. ix-xi). (Handbook of Clinical Neurology; Vol. 179). Elsevier. https://doi.org/10.1016/B978-0-12-819975-6.09987-8 [details]
2020
- Lucassen, P. J., Toni, N., Kempermann, G., Frisen, J., Gage, F. H., & Swaab, D. F. (2020). Limits to human neurogenesis-really? Molecular Psychiatry, 25(10), 2207-2209. https://doi.org/10.1038/s41380-018-0337-5 [details]
2019
- Lucassen, P. J., Lesuis, S. L., Hoeijmakers, L., Yam, K. Y., Fitzsimons, C. P., Korosi, A., & Krugers, H. (2019). Brain plasticity in relation to (early life) stress, nutrition and dementia. Journal of Neural Transmission, 126(11), 1561-1562.
- Lucassen, P. J., van Dam, A.-M., Kandel, P., Bielefeld, P., Korosi, A., Fitzsimons, C. P., & Maletic-Savatic, M. (2019). The orphan nuclear receptor TLX: an emerging master regulator of crosstalk between microglia and neural precursor cells. Neuronal Signaling , 3(2), Article NS20180208. https://doi.org/10.1042/NS20180208 [details]
- Zhao, J., Lucassen, P. J., & Swaab, D. F. (2019). Suicide Is a Confounder in Postmortem Studies on Depression. Biological Psychiatry, 86(10), e37-e40. https://doi.org/10.1016/j.biopsych.2019.04.015 [details]
2015
- Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., Krugers, H., & Joels, M. (2015). Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS ONE, 10(12), Article e0145706. https://doi.org/10.1371/journal.pone.0145706
2014
- Kuipers, S. D., Bramham, C. R., Cameron, H. A., Fitzsimons, C. P., Korosi, A., & Lucassen, P. J. (2014). Environmental Control of Adult Neurogenesis: From Hippocampal Homeostasis to Behavior and Disease. Neural Plasticity, 2014, 808643. https://doi.org/10.1155/2014/808643 [details]
2004
- Lucassen, P. J., Czeh, B., & Fuchs, E. (2004). Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biological Psychiatry, 55(8), 789-796. https://doi.org/10.1016/j.biopsych.2003.12.014 [details]
2021
- Kaiser, A., Bottelier, M. A., de Ruiter, M. B., Solleveld, M. M., Tamminga, H. G. H., Bouziane, C., Geurts, H. M., Lindauer, R. J. L., Kooij, J. J. S., Lucassen, P. J., Schrantee, A., & Reneman, L. (2021). Effects of prolonged methylphenidate treatment on amygdala reactivity and connectivity: a randomized controlled trial in stimulant treatment-naive, male participants with ADHD. Psychoradiology, 1(3), 152-163. https://doi.org/10.1093/psyrad/kkab013 [details]
2020
- Lucassen, P. J. (2020). Nieuwe zenuwcellen in volwassen hersenen; adulte neurogenese en haar rol bij hersenfuncties en -ziektes. Neuron. Nederlandse ed., 25(10), 34-38. https://www.neuron.be/nl/nieuws/medisch-nieuws/nieuwe-zenuwcellen-in-volwassen-hersenen-adulte-neurogenese-en-haar-rol-bij-hersenfuncties-en-ziektes.html [details]
2015
- Bolijn, S., & Lucassen, P. J. (2015). How the body talks to the brain; peripheral mediators of physical activity-induced proliferation in the adult hippocampus. Brain Plasticity, 1(1), 5-27. https://doi.org/10.3233/BPL-150020 [details]
2008
- Lucassen, P. J., Verbeek, E. C., & Oomen, C. A. (2008). Wat doen die nieuwe hersencellen daar? Neurogenese en celdood in volwassen hersenen. BLIND : Interdisciplinair Tijdschrift, 15. http://www.ziedaar.nl/article.php?id=303 [details]
2000
- Lucassen, P. J., Negoescou, A., Labat-Moleur, F., & van Lookeren Campagne, M. (2000). Microwave enhanced in situ end labelling of apoptotic cells in tissue sections; pitfalls and possibilities. In J. G. C.R. Taylor S.R. Shi (Ed.), Antigen Retrieval Techniques (Biotechniques series Eaton Publishing.
2015
- Yam, K. Y., Schipper, L., Naninck, E. F. G., la Fleur, S. E., Oosting, A., van der Beek, E. M., Lucassen, P. J., & Korosi, A. (2015). Involvement of fat metabolism in the early-life stress induced cognitive impairments. Psychoneuroendocrinology, 61, 34. https://doi.org/10.1016/j.psyneuen.2015.07.481
Prize / grant
- Lucassen, P. & Huitinga, I. (2024). NWO Gravitation grant.
- Lucassen, P. (2014). SILS Research prize.
- Lucassen, P. (1997). Organon Prize for Endocrinology 1997.
Membership / relevant position
- Lucassen, P. (2019-). board member of the new UvA Research Priority Area 'Urban Mental Health’, . https://www.uva.nl/en/shared-content/zwaartepunten/en/urban-mental-health/urban-mental-health.html
- Lucassen, P. J. (2019). Invited international Faculty Opponent for the PhD thesis of Francesca Marchisella, with host Prof.dr. Eleanor Coffey, Turku Centre for Biotechnology, University of Turku, Finland.
- Lucassen, P. J. (2017). Invited international Faculty Opponent for the PhD thesis of C Von Lindow, promotor; Prof.dr. B. Finsen and Prof.Dr. M West, Aarhus University.
- Lucassen, P. J. (2017). member, ECNP Program Committee.
- Lucassen, P. J. (2017). board member, Amsterdam Neuroscience.
- Lucassen, P. J. (2017). board member, Graduate School Neurosciences Amsterdam (ONWAR) .
- Lucassen, P. J. (2017). member Raad van Advies, Stress.
- Lucassen, P. J. (2016-). Fellow and Programme committee member ECNP, ECNP.
- Lucassen, P. J. (2016-). Review panel member for Research Council Norway ., Research Council Norway.
- Lucassen, P. J. (2016-). Review panel member for Donders Institute, Donders Institute.
- Lucassen, P. J. (2016-). Review panel member for ABC, Amsterdam Brain and Cognition UvA.
