Prof. dr. K.J. (Klaas) Hellingwerf
Faculty of Science
Swammerdam Institute for Life Sciences
Visiting address
- Science Park 904
Postal address
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Postbus 94232
1090 GE Amsterdam
Contact details
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Profile
Link to the website of the research group in the Swammerdam Institute
Brief professional curriculm vitae
In the attached document my research interests, successive scientific affiliations, and current formal responsibilities are described in summarized form
List of publications
link to Photanol BV
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Publications
- refereed (100)
- academic (9)
- professional (1)
- popular scientific (4)
- other output (1)
- supervised theses (2)
- datasets (1)
2020
Carpine, R., Olivieri, G., Hellingwerf, K. J., Pollio, A., & Marzocchella, A. (2020). Industrial Production of Poly-β-hydroxybutyrate from CO2: Can Cyanobacteria Meet this Challenge? Processes, 8(3), Article 323. https://doi.org/10.3390/pr8030323 [details]- Luimstra, V. M., Schuurmans, J. M., Hellingwerf, K. J., Matthijs, H. C. P., & Huisman, J. (2020). Blue light induces major changes in the gene expression profile of the cyanobacterium Synechocystis sp. PCC 6803. Physiologia Plantarum, 170(1), 10-26. https://doi.org/10.1111/ppl.13086 [details]
- Wu, W., Du, W., Gallego, R. P., Hellingwerf, K. J., van der Woude, A. D., & Branco Dos Santos, F. (2020). Using osmotic stress to stabilize mannitol production in Synechocystis sp. PCC6803. Biotechnology for Biofuels, 13, Article 117. https://doi.org/10.1186/s13068-020-01755-3 [details]
2019
- Chen, Q., Arents, J., Schuurmans, J. M., Ganapathy, S., de Grip, W. J., Cheregi, O., Funk, C., Branco Dos Santos, F., & Hellingwerf, K. J. (2019). Functional Expression of Gloeobacter Rhodopsin in PSI-Less Synechocystis sp. PCC6803. Frontiers in Bioengineering and Biotechnology, 7, Article 67. https://doi.org/10.3389/fbioe.2019.00067 [details]
- Chen, Q., Arents, J., Schuurmans, J. M., Ganapathy, S., de Grip, W. J., Cheregi, O., Funk, C., Dos Santos, F. B., & Hellingwerf, K. J. (2019). Combining retinal-based and chlorophyll-based (oxygenic) photosynthesis: Proteorhodopsin expression increases growth rate and fitness of a ∆PSI strain of Synechocystis sp. PCC6803. Metabolic Engineering, 52, 68-76. https://doi.org/10.1016/j.ymben.2018.11.002 [details]
- Du, W., Jongbloets, J. A., Guillaume, M., van de Putte, B., Battaglino, B., Hellingwerf, K. J., & Branco Dos Santos, F. (2019). Exploiting Day- and Night-Time Metabolism of Synechocystis sp. PCC 6803 for Fitness-Coupled Fumarate Production around the Clock. ACS Synthetic Biology, 8(10), 2263-2269. https://doi.org/10.1021/acssynbio.9b00289 [details]
- Luimstra, V. M., Schuurmans, J. M., de Carvalho, C. F. M., Matthijs, H. C. P., Hellingwerf, K. J., & Huisman, J. (2019). Exploring the low photosynthetic efficiency of cyanobacteria in blue light using a mutant lacking phycobilisomes. Photosynthesis Research, 141(3), 291–301. https://doi.org/10.1007/s11120-019-00630-z [details]
- Pérez, A. A., Chen, Q., Pineda Hernández, H., Branco Dos Santos, F., & Hellingwerf, K. J. (2019). On the use of oxygenic photosynthesis for the sustainable production of commodity chemicals. Physiologia Plantarum, 166(1), 413-427. https://doi.org/10.1111/ppl.12946 [details]
2018
- Acuña, A. M., van Alphen, P., Branco Dos Santos, F., van Grondelle, R., Hellingwerf, K. J., & van Stokkum, I. H. M. (2018). Spectrally decomposed dark-to-light transitions in Synechocystis sp. PCC 6803. Photosynthesis Research, 137(2), 307-320. https://doi.org/10.1007/s11120-018-0505-0 [details]
- Acuña, A. M., van Alphen, P., Branco Dos Santos, F., van Grondelle, R., Hellingwerf, K. J., & van Stokkum, I. H. M. (2018). Spectrally decomposed dark-to-light transitions in a PSI-deficient mutant of Synechocystis sp. PCC 6803. Biochimica et Biophysica Acta - Bioenergetics, 1859(2), 57-68. https://doi.org/10.1016/j.bbabio.2017.11.002 [details]
- Bury, A., & Hellingwerf, K. J. (2018). Design, characterization and in vivo functioning of a light-dependent histidine protein kinase in the yeast Saccharomyces cerevisiae. AMB Express, 8, Article 53. https://doi.org/10.1186/s13568-018-0582-7 [details]
- Chen, Q., van der Steen, J. B., Arents, J. C., Hartog, A. F., Ganapathy, S., de Grip, W. J., & Hellingwerf, K. J. (2018). Deletion of sll1541 in Synechocystis sp. Strain PCC 6803 Allows Formation of a Far-Red-Shifted holo-Proteorhodopsin In Vivo. Applied and Environmental Microbiology, 84(9), Article e02435-17. https://doi.org/10.1128/AEM.02435-17 [details]
