Photographer: Liesbeth Dingemans

dr. R. (Renée) van Amerongen


  • Faculty of Science
    Swammerdam Institute for Life Sciences
  • Visiting address
    Science Park A
    Science Park 904  Room number: C2.261
  • Postal address:
    Postbus  94215
    1090 GE  Amsterdam
  • R.vanAmerongen@uva.nl
    T: 0205255682

Work experience

2017 - present: associate professor (tenured) 

2013 - 2017: MacGillavry fellow and tenure track assistant professor at the University of Amsterdam

2011 - 2013: senior postdoc with prof.dr. Daniel Peeper at the Netherlands Cancer Institute

2008 - 2011: postdoc with prof.dr. Roel Nusse at Stanford University, USA

1999 - 2005: PhD thesis research with prof.dr. Anton Berns at the Netherlands Cancer Institute 

 

Education

2005 PhD (cum laude) from the Universiteit van Amsterdam

1999 MSc (cum laude) from the  Vrije Universiteit Amsterdam

 

Honors and Awards

2014 NWO VIDI grant

2013 NWO Aspasia (declined)

2013 KWF persoonsgebonden financiering

2013  MacGillavry fellowship

2007 4-year KWF fellowship for fundamental cancer research 

2007 longterm EMBO fellowship 

Cells are the building blocks of the human body.

 

 

Development of a multicellular organism requires tight control of cell proliferation, differentiation and polarized cell movements to ensure the correct assembly of cells into complex tissues. But how does a single fertilized oocyte ultimately grow out into a complex animal with billions of specialized cells that carry out very different functions? And how is tissue function and integrity maintained in the adult? These are central questions in biology.

 

 

The same molecular mechanisms that normally guide these biological processes in the developing embryo, maintain tissue homeostasis in the adult. When disrupted, they are the underlying cause of degenerative diseases, tumor formation and, ultimately, aging.

My goal is to translate principles of developmental and stem cell biology to cancer research and regenerative medicine. In this, I combine my background in molecular genetics and oncology with my experience in developmental biology and stem cell research. Focusing on Wnt signal transduction in the context of mammary gland development and breast cancer, my research team aims to understand the molecular mechanisms that control complex and dynamic cell behavior in development and disease.

 

For more information, visit our lab website

All multicellular animals use Wnt signal transduction as a molecular mechanism to control cell division, differentiation and movement. How this pathway operates at the molecular level to control complex cell behavior in 3D space and time remains incompletely understood.

2017

  • van de Moosdijk, A. A. A., Fu, N. Y., Rios, A. C., Visvader, J. E., & van Amerongen, R. (2017). Lineage Tracing of Mammary Stem and Progenitor Cells. Methods in Molecular Biology, 1501, 291-308. DOI: 10.1007/978-1-4939-6475-8_15  [details] 

2016

2015

  • van Amerongen, R. (2015). Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles. In M. Vivanco del Mar (Ed.), Mammary Stem Cells: methods and protocols (pp. 187-211). (Methods in Molecular Biology; No. 1293). New York: Humana Press. DOI: 10.1007/978-1-4939-2519-3_11  [details] 
  • Glukhova, M. A., Hynes, N., Vivanco, DM., van Amerongen, R., Clarke, R. B., & Bentires-Alj, M. (2015). The seventh ENBDC workshop on methods in mammary gland development and cancer. Breast Cancer Research, 17, [119]. DOI: 10.1186/s13058-015-0629-5  [details] 

2014

2013

  • Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., Kuo, C. J., ... Nusse, R. (2013). Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science, 342(6163), 1226-1230. DOI: 10.1126/science.1239730  [details] 
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library  or the Pure staff  of your faculty / institute. Log in to Pure  to edit your publications. Log in to Personal Page Publication Selection tool  to manage the visibility of your publications on this list.
  • No ancillary activities

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