- Lucassen, P. J. (2016-). Review panel member for ANR, ANR.
- Lucassen, P. J. (2016-). Review panel member for SFI, SFI.
- Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board of the Campagneteam Huntington, Huntington.
- Lucassen, P. J. (2016-2017). Chairman of the Scientific Advisory Board, Alzheimer Nederland.
- Lucassen, P. J. (2015). reviewer Amsterdam Brain & Cognition, Amsterdam Brain & Cognition.
- Lucassen, P. J. (2015). reviewer for MRC/Welcome Trust, UK, MRC/Welcome Trust, UK.
- Lucassen, P. J. (2015). reviewer AMC fellowships, AMC.
- Lucassen, P. J. (2015). reviewer for Alzheimer Nederland, Alzheimer Nederland.
- Lucassen, P. J. (2015). reviewer for for France ANR, France ANR.
- Lucassen, P. J. (2015). Invited member of the Review committiee and site visit member of the labs of Dr Y. Nolan and Prof.Dr J. Cryan, UCC Cork, Ireland.
- Lucassen, P. J. (2015). reviewer for the NWO VENI committee, NWO, The Hague.
- Lucassen, P. J. (2015). reviewer the Kings Health Partners R&D Challenge Fund, the Kings Health Partners.
- Lucassen, P. J. (2014). Coordinator of the master track Psychopharmaca and Pathophysiology, University of Amsterdam.
- Lucassen, P. J. (2014). Chairman of the Scientific Advisory board of the International Society Alzheimer Onderzoek, ISAO.
- Lucassen, P. J. (2012-2013). Co-founder and co-organizer of the EUROGENESIS consortium meeting in Bordeaux, the EUROGENESIS consortium meeting in Bordeaux.
- Lucassen, P. J. (2012-2013). Faculty Opponent, Karolinska Institute, Stockholm, Sweden.
Media appearance
- Lucassen, P. J. (08-02-2017). plastic adult brain [Radio] Radio 1 NOS. plastic adult brain.
- Lucassen, P. J. (27-07-2016). Neurogenesis and Exercise [Radio] http://www.nporadio1.nl/sportzomer-2016/onderwerpen/367580-bewegen-stimuleert-aanmaak-hersencellen. Neurogenesis and Exercise.
- Lucassen, P. J. (01-01-2015). Nieuwe cellen, nieuwe verbindingen [Print]. Nieuwe cellen, nieuwe verbindingen.
Journal editor
- Lucassen, P. (editor) (2020). eLife (Journal).
- Lucassen, P. J. (editor) (2016-2017). Stress - the International Journal on the Biology of Stress (Journal).
- Lucassen, P. J. (editor) (2016-2017). PLoS ONE (Journal).
- Lucassen, P. J. (editor) (2016-2017). Neuroscience (Journal).
- Lucassen, P. J. (editor) (2016-). Brain Plasticity (Journal).
- Lucassen, P. J. (editor) (2015). Stress - the International Journal on the Biology of Stress (Journal).
- Lucassen, P. J. (editor) (2015). Neuroscience (Journal).
- Lucassen, P. J. (editor) (2015). PLoS ONE (Journal).
- Lucassen, P. J. (editor) (2014). Neuroscience (Journal).
- Lucassen, P. J. (editor) (2014). Stress - the International Journal on the Biology of Stress (Journal).
- Lucassen, P. J. (editor) (2014). Neural Plasticity (Journal). http://www.hindawi.com/journals/np/si/526861
- Lucassen, P. J. (editor) (2010). Translational Neuroscience (Journal).
- Lucassen, P. J. (editor) (2010). Frontiers in Neuroscience (Journal).
- Lucassen, P. J. (editor) (2009). Frontiers in Neuroscience (Journal).
Talk / presentation
- Lucassen, P. J. (speaker) (28-9-2020). Brain plasticity, (early) stress, nutrition and Alzheimer’s disease, Erasmus University.
- Lucassen, P. J. (speaker) (13-9-2020). Brain plasticity in relation to early life stress and nutrition, ECNP conference.
- Lucassen, P. J. (speaker) (19-6-2020). Neurobiology of Alzheimer’s disease.
- Lucassen, P. J. (speaker) (22-1-2020). Brain plasticity, (early) stress and Alzheimer’s disease, VUmc.
- Lucassen, P. J. (speaker) (7-1-2020). Brain Plasticity, neurogenesis, stress and disease.
- Lucassen, P. J. (speaker) (19-12-2019). Hersenonderzoek in de praktijk, Herman Wesselink College, Amstelveen.
- Lucassen, P. J. (speaker) (21-11-2019). Hersenonderzoek in de praktijk, Montessori Lyceum Amsterdam.
- Lucassen, P. J. (speaker) (19-11-2019). Neurobiology of Alzheimer’s disease; recent developments’, TNO BPRS Rijswijk.
- Lucassen, P. J. (speaker) (5-10-2019). Brain plasticity in relation to (early life) stress, nutrition and dementia., Julius-Maximilians-Universität Würzburg.
- Lucassen, P. J. (speaker) (14-5-2019). What does stress do to your brain?.
- Lucassen, P. J. (speaker) (28-1-2019). Brain plasticity in relation to early life stress, nutrition and major depression’, University College Cork.
- Lucassen, P. J. (speaker) (8-10-2018). The latest developments in Alzheimer’s research in his Highlight on Dementia., 31st ECNP Congress - Barcelona 2018
, Barcelona. - Lucassen, P. J. (invited speaker) (7-6-2018). Neurogenesis, (early) stress and depression, Dutch Neuroscience Meeting, Lunteren.
- Lucassen, P. J. (invited speaker) (17-5-2018). Brain plasticity in relation to (early) stress, nutrition and depression’, Institute Italiano di Tecnologica in Genova.
- Lucassen, P. J. (invited speaker) (2-2-2018). Effects of early life stress and nutrition on later brain plasticity and disease vulnerability., MQ mental health meeting, London, 2 feb 2018, Londen.
- Lucassen, P. J. (speaker) (31-10-2017). Our brain under stress., Academic Medical Center (AMC).
- Lucassen, P. J. (speaker) (25-10-2017). Stem cells, hippocampal neurogenesis, stress and depression., Department of Psychiatry Athens.