- Cordara, A., Manfredi, M., van Alphen, P., Marengo, E., Pirone, R., Saracco, G., Branco Dos Santos, F., Hellingwerf, K. J., & Pagliano, C. (2018). Response of the thylakoid proteome of Synechocystis sp. PCC 6803 to photohinibitory intensities of orange-red light. Plant physiology and biochemistry : PPB, 132, 524-534. https://doi.org/10.1016/j.plaphy.2018.10.002 [details]
- Cordara, A., Re, A., Pagliano, C., Van Alphen, P., Pirone, R., Saracco, G., Branco dos Santos, F., Hellingwerf, K., & Vasile, N. (2018). Analysis of the light intensity dependence of the growth of Synechocystis and of the light distribution in a photobioreactor energized by 635 nm light. PeerJ, 6, e5256. https://doi.org/10.7717/peerj.5256 [details]
- Du, W., Caicedo Burbano, P., Hellingwerf, K. J., & Branco Dos Santos, F. (2018). Challenges in the Application of Synthetic Biology Toward Synthesis of Commodity Products by Cyanobacteria via "Direct Conversion". In W. Zhang, & X. Song (Eds.), Synthetic Biology of Cyanobacteria (pp. 3-26). (Advances in Experimental Medicine and Biology; Vol. 1080). Springer. https://doi.org/10.1007/978-981-13-0854-3_1 [details]
- Du, W., Jongbloets, J. A., van Boxtel, C., Pineda Hernández, H., Lips, D., Oliver, B. G., Hellingwerf, K. J., & Branco Dos Santos, F. (2018). Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth. Biotechnology for Biofuels, 11, Article 38. https://doi.org/10.1186/s13068-018-1037-8 [details]
- Lips, D., Schuurmans, J. M., Branco dos Santos, F., & Hellingwerf, K. J. (2018). Many ways towards 'solar fuel': quantitative analysis of the most promising strategies and the main challenges during scale-up. Energy and Environmental Science, 11(1), 10-22. https://doi.org/10.1039/c7ee02212c [details]
- Luimstra, V. M., Schuurmans, J. M., Verschoor, A. M., Hellingwerf, K. J., Huisman, J., & Matthijs, H. C. P. (2018). Blue light reduces photosynthetic efficiency of cyanobacteria through an imbalance between photosystems I and II. Photosynthesis Research, 138(2), 177-189. https://doi.org/10.1007/s11120-018-0561-5 [details]
- van Alphen, P., Abedini Najafabadi, H., Branco Dos Santos, F., & Hellingwerf, K. J. (2018). Increasing the Photoautotrophic Growth Rate of Synechocystis sp. PCC 6803 by Identifying the Limitations of Its Cultivation. Biotechnology Journal, 13(8), Article 1700764. https://doi.org/10.1002/biot.201700764 [details]
2017
- Carpine, R., Du, W., Olivieri, G., Pollio, A., Hellingwerf, K. J., Marzocchella, A., & Branco dos Santos, F. (2017). Genetic engineering of Synechocystis sp. PCC6803 for poly-β-hydroxybutyrate overproduction. Algal Research, 25, 117-127. https://doi.org/10.1016/j.algal.2017.05.013 [details]
- Chen, Q., Arents, J., Ganapathy, S., de Grip, W. J., & Hellingwerf, K. J. (2017). Functional Expression of Gloeobacter Rhodopsin in Synechocystis sp. PCC6803. Photochemistry and Photobiology, 93(3), 772-781. https://doi.org/10.1111/php.12745 [details]
- Du, W., Angermayr, S. A., Jongbloets, J. A., Molenaar, D., Bachmann, H., Hellingwerf, K. J., & Branco Dos Santos, F. (2017). Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803. ACS Synthetic Biology, 6(3), 395-401. https://doi.org/10.1021/acssynbio.6b00235 [details]
- Ganapathy, S., Venselaar, H., Chen, Q., de Groot, H. J. M., Hellingwerf, K. J., & de Grip, W. J. (2017). Retinal-based Proton Pumping in the Near Infrared. Journal of the American Chemical Society, 139(6), 2338–2344. https://doi.org/10.1021/jacs.6b11366 [details]
- Groot, M. L., & Hellingwerf, K. J. (2017). Photoactive Yellow Protein: Converting Light into a Metastable Structural Change. In I. Burghardt, & S. Haacke (Eds.), Ultrafast Dynamics at the Nanoscale: Biomolecules and Supramolecular Assemblies (pp. 127-166). Pan Stanford Publishing. http://www.panstanford.com/books/9789814745338.html# [details]
- Schuurmans, R. M., Matthijs, J. C. P., & Hellingwerf, K. J. (2017). Transition from exponential to linear photoautotrophic growth changes the physiology of Synechocystis sp. PCC 6803. Photosynthesis Research, 132(1), 69-82. https://doi.org/10.1007/s11120-016-0329-8 [details]
- Veetil, V. P., Angermayr, S. A., & Hellingwerf, K. J. (2017). Ethylene production with engineered Synechocystis sp PCC 6803 strains. Microbial Cell Factories, 16, Article 34. https://doi.org/10.1186/s12934-017-0645-5 [details]
2016
