Manager Immunopathologie at Sanquin Research, Amsterdam, The Netherlands
The Department of Immunopathology investigates the regulation of inflammation and tolerance against non-infectious antigens, with a specific focus on humoral immune responses.
Head Division Immunology at the Netherlands Cancer Institute, Amsterdam, The Netherlands
"Our research addresses the question how lymphocytes decide between living and dying. Our work is inspired by the desire to improve immunotherapy of cancer. Sustaining survival of activated lymphocytes is expected to improve anti-tumor immunity. The second aim of our work is to contribute to the design of novel anti-cancer therapies by exploiting apoptotic pathways."
Special Chair: Molecular Cell Biology of Cell Migration
Affiliated to: Molecular Cytology
Project leader at the John Innes Centre, Norwich, UK
Saskia Hogenhout’s research focuses on understanding the mechanisms that drive interactions between plants and insects and the role of microbes in these interactions. She is particularly interested in aphids, whiteflies, leafhoppers and other sap-feeding insects of the order Hemiptera. The saliva of these insects contains virulence factors (effectors) that modulate plant responses and aid insect colonisation. The research focuses on the identification and functional analysis of these insect effectors and on finding their targets in the plant.
Senior Scientist Industrial Microbial Biotechnology in the Business Unit Biobased Products, Wageningen University & Research Centre
"Our research has two main focuses: (i) to gain complete control of the (food) fermentation processes by using a systems biology approach for complete understanding of the lactic acid bacteria and (ii) to expand the industrial use of fermentation processes as a natural and sustainable alternative for the food industry."
Affiliated to: Molecular Microbial Physiology
Group leader Cell Biophysics & Imaging Group at the Netherlands Cancer Institute, Amsterdam, the Netherlands
Genomic- and high-throughput screening methods have identified tremendous amounts of biomedically relevant proteins. The functions of these proteins can not be fully understood without detailed knowledge of their localisation, concentration, and particularly, their mutual interactions and activation state in living cells. Many of these interactions are short-lived or exist very locally within the cell and therefore techniques with high spatiotemporal resolution are required to study them in single living cells. Our lab focuses on biophysical techniques to provide this resolution. Our lab is well-equipped for both electrophysiological and advanced biophotonic studies, and we develop and implement new techniques.
Affiliated to: Molecular Cytology
Special Chair: Microbial Food Safety and Antibiotic Resistance in the Food Chain
Senior advisor microbiology at the Netherlands Food and Consumer Product Safety Authority, Ministry of Economic Affairs
All bacteria, pathogenic commensal or environmental, that are exposed to non-lethal concentrations of antibiotics acquire resistance to these compounds. Antibiotic resistance causes considerable extra costs and suffering in human patients. Some of the resistance encountered in human pathogens has originally been selected for in the agricultural sector. Our group studies in laboratory models such as chemostats how bacteria become resistant to antibiotics, what exposure regimes lead to how much resistance and how therapeutic goals can be reached while creating minimal resistance.
Affiliated to: Molecular Biology and Microbial Food Safety
Vice President Vegetable Crops at KeyGene, Wageningen, The Netherlands
"In my research chair, I focus on the interplay between plants and plant viruses. How can tiny viruses - often encoding not more than five proteins - carry out all the many complex functions that are needed for their own reproduction and spread and deal with plant defenses at the same time?"
Affiliated to: Molecular Plant Pathology