- Lucassen, P. J. (speaker) (24-10-2017). New neurons in, and for, adult brains; environmental regulation and functional roles., Athens University.
- Lucassen, P. J. (speaker) (5-9-2017). 'Exercise and psychiatric disease; should patients take the challenge?, 30th ECNP Congress - Paris 2017, Paris.
- Lucassen, P. J. (speaker) (30-5-2017). Stress effects on the brain, Pawlik Congres – 'Presteren onder Druk', Amsterdam. https://www.mindyourbrain.be/2017/05/30/presteren-druk-pawlik-congres-amsterdam-3052017/
- Lucassen, P. J. (speaker) (20-5-2017). Regulation of neurogenesis by stress and antidepressants., Adult primate neurogenesis, Varna.
- Lucassen, P. J. (speaker) (9-3-2017). Structural plasticity in relation to depression and dementia., Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark.
- Lucassen, P. J. (speaker) (7-2-2017). An overview of Alzheimer research; the state of the affairs, Netherlands Institute for Neuroscience NIN - KNAW.
- Lucassen, P. J. (speaker) (20-1-2017). Structural hippocampal plasticity and neurogenesis in relation to dementia, Alzheimer Center, Free University Medical Center, Amsterdam.
- Lucassen, P. J. (speaker) (2-12-2016). Neurogenesis and Alzheimer, Neurodegeneration symposium, Maastricht.
- Lucassen, P. J. (invited speaker) (10-9-2016). Hippocampal plasticity, (early) stress and depression., Invited lecture at ISPNE meeting ., Miami USA.
- Lucassen, P. J. (invited speaker) (19-7-2016). (Early) stress effects on neurogenesis and plasticity., Invited lecture at the the meeting of the British Psychopharmacology Association (BAP),, Brighton, United Kingdom.
- Lucassen, P. J. (invited speaker) (13-7-2016). Structural plasticity changes in relation to (early) stress, nutrition and depression, Invited lecture at 3rd Eurogenesis conference in Bordeaux, Bordeaux, France.
- Lucassen, P. J. (invited speaker) (4-6-2016). Nieuwe zenuwcellen voor het volwassen brein., Invited University of Amsterdam lecture at the Universiteitsdag, location Oudemanhuispoort, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (13-5-2016). New neurons in adult brains; an emerging substrate for brain plasticity programmed during early life., Invited plenary lecture at at the Spring conference on 'Neuroplasticity & Cognitive Reserve' of the Dutch Association for NeuroPsychology, (host; Prof.Dr. B. Schmand), Utrecht, The Netherlands.
- Lucassen, P. J. (invited speaker) (25-4-2016). Structural plasticity and neurogenesis in relation to (early) stress, depression and dementia., Invited lecture at Department of Neuroscience, Universitat de Valencia, (host; Dr. J. Nacher)., Valencia, Spain.
- Lucassen, P. J. (invited speaker) (13-4-2016). Round-Table Discussion on Chronic Early-Life Stress modelling, Invited participant/discussant Round Table Expert meeting on Early Life Stress, at the 'Neurobiology of Stress' conference, 12-14 April, Newport Beach, Irvine, USA.
- Lucassen, P. J. (invited speaker) (15-3-2016). Ins and outs of Adult Neurogenesis., Invited lecture at 5th Biennial ICCTF Meeting, Netherlands Cancer Institute Amsterdam, (host; Dr. S. Schagen)., Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (22-1-2016). Hippocampal plasticity in relation to early stress, nutrition and depression., Invited lecture at 2016 IBRO Workshop, organized by the Hungarian Academy of Sciences., Budapest, Hungary.
- Lucassen, P. J. (invited speaker) (14-1-2016). Plasticity changes in relation to (early) stress, depression and dementia., Invited lecture at Danish Academy, Aarhus University, Aarhuis, Denmark.
- Lucassen, P. J. (speaker) (15-12-2015). Nieuwe cellen in het volwassen brein; stamcellen en sport., Invited lecture at at the Opening Symposium of the "Exercise and the brain" week (supported by the Cruyff foundation) at the Amstelveen College highschool, Amstelveen, The Netherlands.
- Lucassen, P. J. (invited speaker) (16-11-2015). Early life stress, neurogenesis and behaviour., Invited lecture at the Colston Research Society Symposium 2015 on PTSD. Hosts; Prof.Dr. Hans Reul, prof.Dr. Astrid Linthorst, Bristol, United Kingdom.
- Lucassen, P. J. (invited speaker) (1-10-2015). Structural plasticity in relation to early stress, nutrition and depression., Plenary lecture ECNP supported at the 8th Symposium Psiquiatria de Braga at the University of Minho, Braga, Portugal.
- Lucassen, P. J. (invited speaker) (17-9-2015). Hippocampal plasticity in relation to (early) stress, nutrition and depression., Invited lecture at the Adult Neurogenesis meeting., Sernhac, France.
- Lucassen, P. J. (invited speaker) (1-7-2015). Science matters; stress & stem cells., Invited lecture at the Biomedical Symposium Radboud Universiteit Nijmegen., Nijmegen, The Netherlands.
- Lucassen, P. J. (invited speaker) (1-6-2015). Application of MRS as tool to measure adult neurogenesis in the live human brain., Invited lecture at ABC conference., Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (28-5-2015). Structural plasticity, (early) stress, antidepressants and major depression., Invited lecture at the symposium on the occasion of Dr Snezana Milanovic at the AMC., Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (10-4-2015). Structural plasticity in relation to (early) stress and depression., Invited lecture at the session on "Structural dynamics of adult neurogenesis" at the 17th International Neuroscience Winter Conference (host; Dr. S. Schwarzarcher), Solden, Switzerland.
- Lucassen, P. J. (invited speaker) (4-3-2015). Hippocampal plasticity in relation to early stress, nutrition and depression., Invited lecture at the Department of Anatomy, ETH (hosts; Dr I Amrein, M Van Dijk, Zurich, Switzerland.
- Lucassen, P. J. (invited speaker) (4-3-2015). Structural plasticity in relation to (early) stress, depression and dementia., Invited lecture at the Department of Fundamental Neurosciences, University of Lausanne (host; Dr. N. Toni), Lausanne, Switzerland.