- Angermayr, S. A., van Alphen, P., Hasdemir, D., Kramer, G., Iqbal, M., van Grondelle, W., Hoefsloot, H. C., Choi, Y. H., & Hellingwerf, K. J. (2016). Culturing Synechocystis sp. Strain PCC 6803 with N2 and CO2 in a Diel Regime Reveals Multiphase Glycogen Dynamics with Low Maintenance Costs. Applied and Environmental Microbiology, 82(14), 4180-4189. Advance online publication. https://doi.org/10.1128/AEM.00256-16 [details]
- Chen, Q., Montesarchio, D., & Hellingwerf, K. J. (2016). ‘Direct Conversion’: Artificial Photosynthesis With Cyanobacteria. In R. Bruno (Ed.), Artificial photosynthesis (pp. 43-62). (Advances in Botanical Research; No. 79). Elsevier. https://doi.org/10.1016/bs.abr.2016.03.001 [details]
- Chen, Q., van der Steen, J. B., Dekker, H. L., Ganapathy, S., de Grip, W. J., & Hellingwerf, K. J. (2016). Expression of holo-proteorhodopsin in Synechocystis sp. PCC 6803. Metabolic Engineering, 35, 83-94. https://doi.org/10.1016/j.ymben.2016.02.001 [details]
- Choi, S., Nakasone, Y., Hellingwerf, K. J., & Terazima, M. (2016). Photochemical Reactions of the LOV and LOV-Linker Domains of the Blue Light Sensor Protein YtvA. Biochemistry, 55(22), 3107-3115. https://doi.org/10.1021/acs.biochem.6b00263 [details]
- Savakis, P., Tan, X., Qiao, C., Song, K., Hellingwerf, K. J., & Branco dos Santos, F. (2016). Slr1670 from Synechocystis sp. PCC 6803 Is Required for the Re-assimilation of the Osmolyte Glucosylglycerol. Frontiers in Microbiology, 7, Article 1350. https://doi.org/10.3389/fmicb.2016.01350 [details]
- Wareham, L. K., Begg, R., Jesse, H. E., van Beilen, J. W. A., Ali, S., Svistunenko, D., McLean, S., Hellingwerf, K. J., Sanguinetti, G., & Poole, R. K. (2016). Carbon monoxide gas is not inert, but global, in its consequences for bacterial gene expression, iron acquisition and antibiotic resistance. Antioxidants & Redox Signalling, 24(17), 1013-1028. https://doi.org/10.1089/ars.2015.6501 [details]
- van Beilen, J. W. A., & Hellingwerf, K. J. (2016). All Three Endogenous Quinone Species of Escherichia coli Are Involved in Controlling the Activity of the Aerobic/Anaerobic Response Regulator ArcA. Frontiers in Microbiology, 7, Article 1339. https://doi.org/10.3389/fmicb.2016.01339 [details]
- van der Woude, A. D., Perez Gallego, R., Vreugdenhil, A., Puthan Veetil, V., Chroumpi, T., & Hellingwerf, K. J. (2016). Genetic engineering of Synechocystis PCC6803 for the photoautotrophic production of the sweetener erythritol. Microbial Cell Factories, 15, Article 60. https://doi.org/10.1186/s12934-016-0458-y [details]
2015
- Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J. (2015). Metabolic engineering of cyanobacteria for the synthesis of commodity products. Trends in Biotechnology, 33(6), 352-361. Advance online publication. https://doi.org/10.1016/j.tibtech.2015.03.009 [details]
- Angermayr, S. A., van der Woude, A. D., Correddu, D., Kern, R., Hagemann, M., & Hellingwerf, K. J. (2015). Chirality Matters: Synthesis and Consumption of the d-Enantiomer of Lactic Acid by Synechocystis sp. Strain PCC6803. Applied and Environmental Microbiology, 82(4), 1295-1304. https://doi.org/10.1128/AEM.03379-15 [details]
- Borirak, O., Rolfe, M. D., de Koning, L. J., Hoefsloot, H. C. J., Bekker, M., Dekker, H. L., Roseboom, W., Green, J., de Koster, C. G., & Hellingwerf, K. J. (2015). Time-series analysis of the transcriptome and proteome of Escherichia coli upon glucose repression. Biochimica et Biophysica Acta. Proteins and Proteomics, 1854(10, Part A), 1269-1279. https://doi.org/10.1016/j.bbapap.2015.05.017 [details]
- Borirak, O., de Koning, L. J., van der Woude, A. D., Hoefsloot, H. C. J., Dekker, H. L., Roseboom, W., de Koster, C. G., & Hellingwerf, K. J. (2015). Quantitative proteomics analysis of an ethanol- and a lactate-producing mutant strain of Synechocystis sp. PCC6803. Biotechnology for Biofuels, 8, Article 111. https://doi.org/10.1186/s13068-015-0294-z [details]
- Ganapathy, S., Bécheau, O., Venselaar, H., Frölich, S., van der Steen, J. B., Chen, Q., Radwan, S., Lugtenburg, J., Hellingwerf, K. J., de Groot, H. J., & de Grip, W. J. (2015). Modulation of spectral properties and pump activity of proteorhodopsins by retinal analogues. Biochemical Journal, 467(2), 333-343. https://doi.org/10.1042/BJ20141210 [details]
- Hammar, P., Angermayr, S. A., Sjostrom, S. L., van der Meer, J., Hellingwerf, K. J., Hudson, E. P., & Joensson, H. N. (2015). Single-cell screening of photosynthetic growth and lactate production by cyanobacteria. Biotechnology for Biofuels, 8, Article 193. https://doi.org/10.1186/s13068-015-0380-2 [details]
- Nudel, C. B., & Hellingwerf, K. J. (2015). Photoreceptors in Chemotrophic Prokaryotes: The Case of Acinetobacter sps. Revisited. Photochemistry and Photobiology, 91(5), 1012-1020. Advance online publication. https://doi.org/10.1111/php.12491 [details]
- Savakis, P., & Hellingwerf, K. J. (2015). Engineering cyanobacteria for direct biofuel production from CO2. Current Opinion in Biotechnology, 33, 8-14. https://doi.org/10.1016/j.copbio.2014.09.007 [details]
- Schuurmans, R. M., van Alphen, P., Schuurmans, J. M., Matthijs, H. C. P., & Hellingwerf, K. J. (2015). Comparison of the Photosynthetic Yield of Cyanobacteria and Green Algae: Different Methods Give Different Answers. PLoS ONE, 10(9), Article e0139061. https://doi.org/10.1371/journal.pone.0139061 [details]
- van Alphen, P., & Hellingwerf, K. J. (2015). Sustained Circadian Rhythms in Continuous Light in Synechocystis sp. PCC6803 Growing in a Well-Controlled Photobioreactor. PLoS ONE, 10(6), e0127715. https://doi.org/10.1371/journal.pone.0127715 [details]
- van der Steen, J. B., & Hellingwerf, K. J. (2015). Activation of the General Stress Response of Bacillus subtilis by Visible Light. Photochemistry and Photobiology, 91(5), 1032-1045. https://doi.org/10.1111/php.12499 [details]
2014
- Angermayr, S. A., van der Woude, A. D., Correddu, D., Vreugdenhil, A., Verrone, V., & Hellingwerf, K. J. (2014). Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803. Biotechnology for Biofuels, 7, 99. https://doi.org/10.1186/1754-6834-7-99 [details]
- Bettenbrock, K., Bai, H., Ederer, M., Green, J., Hellingwerf, K. J., Holcombe, M., Kunz, S., Rolfe, M. D., Sanguinetti, G., Sawodny, O., Sharma, P., Steinsiek, S., & Poole, R. K. (2014). Towards a systems level understanding of the oxygen response of Escherichia coli. Advances in Microbial Physiology, 64, 65-114. https://doi.org/10.1016/B978-0-12-800143-1.00002-6 [details]
- Schuurmans, R. M., Matthijs, H. C. P., Stal, L. J., & Hellingwerf, K. J. (2014). Cyanobacterial cellulose synthesis in the light of the photanol concept. In N. K. Sharma, A. K. Rai, & L. J. Stal (Eds.), Cyanobacteria: an economic perspective (pp. 181-196). Wiley Blackwell. https://doi.org/10.1002/9781118402238.ch11 [details]
- Schuurmans, R. M., Schuurmans, J. M., Bekker, M., Kromkamp, J. C., Matthijs, H. C. P., & Hellingwerf, K. J. (2014). The redox potential of the plastoquinone pool of the cyanobacterium Synechocystis species strain PCC 6803 is under strict homeostatic control. Plant Physiology, 165(1), 463-475. https://doi.org/10.1104/pp.114.237313 [details]
2013
- Angermayr, S., & Hellingwerf, K. J. (2013). On the Use of Metabolic Control Analysis in the Optimization of Cyanobacterial Biosolar Cell Factories. The journal of Physical Chemistry. B, 117(38), 11169-11175. https://doi.org/10.1021/jp4013152 [details]
- Bitrian, M., Gonzalez, R. H., Paris, G., Hellingwerf, K. J., & Nudel, C. B. (2013). Blue-light dependent inhibition of twitching motility in Acinetobacter baylyi ADP1: Additive involvement of three BLUF domain-containing proteins. Microbiology - SGM, 159(9), 1828-1841. https://doi.org/10.1099/mic.0.069153-0 [details]
- Hospes, M., Hendriks, J., & Hellingwerf, K. J. (2013). Tryptophan fluorescence as a reporter for structural changes in photoactive yellow protein elicited by photo-activation. Photochemical & Photobiological Sciences, 12(3), 479-488. https://doi.org/10.1039/c2pp25222h [details]
- Mensonides, F. I. C., Hellingwerf, K. J., Teixeira De Mattos, M. J., & Brul, S. (2013). Multiphasic adaptation of the transcriptome of Saccharomyces cerevisiae to heat stress. Food research international, 54(1), 1103-1112. https://doi.org/10.1016/j.foodres.2012.12.042 [details]
- Savakis, P. E., Angermayr, S., & Hellingwerf, K. (2013). Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria. Metabolic Engineering, 20, 121-130. Advance online publication. https://doi.org/10.1016/j.ymben.2013.09.008 [details]
- Sharma, P., Stagge, S., Bekker, M., Bettenbrock, K., & Hellingwerf, K. (2013). Kinase activity of ArcB from Escherichia coli is subject to regulation by both ubiquinone and demethylmenaquinone. PLoS ONE, 8(10), e75412. https://doi.org/10.1371/journal.pone.0075412 [details]
- Song, S. H., Madsen, D., van der Steen, J. B., Pullman, R., Freer, L. H., Hellingwerf, K., & Larsen, D. S. (2013). Primary Photochemistry of the Dark- and Light-Adapted States of the YtvA Protein from Bacillus subtilis. Biochemistry, 52(45), 7951-7963. https://doi.org/10.1021/bi4012258 [details]
- Wijffels, R. H., Kruse, O., & Hellingwerf, K. J. (2013). Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae. Current Opinion in Biotechnology, 24(3), 405-413. https://doi.org/10.1016/j.copbio.2013.04.004 [details]