- Lucassen, P. J. (invited speaker) (17-2-2015). Plasticity in relation to stress and neurogenesis., Invited lecture at the King's College London, Host; Dr Sandrine Thuret, London, United Kingdom.
- Lucassen, P. J. (invited speaker) (16-2-2015). Effects of early life stress and nutrition on adult hippocampal plasticity and function., Invited lecture at the MRCSocial, Genetic and Developmental Psychiatry Centre (host; Dr Geoff Bird), Institute of Psychiatry, King's College, London, United Kingdom.
- Lucassen, P. J. (invited speaker) (28-1-2015). Trends in Alzheimer's disease research, a personal perspective., Invited lecture at the ISAO Meet and Greet meeting, Utrecht, The Netherlands.
- Lucassen, P. J. (invited speaker) (15-1-2015). Structural plasticity in relation to (early) stress, nutrition and depression., Invited lecture at the department of Klinische NeuroAnatomie, Goethe Universitat, Host Dr. S. Schwarzacher, Frankfurt am Main, Germany.
- Lucassen, P. J. (invited speaker) (15-12-2014). Alzheimer onderzoek, de stand van zaken, Invited lecture at the Board of Advisors meeting of the Internationale Stichting Alzheimer Onderzoek ISAO, Breda, The Netherlands.
- Lucassen, P. J. (invited speaker) (6-11-2014). Addressing pressing neurobiological questions using postmortem human brain tissue, Invited lecture at Netherlands Brain Bank Psychiatry consortium meeting, NIN Amsterdam, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (6-10-2014). State of the affairs in Alzheimer research, Invited lecture at the ISAO board meeting, Utrecht, The Netherlands.
- Lucassen, P. J. (invited speaker) (19-9-2014). Changes in neurogenesis in relation to ritalin, fluoxetine and the 1.28 ppm MRS peak., Invited lecture at PRIOMED meeting, Rome, Italy.
- Lucassen, P. J. (invited speaker) (7-9-2014). Food and stress effects during brain development., Invited lecture at the Route28 meeting, Chiemsee, Germany.
- Lucassen, P. J. (invited speaker) (16-6-2014). Brain Development., Opening lecture at the Summer School on 'Early life; genes and brain development UvA/IIS, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (14-6-2014). Plasticity changes in the brain following stress., Invited lecture Dutch Biomedical Student Conference; BIC Lecture, UMC Utrecht, Utrecht, The Netherlands.
- Lucassen, P. J. (invited speaker) (10-6-2014). Alzheimer research, stam cells, exercise and vaccination., Invited lectureat the Alzheimer Cafe Voorburg, Voorburg, The Netherlands.
- Lucassen, P. J. (invited speaker) (21-5-2014). Neurogenesis in the live human brain; possibilities for detection by Magnetic Resonance Spectroscopy., Invited lecture at the Netherlands Cancer Institute, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (30-4-2014). Plasticity changes in relation to early nutrition, exercise and Alzheimer's disease., Invited lecture Dept Anatomy, University of Munich, Munich, Germany.
- Lucassen, P. J. (invited speaker) (30-4-2014). Plasticity changes in relation to (early life) stress, nutrition and depression., Invited lecture for the Department of Molecular Neurology of the University Hospital Erlangen, Erlangen, Germany.
- Lucassen, P. J. (invited speaker) (29-4-2014). Doublecortin and doublecortin-like as important players in early cortical development., Invited 'GrassRoot' lecture at the University of Erlangen; Host; Prof.Dr. J Winkler., Erlangen, Germany.
- Lucassen, P. J. (invited speaker) (10-2-2014). Structural plasticity in relation to (early life) stress, nutrition and depression., Invited lecture at the 5th Brain Behav Society "Good stress, bad stress and very bad stress", Haifa, Israel.
- Lucassen, P. J. (invited speaker) (22-1-2014). Effects of early stress and food on adult hippocampal plasticity and function., Invited Lecture at at the Netherlands Institute for the Advancement of Social and Humanities Science (NIAS), Wassenaar, The Netherlands.
- Lucassen, P. J. (invited speaker) (16-12-2013). Plasticity changes in relation to early life stress and depression., Invited lecture at the Instututo Superior de Sanita, Rome, Rome, Italy.
- Lucassen, P. J. (invited speaker) (18-11-2013). Plasticity changes in relation to early stress, depression and dementia., Invited Lecture at ETH Swiss Institute for Brain Research, Zurich, Host; Prof.Dr. Isabelle Mansuy, Zurich, Switzerland.
- Lucassen, P. J. (invited speaker) (22-9-2013). Introductory lecture for the movie "Vergiss mich nicht"., Introductory lecture for the movie "Vergiss mich nicht" on the occasion of World Alzheimer day, Ketelhuis Cinema, Amsterdam, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (17-9-2013). Structural plasticity in relation to early life stress., invited lecture at at the PRIOMED meeting, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (4-9-2013). Structural plasticity in the adult brain in relation to (early) stress and disease., invited lecture at the VUMC Amsterdam, host Dr M. Huizinga, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (26-6-2013). Structural and functional plasticity in relation to early stress and Alzheimer's disease., invited lecture at the EUROGENESIS meeting in Bordeaux, Bordeaux, France.
- Lucassen, P. J. (invited speaker) (28-2-2013). Nieuwe cellen van, en voor, het oude brein., invited lectureSPUI 25, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (21-11-2012). Neurobiological insight in Alzheimer's disease; one step forward, two steps back., invited lecture at the University Groningen, Groningen, The Netherlands.
- Lucassen, P. J. (invited speaker) (24-10-2012). Lasting effects of early and later stress on structural plasticity., invited talk at the EUROGENESIS meeting, Paris, France.
- Lucassen, P. J. (invited speaker) (14-10-2012). Neurogenesis, major depression and antidepressants; a relevant link?, invited lecture at the Brainstorming session, ECNP meeting, Wien, Austria.
- Lucassen, P. J. (invited speaker) (2-10-2012). Nieuwe cellen voor het oudere brein; effecten van stress en sport, invited public lecture Alzheimer Meeting, Wijchen, The Netherlands.