- Zhu, J., Paparelli, L., Hospes, M., Arents, J., Kennis, J. T., van Stokkum, I. H. M., Hellingwerf, K. J., & Groot, M. L. (2013). Photoionization and Electron Radical Recombination Dynamics in Photoactive Yellow Protein Investigated by Ultrafast Spectroscopy in the Visible and Near-Infrared Spectral Region. The journal of Physical Chemistry. B, 117(38), 11042-11048. https://doi.org/10.1021/jp311906f [details]
- van der Steen, J. B., Nakasone, Y., Hendriks, J. C., & Hellingwerf, K. J. (2013). Modeling the functioning of YtvA in the general stress response in Bacillus subtilis. Molecular BioSystems, 9, 2331-2343. https://doi.org/10.1039/c3mb70124g [details]
2012
- Angermayr, S. A., Paszota, M., & Hellingwerf, K. J. (2012). Engineering a cyanobacterial cell factory for production of lactic acid. Applied and Environmental Microbiology, 78(19), 7098-7106. Advance online publication. https://doi.org/10.1128/AEM.01587-12 [details]
- Hospes, M., Ippel, J. H., Boelens, R., Hellingwerf, K. J., & Hendriks, J. (2012). Binding of hydrogen-citrate to photoactive yellow protein is affected by the structural changes related to signaling state formation. The journal of Physical Chemistry. B, 116(44), 13172-13182. https://doi.org/10.1021/jp306891s [details]
- Sharma, P., Hellingwerf, K. J., Teixeira De Mattos, M. J., & Bekker, M. (2012). Uncoupling of substrate-level phosphorylation in Escherichia coli during glucose-limited growth. Applied and Environmental Microbiology, 78(19), 6908-6913. Advance online publication. https://doi.org/10.1128/AEM.01507-12 [details]
- Sharma, P., Teixeira De Mattos, M. J., Hellingwerf, K. J., & Bekker, M. (2012). On the function of the various quinone species in Escherichia coli. The FEBS Journal, 279, 3364-3373. https://doi.org/10.1111/j.1742-4658.2012.08608.x [details]
- van Roermund, C. W. T., Ijlst, L., Majczak, W., Waterham, H. R., Folkerts, H., Wanders, R. J. A., & Hellingwerf, K. J. (2012). Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae. The Journal of Biological Chemistry, 287(24), 20144-20153. https://doi.org/10.1074/jbc.M111.332833 [details]
- van der Steen, J. B., Ávila-Pérez, M., Knippert, D., Vreugdenhil, A., van Alphen, P., & Hellingwerf, K. J. (2012). Differentiation of function among the RsbR paralogs in the general stress response of Bacillus subtilis with regard to light perception. Journal of Bacteriology, 194(7), 1708-1716. https://doi.org/10.1128/JB.06705-11 [details]
2011
- Arents, J. C., Perez, M. A., Hendriks, J., & Hellingwerf, K. J. (2011). On the midpoint potential of the FAD chromophore in a BLUF-domain containing photoreceptor protein. FEBS Letters, 585(1), 167-172. https://doi.org/10.1016/j.febslet.2010.11.035 [details]
- Carroll, E. C., Hospes, M., Valladares, C., Hellingwerf, K. J., & Larsen, D. S. (2011). Is the photoactive yellow protein a UV-B/blue light photoreceptor? Photochemical & Photobiological Sciences, 10(4), 464-468. https://doi.org/10.1039/c0pp00274g [details]
- Di Donato, M., van Wilderen, L. J., van Stokkum, I. H. M., Stuart, T. C., Kennis, J. T. M., Hellingwerf, K. J., van Grondelle, R., & Groot, M. L. (2011). Proton transfer events in GFP. Physical Chemistry Chemical Physics, 13(36), 16295-16305. https://doi.org/10.1039/c1cp20387h [details]
- Nakasone, Y., & Hellingwerf, K. J. (2011). On the binding of BODIPY-GTP by the photosensory protein YtvA from the common soil bacterium Bacillus subtilis. Photochemistry and Photobiology, 87(3), 542-547. https://doi.org/10.1111/j.1751-1097.2011.00919.x [details]
- Rupenyan, A. B., Vreede, J., van Stokkum, I. H. M., Hospes, M., Kennis, J. T. M., Hellingwerf, K. J., & Groot, M. L. (2011). Proline 68 enhances photoisomerization yield in photoactive yellow protein. The journal of Physical Chemistry. B, 115(20), 6668-6677. https://doi.org/10.1021/jp112113s [details]
- Sosinska, G. J., de Koning, L. J., de Groot, P. W. J., Manders, E. M. M., Dekker, H. L., Hellingwerf, K. J., de Koster, C. G., & Klis, F. M. (2011). Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology - SGM, 157(1), 136-146. https://doi.org/10.1099/mic.0.044206-0 [details]
- Stahl, A. D., Hospes, M., Singhal, K., van Stokkum, I., van Grondelle, R., Groot, M. L., & Hellingwerf, K. J. (2011). On the involvement of single-bond rotation in the primary photochemistry of photoactive yellow protein. Biophysical Journal, 101(5), 1184-1192. https://doi.org/10.1016/j.bpj.2011.06.065 [details]
2010
- Anemaet, I. G., Bekker, M., & Hellingwerf, K. J. (2010). Algal photosynthesis as the primary driver for a sustainable development in energy, feed, and food production. Marine Biotechnology, 12(6), 619-629. https://doi.org/10.1007/s10126-010-9311-1 [details]
- Bekker, M., Alexeeva, S., Laan, W., Sawers, G., Teixeira De Mattos, J., & Hellingwerf, K. (2010). The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool. Journal of Bacteriology, 192(3), 746-754. https://doi.org/10.1128/JB.01156-09 [details]
- Metz, S., Hendriks, J., Jager, A., Hellingwerf, K., & Klug, G. (2010). In vivo effects on photosynthesis gene expression of base pair exchanges in the gene encoding the light-responsive BLUF domain of AppA in Rhodobacter sphaeroides. Photochemistry and Photobiology, 86(4), 882-889. https://doi.org/10.1111/j.1751-1097.2010.00749.x [details]
- Zakrzewska, A., Boorsma, A., ter Beek, A., Hageman, J. A., Westerhuis, J. A., Hellingwerf, K. J., Brul, S., Klis, F. M., & Smits, G. J. (2010). Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae. Omics, 14(5), 603-614. https://doi.org/10.1089/omi.2010.0049 [details]
- Ávila-Pérez, M., van der Steen, J. B., Kort, R., & Hellingwerf, K. J. (2010). Red light activates the sigma(B)-mediated general stress response of Bacillus subtilis via the energy branch of the upstream signaling cascade. Journal of Bacteriology, 192(3), 755-762. https://doi.org/10.1128/JB.00826-09 [details]
2009
- Alexandre, M. T. A., Domratcheva, T., Bonetti, C., van Wilderen, L. J. G. W., van Grondelle, R., Groot, M. L., Hellingwerf, K. J., & Kennis, J. T. M. (2009). Primary reactions of the LOV2 domain of phototropin studied with ultrafast mid-infrared spectroscopy and quantum chemistry. Biophysical Journal, 97(1), 227-237. https://doi.org/10.1016/j.bpj.2009.01.066 [details]
- Alexandre, M. T. A., van Grondelle, R., Hellingwerf, K. J., & Kennis, J. T. M. (2009). Conformational heterogeneity and propagation of structural changes in the LOV2/Jα domain from Avena sativa phototropin 1 as recorded by temperature-dependent FTIR spectroscopy. Biophysical Journal, 97(1), 238-247. https://doi.org/10.1016/j.bpj.2009.03.047 [details]
- Angermayr, S., Hellingwerf, K., Lindblad, P., & Teixeira De Mattos, J. (2009). Energy biotechnology with cyanobacteria. Current Opinion in Biotechnology, 20(3), 257-263. https://doi.org/10.1016/j.copbio.2009.05.011 [details]
- Avila-Pérez, M., Vreede, J., Tang, Y., Bende, O., Losi, A., Gärtner, W., & Hellingwerf, K. (2009). In vivo mutational analysis of YtvA from Bacillus subtilis: Mechanism of light activation of the general stress response. The Journal of Biological Chemistry, 284(37), 24958-24964. https://doi.org/10.1074/jbc.M109.033316 [details]
- Bekker, M., de Vries, S., ter Beek, A., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2009). Respiration of Escherichia coli can be fully uncoupled via the nonelectrogenic terminal cytochrome bd-II oxidase. Journal of Bacteriology, 191(17), 5510-5517. https://doi.org/10.1128/JB.00562-09 [details]
- Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2009). Alternative routes to biofuels: Light-driven biofuel formation from CO2 and water based on the ‘photanol’ approach. Journal of Biotechnology, 142(1), 87-90. https://doi.org/10.1016/j.jbiotec.2009.02.002 [details]
- Hendriks, J., & Hellingwerf, K. J. (2009). pH dependence of the photoactive yellow protein photocycle recovery reaction reveals a new late photocycle intermediate with a deprotonated chromophore. The Journal of Biological Chemistry, 284(8), 5277-5288. https://doi.org/10.1074/jbc.M805904200 [details]
- Hendriks, J., van der Horst, M. A., Chua, T. K., Ávila Pérez, M., van Wilderen, L. J., Alexandre, M. T. A., Groot, M-L., Kennis, J. T. M., & Hellingwerf, K. J. (2009). Photoreceptor proteins from purple bacteria. In C. N. Hunter, F. Daldal, M. C. Thurnauer, & J. T. Beatty (Eds.), The purple phototrophic bacteria (pp. 811-837). (Advances in photosynthesis and respiration; No. 28). Springer. https://doi.org/10.1007/978-1-4020-8815-5_41 [details]
- Hoff, W. D., van der Horst, M. A., Nudel, B. C., & Hellingwerf, K. J. (2009). Prokaryotic phototaxis. In T. Jin, & D. Hereld (Eds.), Chemotaxis: methods and protocols (pp. 25-49). (Methods in molecular biology; No. 571). Humana Press. https://doi.org/10.1007/978-1-60761-198-1_2 [details]
- Kramer, G., Sprenger, R. R., Back, J. W., Dekker, H. L., Nessen, M. A., van Maarseveen, J. H., de Koning, L. J., Hellingwerf, K. J., de Jong, L., & de Koster, C. G. (2009). Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography. Molecular & Cellular Proteomics, 8(7), 1599-1611. https://doi.org/10.1074/mcp.M800392-MCP200 [details]