- Lucassen, P. J. (invited speaker) (18-9-2012). Structural and functional plasticity in relation to Alzheimer's disease., invited lecture at the Fall Global Discovery Meeting at Johnson&Johnson, Beersum, Belgium.
- Lucassen, P. J. (invited speaker) (13-7-2012). Structural plasticity in relation to early life stress., invited lecture at the EBBS satelite "Stress and our social lives", Barcelona, Spain.
- Lucassen, P. J. (invited speaker) (4-7-2012). Effects of early stress and food on adult hippocampal plasticity and function., invited lecture at the Danone Nutricials, Ede, The Netherlands.
- Lucassen, P. J. (invited speaker) (22-6-2012). Structural plasticity changes in relation to early stress or psychoactive drug treatment., invited lecture at the European PRIOMED meeting, Caen, France.
- Lucassen, P. J. (invited speaker) (7-5-2012). Animal models for Alzheimer's disease; where have we come from and are we there yet ?, invited lecture at the Neurodegeneration ONWA meeting, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (19-4-2012). Structural plasticity in relation to stress, age, dementia and depression, invited lecture at the EURON Neuroscience Meeting, Braha, Portugal.
- Lucassen, P. J. (invited speaker) (19-4-2012). Structural plasticity in relation to stress, age, dementia and depression, invited lecture at the EURON Neuroscience Meeting, Braha, Portugal.
- Lucassen, P. J. (invited speaker) (9-3-2012). Neurogenesis in depression?, invited lecture at the International Conference Controverses in Neuroscience CONY, Wien, Austria.
- Lucassen, P. J. (invited speaker) (25-2-2012). Adult neurogenesis, stress and depression, invited lecture at the Karolinska Institute, Stockholm, Sweden.
- Lucassen, P. J. (invited speaker) (6-2-2012). New neurons in old brains., invited lecture at the Faculty Colloquiem Universiteit van Amsterdam, Amsterdam, The Netherlands.
- Lucassen, P. J. (invited speaker) (31-1-2012). Early stress and neurogenesis, invited lecture at the University Maastricht, Maastricht, The Netherlands.
- Lucassen, P. J. (invited speaker) (28-1-2012). Adult structural plasticity in relation to stress, depression and dementia, invited lecture at Eurogenesis meeting, Les Diablerets, Switzerland.
- Lucassen, P. J. (speaker) (11-11-2010). Mouse models for Alzheimer; where have we come from and are we there yet?, Invited Lecture at the ISAO workshop., San Diego, USA.
- Lucassen, P. J. (speaker) (10-11-2010). "Alzheimer's disease 2011; the state of affairs"., Plenary introductory lecture for the ISAO Alzheimer workshop, San Dïego, USA.
- Lucassen, P. J. (speaker) (14-10-2010). Stress and new brain cells., Invited Lecture at the Dutch Publieksdag of the Dutch Brain Foundation., Utrecht, The Netherlands.
- Lucassen, P. J. (speaker) (30-9-2010). Neurogenesis in Alzheimer (models), Invited Lecture at the INSERM Neurogenesis Meeting, Bordeaux, France.
- Lucassen, P. J. (speaker) (31-8-2010). Alzheimer’s disease: neurogenesis and enriched environment; promising avenues?, Lecture at the ECNP Brain stoming session, Amsterdam, The Netherlands.
- Lucassen, P. J. (speaker) (20-5-2010). Structural plasticity in relation to (early) stress and depression., Invited lecture at the Institute for Neuroscience and Academic Psychiatry, Medical School, New Castle, U.K.
- Lucassen, P. J. (speaker) (15-3-2010). Structural plasticity in dementia., Lecture at the International NEURAD meeting, Amsterdam, the Netherlands.
- Lucassen, P. J. (speaker) (25-1-2010). Stem cells in the adult brain., invited lecture Graduate School BCN, Groningen, The Netherlands.
- Lucassen, P. J. (speaker) (2-12-2009). Structural plasticity in dementia (models)., NEURAD Meeting, Leuven, Belgium.
- Lucassen, P. J. (speaker) (29-7-2009). Structural plasticity and neurogenesis in relation to stress and depression., The British Association for Psychopharmacology Meeting, Oxford, UK.
- Lucassen, P. J. (speaker) (5-6-2009). Doublecortin-like proteins during development and in developmental pathologies., ENP Meeting, Doorwerth, the Netherlands.
- Lucassen, P. J. (speaker) (4-6-2009). Changes in neurogenesis in Alzheimer (models)., EndoNeuroPsycho ENP Meeting, Doorwerth, the Netherlands.
- Lucassen, P. J. (speaker) (26-1-2009). Neurogenesis in relation to Alzheimer’s disease and mouse models for dementia., Winterschool on Neuroscience, Colorado, USA.
- Lucassen, P. J. (speaker) (22-1-2009). Neurogenesis, stress and depression., Winter Conference on Neuroscience, Virgin Islands, USA.
- Lucassen, P. J. (speaker) (12-1-2009). Stem cells in the adult brain., Graduate School BCN, Groningen, the Netherlands.
- Lucassen, P. J. (speaker) (3-12-2008). Expression of doublecortin and doublecortin-like during early cortical development and in human brain., NCMLS, University of Nijmegen, Nijmegen, The Netherlands.
- Lucassen, P. J. (speaker) (13-11-2008). Update on Alzheimer’s disease, EURON PhD Workshop on “Animal models to mimic and understand Alzheimer’s disease etiology” at the Society for Neuroscience premeeting, Washington, USA.
- Lucassen, P. J. (speaker) (18-9-2008). Structural plasticity during early development and in the Alzheimer brain, 2nd NEURAD Summer School, Leuven, Belgium.
- Lucassen, P. J. (speaker) (1-9-2008). Neurogenesis in relation to aging and dementia, ECNP Meeting, Barcelona, Spain.
- Lucassen, P. J. (speaker) (5-6-2008). Doublecortin proteins in human brain, EndoNeuroPsycho Meeting, Doorwerth, The Netherlands.
- Lucassen, P. J. (speaker) (21-5-2008). Voor- en nadelen van een demente muis, ISAO Meeting, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
- Lucassen, P. J. (speaker) (21-4-2008). Alzheimer Mouse models; where have we come from and are we there yet ?, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
- Lucassen, P. J. (speaker) (14-4-2008). Neurogenesis in relation to dementia, Bilateral Paris-Amsterdam NEURAD Meeting, Paris, France.
- Lucassen, P. J. (speaker) (3-4-2008). Zit stress tussen de oren ?, lezing bij het proefstuderen, Amsterdam, the Netherlands.
- Lucassen, P. J. (speaker) (28-3-2008). Structural hippocampal plasticity in relation to dementia, Bilateral Amsterdam-Gottingen NEURAD meeting, Dept Psychiatry, Gottingen University, Gottingen, Germany.
- Lucassen, P. J. (speaker) (14-3-2008). "Effects of perinatal stress exposure on behaviour, endocrinology and adult neurogenesis in 2 rat lines that differ in stress coping style and anxiety related behaviour, VW Statussymposium, Tubingen, Germany.
- Lucassen, P. J. (speaker) (10-3-2008). Nieuwe ontwikkelingen in het hersenonderzoek naar stress en stam cellen, the Dutch Brain Awareness week at the Jac.P. Thijsse college, Castricum, the Netherlands.
- Lucassen, P. J. (speaker) (29-2-2008). Can we determine neurogenesis in the human brain, Stem cell meeting at the Netherland Institute for Neuroscience, Amsterdam, the Netherlands.
- Lucassen, P. J. (speaker) (22-2-2008). Neurogenesis in relation to stress, depression and dementia, Amsterdam-Groningen bilateral meeting, Amsterdam, The Netherlands.
- Lucassen, P. J. (speaker) (22-1-2008). Neurogenesis, Stress and Depression, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
- Lucassen, P. J. (speaker) (21-1-2008). Neurogenesis and hippocampal function in Alzheimer’s disease, Wuhan Institute for Neuroscience and Neuroengineering (WINN), South-center University for Nationalities, Wuhan, China.
- Lucassen, P. J. (speaker) (4-12-2007). Cellular plasticity changes in relation to stress and dementia., Invited Lecture at the Department of Psychiatry, Gottingen University, host: Prof.Dr. T. Bayer, Gottingen in Duitsland.
- Lucassen, P. J. (speaker) (28-11-2007). Structural plasticity and neurogenesis in relation to stress and depression., Emile Kraepelin Professorship to Marian Joels bij het Max Planck Inst. for Psychiatry, Munchen, Duitsland.
- Lucassen, P. J. (speaker) (10-10-2007). The role of neurogenesis in antidepressant action., invited discussant at the Targeted Expert Meeting preceding the ECNP stress meeting, Wenen Oostenrijkk.
- Lucassen, P. J. (speaker) (10-10-2007). Neurogenesis in neuropsychiatric disorders., Invited lecture at the Targeted Expert Meeting prior to the ECNP meeting in Vienna, Wenen, Oostenrijk.
- Lucassen, P. J. (speaker) (21-9-2007). Regulation of cellular plasticity by stress and dementia., 1st NEURAD summer school, Gottingen, Duitsland.
- Lucassen, P. J. (speaker) (4-6-2007). Changes in neurogenesis in dementia; are they functionally relevant?, BCN International Stem cell symposium, Groningen.
- Lucassen, P. J. (speaker) (21-5-2007). Increases in LTP and learning but not neurogenesis in young P301L tau mutant mice., Talk at the symposium "Modeling neuro-degeneration: causes and consequences", of the 9th Annual Genes, Brain and Behavior Meeting - IBANGS 2007, Doorwerth.
- Lucassen, P. J. (speaker) (14-5-2007). Alzheimer mouse models; where have come from and are we there yet?, Meeting: the Internationale Stichting Alzheimer Onderzoek in Bad Honnef, Bonn, Duitsland.
- Lucassen, P. J. (speaker) (2-4-2007). Does depression damage the brain?, Conference on Depression: Causes in the Brain, Consequences on the Body. Organized by the Institute of Psychiatry, King's College London, Royal Society of Medicine, London Engeland.
- Lucassen, P. J. (speaker) (12-1-2007). Changes in neurogenesis in relation to dementia., NEURAD Kick off symposium, Berlijn Duitsland.
- Lucassen, P. J. (speaker) (1-11-2006). Changes in neurogenesis and hippocampal function in tau transgenic mice, lezing geven op uitnodiging van Dr. Kempermann bij het Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch, Germany, Berlijn, Duitsland.
- Lucassen, P. J. (speaker) (1-11-2006). Doublecortin-like; a microtubule associated protein involved in mitotic spindle and radial fiber stability of radial glia cells during early cortical development., Invited lecture at the Max Delbruck Centre for Molecular MedicineDr. G. Kempermann, Berlin Duitsland.
- Lucassen, P. J. (speaker) (1-11-2006). Structural plasticity in the adult brain in relation to stress and disease., lezing geven op uitnodiging van Prof. Heuser bij de Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charite Campus Benjamin Franklin, University Berlin, Berlijn, Duitsland.
- Lucassen, P. J. (speaker) (11-10-2006). Doublecortin-like; a novel microtubule associated protein involved in mitotic spindle and radial fiber stability., lezing bij Stem Cell Cluster Groningen, Groningen University, Groningen.
- Lucassen, P. J. (speaker) (29-9-2006). Structural plasticity in the adult brain in relation to stress and disease., lezing bij Department of Molecular Neurobiology University of Groningen, Groningen.
- Lucassen, P. J. (speaker) (27-9-2006). Increases in LTP and learning but not neurogenesis in young P301L tau mutant mice, ISPNE meeting, Leiden.
- Lucassen, P. J. (speaker) (4-9-2006). Structural plasticity and adult neurogenesis in relation to stress and dementia., the Route 28 Summit in Neurobiology, Chiemfrausee, Duitsland.
- Lucassen, P. J. (speaker) (9-7-2006). Structural hippocampal plasticity in relation to stress and depression", FENS meeting, Wenen Oostenrijk.
- Lucassen, P. J. (speaker) (26-6-2006). Structural plasticity in relation to stress and depression., lezing bij The University of Bristol, United Kingdom, Bristol Engeland.