- Rupenyan, A., van Stokkum, I. H. M., Arents, J. C., van Grondelle, R., Hellingwerf, K. J., & Groot, M. L. (2009). Reaction pathways of photoexcited retinal in proteorhodopsin studied by pump-dump-probe spectroscopy. The journal of Physical Chemistry. B, 113(50), 16251-16256. https://doi.org/10.1021/jp9065289 [details]
- Rzeźnicka, I. I., Wurpel, G. W. H., Bonn, M., van der Horst, M. A., Hellingwerf, K. J., Matsunaga, S., Yamada, T., & Kawai, M. (2009). Observation of photoactive yellow protein anchored to a modified Au(1 1 1) surface by scanning tunneling microscopy. Chemical Physics Letters, 472(1-3), 113-117. https://doi.org/10.1016/j.cplett.2009.02.067 [details]
- van der Horst, M. A., Stalcup, T. P., Kaledhonkar, S., Kumauchi, M., Hara, M., Xie, A., Hellingwerf, K. J., & Hoff, W. D. (2009). Locked chromophore analogs reveal that photoactive yellow protein regulates biofilm formation in the deep sea bacterium Idiomarina loihiensis. Journal of the American Chemical Society, 131(47), 17443-17451. https://doi.org/10.1021/ja9057103 [details]
2008
- Alexandre, M. T. A., van Grondelle, R., Hellingwerf, K. J., Robert, B., & Kennis, J. T. M. (2008). Perturbation of the ground-state electronic structure of FMN by the conserved cysteine in phototropin LOV2 domains. Physical Chemistry Chemical Physics, 10(44), 6693-6702. https://doi.org/10.1039/b810040c [details]
- Brul, S., Mensonides, F. I. C., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Microbial systems biology: New frontiers open to predictive microbiology. International Journal of Food Microbiology, 128(1), 16-21. https://doi.org/10.1016/j.ijfoodmicro.2008.04.029 [details]
- Lee, J., Tomchick, D. R., Brautigam, C. A., Machius, M., Kort, R., Hellingwerf, K. J., & Gardner, K. H. (2008). Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochemistry, 47(13), 4051-4064. https://doi.org/10.1021/bi7021156 [details]
- Rupenyan, A., van Stokkum, I. H. M., Arents, J. C., van Grondelle, R., Hellingwerf, K., & Groot, M. L. (2008). Characterization of the primary photochemistry of proteorhodopsin with femtosecond spectroscopy. Biophysical Journal, 94(10), 4020-4030. https://doi.org/10.1529/biophysj.107.121376 [details]
- Schuurmans, J. M., Boorsma, A., Lascaris, R., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Physiological and transcriptional characterization of Saccharomyces cerevisiae strains with modified expression of catabolic regulators. FEMS Yeast Research, 8(1), 26-34. https://doi.org/10.1111/j.1567-1364.2007.00309.x [details]
- Schuurmans, J. M., Rossell, S. L., van Tuijl, A., Bakker, B. M., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Effect of hxk2 deletion and HAP4 overexpression on fermentative capacity in Saccharomyces cerevisiae. FEMS Yeast Research, 8(2), 195-203. https://doi.org/10.1111/j.1567-1364.2007.00319.x [details]
- Sosinska, G. J., de Groot, P. W. J., Teixeira De Mattos, M. J., Dekker, H. L., de Koster, C. G., Hellingwerf, K. J., & Klis, F. M. (2008). Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology - SGM, 154(2), 510-520. https://doi.org/10.1099/mic.0.2007/012617-0 [details]
- Toh, K. C., van Stokkum, I. H. M., Hendriks, J., Alexandre, M. T. A., Arents, J. C., Avila Perez, M., van Grondelle, R., Hellingwerf, K. J., & Kennis, J. T. M. (2008). On the signaling mechanism and the absence of photoreversibility in the AppA BLUF domain. Biophysical Journal, 95(1), 312-321. https://doi.org/10.1529/biophysj.107.117788 [details]
- Vreede, J., Hellingwerf, K. J., & Bolhuis, P. G. (2008). Helix formation is a dynamical bottleneck in the recovery reaction of Photoactive Yellow Protein. Proteins, 72(1), 136-149. https://doi.org/10.1002/prot.21902 [details]
- Vreede, J., Hellingwerf, K. J., & Crielaard, W. (2008). TraR auto-inducer enhances protein backbone fluctuations in DNA binding domain. FEBS Letters, 582(5), 805-809. https://doi.org/10.1016/j.febslet.2008.01.062 [details]
2015
- Savakis, P., Tan, X., Du, W., Branco dos Santos, F., Lu, X., & Hellingwerf, K. J. (2015). Photosynthetic production of glycerol by a recombinant cyanobacterium. Journal of Biotechnology, 195, 46-51. Advance online publication. https://doi.org/10.1016/j.jbiotec.2014.12.015 [details]
- Zhu, J., Vreede, J., Hospes, M., Arents, J., Kennis, J. T. M., van Stokkum, I. H. M., Hellingwerf, K. J., & Groot, M. L. (2015). Short Hydrogen Bonds and Negative Charge in Photoactive Yellow Protein Promote Fast Isomerization but not High Quantum Yield. The journal of Physical Chemistry. B, 119(6), 2372-2383. https://doi.org/10.1021/jp506785q [details]