- Lucassen, P. J. (speaker) (19-5-2006). Doublecortin-like, a novel microtubule associated protein expressed in radial glia is crucial for neuronal precursor division and radial process stability during early corticogenesis, Neuronal Developmental Disorders meeting, Doorwerth.
- Lucassen, P. J. (speaker) (20-1-2006). Alzheimer’s disease; the state-of-affairs., NIBI meeting on The Biology of Memory, Lunteren.
- Lucassen, P. J. (speaker) (16-1-2006). Neurogenesis and stem cells in the adult brain., lezing bij Department of Medical Physiology, University Medical Centre Groningen, Groningen.
- Lucassen, P. J. (speaker) (26-9-2005). Changes in neurogenesis, LTP and memory function in tau transgenic mice, symposium celebrating 10 years of AFI / ISAO, Frankfurt.
- Lucassen, P. J. (speaker) (16-9-2005). Structural dynamic plasticity in the hippocampus in relation to stress and depression, Psychopharmacology, Utrecht.
- Lucassen, P. J. (speaker) (14-6-2005). Changes in neurogenesis, LTP and memory function in tau transgenic mice, Netherlands Institute for Brain Research, Amsterdam.
- Lucassen, P. J. (speaker) (7-6-2005). Stress and hippocampal structural plasticity; possible mechanisms, INSERM U.588, Institut François Magendie, Bordeaux.
- Lucassen, P. J. (speaker) (29-3-2005). A novel Doublecortin-Like Protein, Expressed in Radial Glia of the Early Neocortex is Critical for Mitotic Spindle Stability of Neural Precursors, Rudolf Magnus Institute for Neuroscience, University of Utrecht, Utrecht.
- Lucassen, P. J. (speaker) (18-2-2005). Live and let die: neurogenesis and apoptosis in the stressed and depressed brain, 6th International Meeting of the German Neuroscience Society, 30th Göttingen Neurobiology Conference, Göttingen.
- Lucassen, P. J. (speaker) (22-11-2004). Structural dynamic changes in the hippocampus in relation to stress and depression., invited lecture at the Dep. Cellular Animal Physiology of the Radboud University, Nijmegen (Hosts: Dr. Tamas Kozicz, Prof.Dr. E. Roubos), Nijmegen.
- Lucassen, P. J. (speaker) (23-9-2004). Adult neurogenesis in relation to stress and depression, Invited Lecture at the FOS Master Course 2004 in Leiden (host; Dr E. Vreugdenhil), Leiden.
- Lucassen, P. J. (speaker) (3-9-2004). Structural dynamic changes in the hippocampus of tau mice; consequences for function ?, Invited Lecture at the Department of Psychiatry and Neuropsychology, University of Maastricht (Hosts: Dr. C. Schmitz and Prof.Dr. H.W. Steinbusch), Maastricht.
- Lucassen, P. J. (speaker) (31-8-2004). Functional roles of neurogenesis in the adult brain, Genomics for Our World" Program; Workshop on Neurogenesis & Neurogenomics, organized by the UK/Dutch Ambassy, Rotterdam.
- Lucassen, P. J. (speaker) (3-6-2004). Structural plasticity changes in major depression, lezing bij de sessie Adult neurogenesis and depression bij de EndoNeuroPsycho vergadering, Doorwerth.
- Lucassen, P. J. (speaker) (22-4-2004). New neurons in the adult brain; a possible role in learning ?, lezing bij de vereniging Studenten Psychologie Amsterdam VSPA lecture, Amsterdam.
- Lucassen, P. J. (speaker) (13-12-2003). Adult neurogenesis and apoptosis, FENS Winterschool 2003, Kitzbuhel.
- Lucassen, P. J. (speaker) (17-11-2003). Adult neurogenesis in relation to stress and depression, FOS symposium, Leiden.
- Lucassen, P. J. (speaker) (10-9-2003). Glucocorticoid receptor beta expression in the human hippocampus, NIBR, Amsterdam.
- Lucassen, P. J. (speaker) & Neumann, I. (speaker) (7-9-2003). Effects of pre- and postnatal environmental factors on cognitive function, hippocampal neurogenesis and emotionality; vulnerability to early life events., the 2nd Symposium of the Volkswagen Stiftung, Magdeburg.
- Lucassen, P. J. (speaker) (16-12-2002). Hippocampal neurogenesis in the adult brain: a function in learning processes, Neurofederation Automn Symposium, Amsterdam.
- Lucassen, P. J. (speaker) (13-11-2002). New cells in adult brains; a role in Alzheimer, International Stichting Alzheimar Onderzoek (ISAO), Rotterdam.
- Lucassen, P. J. (speaker) (22-10-2002). Adult neurogenesis and apoptosis in relation to early steroid exposure, stress and ageing, VW Stiftung symposium, Regensburg, Germany.
- Lucassen, P. J. (speaker) (26-9-2002). Stem cells in the adult brain; a functional role in learning?, Learning Processes Conference, Haren.
- Lucassen, P. J. (speaker) (21-5-2002). Adult neurogenisis and apoptosis in the hippocampus in relation to age, stress and disease, Centre Human Genetics, Leuven, Belgium.
- Lucassen, P. J. (speaker) (11-5-2002). Stem cells in the adult brain; (im)possibilities and applications, Ataxia Patients Society, Bunnik.
- Lucassen, P. J. (speaker) (8-5-2002). Apoptosis and Neurogenesis in the hippocampus, Elba Summer School, Italy.
- Lucassen, P. J. (speaker) (9-4-2002). Neurogenesis and apoptosis in the hippocampus, Capita Selecta, Leiden.
- Lucassen, P. J. (speaker) (30-1-2002). An overview and update on adult neurogenesis, Biological Centre, Haren.
- Lucassen, P. J. (speaker) (24-1-2002). Stem cells in the adult mammalian CNS, changes with aging and possible functional applications, EURON Winter school, Kerkrade.
- Lucassen, P. J. (speaker) (18-10-2001). New cells in old brains, Nationale Publieksdag Hersenonderzoek, Utrecht, The Netherlands.
- Lucassen, P. J. (speaker) (27-4-2001). Hippocampal apoptosis in major depression, Master Class SPINOZA chair to Prof.Dr.Dr. F. Holsboer, Amsterdam, The Netherlands.
- Lucassen, P. J. (speaker) (25-1-2001). Young and old cells in young and old brains: changes in hippocampal apoptosis and neurogenesis with aging, Hungarian Neuroscience Society Conference, Szeged, Hungary.
Others
- Lucassen, P. J. (participant) (10-2018). 31st ECNP Congress - Barcelona 2018, Barcelona. sessions organized and chaired by Paul Lucassen on 'New advances in the therapy of Huntington’s and Parkinson’s disease’. (participating in a conference, workshop, ...).
- Lucassen, P. J. (other) (1-1-2016). a novel Erasmus training program with University Athens (other).
- Lucassen, P. (other) (30-8-2009 - 30-1-2018). Chair SAB Alzheimer Nederland (other).
- Lucassen, P. (other) (2009 - 2018). Member and chair of the SAB Alzheimer Nederland (other).
2025
- Geertsema, J. I. (2025). Early nutritional strategies to modulate the early-life stress- and Alzheimer's disease-induced changes in the brain: Focus on microglia. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Penning, A. R. A. (2025). Small RNA, big impact: Profiling the therapeutic potential of microRNA-132 in Alzheimer's disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Tosoni, G. (2025). New neurons, old questions: Cellular and molecular insights into the neurogenesis debate in Alzheimer’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2024
- Brosens, A. A. D. (2024). Stress effects on the developing and adult brain: Synaptic and network mechanisms underlying memory and disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Juncker, H. G. (2024). A human milk perspective on the transmission of maternal factors to her child: Focus on stress, nutrition and immunity. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2023
- Kaiser, A. (2023). Challenging the brain: Insights from comprehensive structural & functional MRI studies. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Kotah, J. M. (2023). Age-dependent impact of early-life stress on glia and synapses: Substrates for increased risk for Alzheimer’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Zhang, L. (2023). Molecular pathology of suicide: A postmortem study. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2022
2021
2020
2019
- Abbink, M. R. (2019). Programming of the brain by early-life stress: The impact of early nutritional interventions and later life challenges. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Lesuis, S. L. (2019). Stress and memory in health and disease: Impact on Alzheimer's disease and memory mechanisms. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2018
- Beex, L. M. (2018). Reactive gliosis at the tripartite synapse: Functional characterization of astrocytes in a model of Alzheimer’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Hoeijmakers, L. (2018). Consequences of early-life stress for microglia throughout life: Relevance for the hippocampus in aging and Alzheimer’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Solleveld, M. M. (2018). Psychotropic medications and the developing brain. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Yam, K.-Y. (2018). Programming of the brain by metabolic and nutritional factors after early-life stress: Modulations by early nutritional interventions. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Zhao, J. (2018). Prefrontal gene expression changes in mood disorders and suicide. [Thesis, externally prepared, Universiteit van Amsterdam]. [details]
2017
2016
- Schrantee, A. G. M. (2016). Detecting dopamine dysfunction with pharmacological MRI. [Thesis, fully internal, Universiteit van Amsterdam]. Uitgeverij BOXPress. [details]
- Wang, Q. (2016). The glucocorticoid receptor in the limbic system of the human brain. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2015
- Doorn, K. J. (2015). Brain region-specific microglial phenotypes and responses in Parkinson’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. Boxpress. [details]
- Naninck, E. F. G. (2015). Programming of hippocampal structure and function by early-life stress: Opportunities for nutritional intervention. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Schouten, M. (2015). Epigenetic control of hippocampal stem cells: modulation by hyperactivation, glucocorticoids and aging. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2012
2010
2006
2022
- Low, D. Y., Du Preez, A., Andres-Lacueva, C., Lefèvre-Arbogast, S., Sánchez-Pla, A., Lee, H., Lucassen, P., Manach, C., Aigner, L., Thuret, S., Korosi, A., Pallàs, M., Samieri, C., González-Domínguez, R., Ruigrok, S., Helmer, C., Castellano-Escuder, P. & Urpi-Sarda, M. (2022). Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline. figshare Academic Research System. https://doi.org/10.6084/m9.figshare.c.5775869.v1
- Aigner, L., Thuret, S., Andres-Lacueva, C., Low, D. Y., Lucassen, P., González-Domínguez, R., Pallàs, M., Lefèvre-Arbogast, S., Castellano-Escuder, P., Urpi-Sarda, M., Lee, H., Korosi, A., Du Preez, A., Samieri, C., Ruigrok, S., Helmer, C., Sánchez-Pla, A. & Manach, C. (2022). Additional file 1 of Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline. figshare Academic Research System. https://doi.org/10.6084/m9.figshare.17798657.v1
- Brouwer, M. E., Hofstee, L., van den Brand, S., Teijema, J., Melnikov, V., de Boer, J., Lucassen, P., de Bruin, J., van Weert, J., Ferdinands, G., Kramer, B., Weijdema, F., Sloot, P. M. A., Stronks, K., van Weert, J., Wiers, R., Bockting, C. L. H. & Schoot, R. . (2022). Final data for the mega meta project. DANS Data Station Life Sciences. https://doi.org/10.17026/dans-z7w-9446
- Brouwer, M. E., Hofstee, L., van den Brand, S., Teijema, J., Melnikov, V., de Boer, J., Lucassen, P., de Bruin, J., Ferdinands, G., Kramer, B., Weijdema, F., Sloot, P. M. A., Stronks, K., van Weert, J., Wiers, R., Bockting, C. & Schoot, R. . (2022). Pre-processing data for the Mega Meta Project. DANS Data Station Life Sciences. https://doi.org/10.17026/dans-29d-n6yg
2021
- Bielefeld, P., Davidson, A., Reijner, N., Abiega Etxabe, O., Lucassen, P. J., Fitzsimons, C. P., Abbink, M. R. & Korosi, A. (2021). Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus. Taylor & Francis. https://doi.org/10.6084/m9.figshare.14035256.v1
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Ancillary activities
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Lucassen, P. J., Korosi, A., de Rooij, S. R., Smit, A. B., Van Dam, A.-M., Daskalakis, N. P., Van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W., & Krugers, H. J. (2025). How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms. Biological Psychiatry, 97(4), 372-381.