2014
- Borirak, O., Bekker, M., & Hellingwerf, K. J. (2014). Molecular physiology of the dynamic regulation of carbon catabolite repression in Escherichia coli. Microbiology - SGM, 160(6), 1214-1223. Advance online publication. https://doi.org/10.1099/mic.0.077289-0 [details]
- Branco dos Santos, F., Du, W., & Hellingwerf, K. J. (2014). Synechocystis: not just a plug-bug for CO2, but a green E. coli. Frontiers in Bioengineering and Biotechnology, 2, Article 36. https://doi.org/10.3389/fbioe.2014.00036 [details]
- Bury, A., & Hellingwerf, K. J. (2014). On the in vivo redox state of flavin-containing photosensory receptor proteins. In S. Weber, & E. Schleicher (Eds.), Flavins and Flavoproteins: Methods and Protocols (pp. 177-190-9). (Methods in Molecular Biology; No. 1146). Humana Press. https://doi.org/10.1007/978-1-4939-0452-5_9 [details]
- Mensonides, F. I. C., Brul, S., Hellingwerf, K. J., Bakker, B. M., & Teixeira De Mattos, M. J. (2014). A kinetic model of catabolic adaptation and protein reprofiling in Saccharomyces cerevisiae during temperature shifts. The FEBS Journal, 281(3), 825-841. https://doi.org/10.1111/febs.12649 [details]
- van Beilen, J. W. A., Teixeira De Mattos, M. J., Hellingwerf, K. J., & Brul, S. (2014). Distinct Effects of Sorbic Acid and Acetic Acid on the Electrophysiology and Metabolism of Bacillus subtilis. Applied and Environmental Microbiology, 80(19), 5918-5926. https://doi.org/10.1128/AEM.01391-14 [details]
- van der Woude, A. D., Angermayr, S. A., Puthan Veetil, V., Osnato, A., & Hellingwerf, K. J. (2014). Carbon sink removal: Increased photosynthetic production of lactic acid by Synechocystis sp. PCC6803 in a glycogen storage mutant. Journal of Biotechnology, 184, 100-102. Advance online publication. https://doi.org/10.1016/j.jbiotec.2014.04.029 [details]
2011
- Hendriks, J., Hospes, M., & Hellingwerf, K. J. (2011). Photoactive yellow protein, the prototype Xanthopsin. In H. W. Lenci, F. (Ed.), CRC Handbook of Organic Photochemistry and Photobiology (pp. 1137-1160). CRC Press. https://doi.org/10.1201/9780203495902.ch123 [details]
2016
- Hellingwerf, K. J., van Lieshout, T., Koblens, P., van Grondelle, W., & van Alphen, P. (2016). Arrangement of a photobioreactor or a microbiological reactor.
2015
- Hellingwerf, K. J. (2015). Cultures- Microbes + Climate Change. ASM (American Society of Microbiology). http://www.mzines.net/publications/1197/p/mxw_ASM_Cultures_V2I4_flipbook_20160112-Optimized_v4.pdf
- Hellingwerf, K. J. (2015). Interview Gijs den Brinker: ‘Brandstof uit bacteriën: groen en gewild maar nog niet goedkoop’. Financieel dagblad. http://fd.nl/ondernemen/1093608/brandstof-uit-bacterien-groen-gewild-maar-nog-niet-goedkoop
- Hellingwerf, K. J. (2015). Interview door Franka Rolvink Couzy: "De geldwolven van de wetenschap doen gewoon hun werk". Financieel dagblad. http://fd.nl/economie-politiek/1097293/de-geldwolven-van-de-wetenschap-doen-gewoon-hun-werk
2014
- Hellingwerf, K. J. (2014). Chemische Feitelijkheden - Fotosynthese 2.0. Chemische Feitelijkheden, 75(308). http://www.chemischefeitelijkheden.nl/colofon-chemische-feitelijkheden.59438.lynkx
2013
- Borirak, O., Bekker, M., Rolfe, M. D., Dekker, H. L., de Jong, L., de Koster, C. G., Hoefsloot, H. C. J., de Koning, L. J., & Hellingwerf, K. J. (2013). Dynamic changes of the Escherichia coli transcriptome and proteome exerted by glucose repression. The FASEB Journal, 27(1 Supplement), Article lb136. http://www.fasebj.org/content/27/1_Supplement/lb136.abstract [details]
2017
- Chen, Q. (2017). Engineering retinal-based phototrophy via a complementary photosystem in Synechocystis sp. PCC6803. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Schuurmans, R. M. (2017). Physiological and genetic studies towards biofuel production in cyanobacteria. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2021
- Frehan, S., de Groot, H. J. M., Kennis, J. T. M., Hellingwerf, K. J., Chen, Q., Hontani, Y., de Grip, W. J., Opdam, L. & Ganapathy, S. (26-4-2021). Data for: Membrane matters: The impact of a nanodisc-bilayer or a detergent microenvironment on the properties of two eubacterial rhodopsins. Mendeley Data. https://doi.org/10.17632/3mfgrjx2bx.1
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Photanol BV
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Photanol BV
Carpine, R., Olivieri, G., Hellingwerf, K. J., Pollio, A., & Marzocchella, A. (2020). Industrial Production of Poly-β-hydroxybutyrate from CO2: Can Cyanobacteria Meet this Challenge? Processes, 8(3), Article 323.