prof. dr. S.M. (Marieke) van Ham
Manager Immunopathologie at Sanquin Research, Amsterdam, The Netherlands
The Department of Immunopathology investigates the regulation of inflammation and tolerance against non-infectious antigens, with a specific focus on humoral immune responses.
prof. dr. R. (Roel) Nusse
Head of the Nusse Laboratory, Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, USA
Our laboratory is interested in the growth, development and integrity of animal tissues. We study multiple different organs, trying to identify common principles, and we extend these investigations to cancer and injury repair. In most organs, different cell types are generated by stem cells - cells that also make copies of themselves and thereby maintain the tissue. An optimal balance between the number of stem and differentiated cells is essential for the proper function of the organs. Locally-acting signals are important to maintain this balance in a spatially-organized manner and these signals are key to understanding the regulation of growth.
prof. dr. A.P. (Arie) Otte
Principal Investigator/Staff Member at the Pathology Department, Academic Medical Centre, Amsterdam, The Netherlands
Recent work on neuro-glial cell physiology has revealed that glial cells are much more actively involved in brain information processing than previously anticipated. This finding has stimulated the novel view that the brain should be viewed as a circuit of interactive neuron and glial cell networks. Despite the solidity of the evidence for glia-neuron signalling many fundamental
questions on the basic cellular and molecular aspects of this intriguing partnership still remain unanswered or have not been addressed in the functional in vivo context. The major aim of our research efforts is to investigate the role of glial cells as potential cellular targets for developing novel therapies in human neurological disorders.
Affiliated to: Cellular and Systems Neurobiology
prof. dr. J. (Jannie) Borst
Head Division Immunology at the Netherlands Cancer Institute, Amsterdam, The Netherlands
Our research addresses the question how lymphocytes decide between living and dying. Our work is inspired by the desire to improve immunotherapy of cancer. Sustaining survival of activated lymphocytes is expected to improve anti-tumor immunity. The second aim of our work is to contribute to the design of novel anti-cancer therapies by exploiting apoptotic pathways.
prof. dr. E.M. (Elly) Hol
Principal researcher of Glia in health and disease at the Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands
Astrocytes outnumber neurons in the brain, but were neglected in neuroscience research for many years. It is now recognised that astrocytes regulate local microcirculation, modulate the communication between neurons and are the stem cells in the adult brain. In Alzheimer and Parkinson patients, astrocytes become reactive which is likely to affect brain functioning. The main aim of our research is to understand the molecular and functional changes in reactive astrocytes and to study the regenerative potential of the astrocytic stem cells in neurodegeneration. We are studying the function of intermediate filament proteins, such as GFAP, which are highly regulated cytoskeletal structures with a major role in astrocytic cell signaling. The ultimate goal of our research is to develop therapeutic strategies to control reactive gliosis and to stimulate the endogenous repair capacity of the astrocytic stem cells in neurodegenerative diseases.
Affiliated to: Cellular and Systems Neurobiology
prof. dr. J. (Jeroen) Hugenholtz
Senior Scientist Industrial Microbial Biotechnology in the Business Unit Biobased Products, Wageningen University & Research Centre
Our research has two main focuses: (i) to gain complete control of the (food) fermentation processes by using a systems biology approach for complete understanding of the lactic acid bacteria and (ii) to expand the industrial use of fermentation processes as a natural and sustainable alternative for the food industry.
Affiliated to: Molecular Microbial Physiology
prof. dr. C. (Kees) Jalink
Group leader Cell Biophysics & Imaging Group at the Netherlands Cancer Institute, Amsterdam, the Netherlands
Genomic- and high-throughput screening methods have identified tremendous amounts of biomedically relevant proteins. The functions of these proteins can not be fully understood without detailed knowledge of their localisation, concentration, and particularly, their mutual interactions and activation state in living cells. Many of these interactions are short-lived or exist very locally within the cell and therefore techniques with high spatiotemporal resolution are required to study them in single living cells. Our lab focuses on biophysical techniques to provide this resolution. Our lab is well-equipped for both electrophysiological and advanced biophotonic studies, and we develop and implement new techniques.
Affiliated to: Molecular Cytology
prof. dr. O. (Ole) Jensen
Principal researcher of the
Neuronal Oscillations group, Donders Institute for Brain, Cognition and Behaviour,
Radboud University Nijmegen, The Netherlands
The main goal of the 'Neuronal Oscillations' research group is to understand how oscillatory activity shapes the functional architecture of the working brain during cognitive processing.
Affiliated to: Cognitive and Systems Neuroscience
Head Bioinformatics Laboratory at the Academic Medical Centre, Amsterdam, The Netherlands
His primary research comprises Systems Genomics and Systems Medicine with a special interest in the analysis and mathematical modelling of immune responses. Current work involves the (multiscale) modelling of the germinal center reaction during a B cell response. Other research projects include information management with a focus on knowledge bases and application of public biological databases, and e-Science with a focus on research data management. In a recently granted EU project (EpiPredict) he will develop a tamoxifen resistance knowledge base. Van Kampen is also responsible for the AMC bioinformatics research facility which provides support to AMC research groups. Finally, he is involved in a large range of bioinformatics/systems biology teaching activities including medical informatics program (AMC), AMC Graduate School, biomedical sciences (SILS), computational sciences (Institute for Informatics, UvA), and Bioinformatics and Systems Biology (VU University Amsterdam).
Affiliated to: Biosystems Data Analysis
prof. dr. ing. J.J.B. (Joost) Keurentjes
Associate Professor at the Laboratory of Genetics, Plant Genetics and Cytogenetics
Wageningen University, Wageningen, The Netherlands
The Laboratory of Genetics investigates causes and consequences of natural genetic variation within species. Genetic variation plays an essential role in ecological and evolutionary processes but is also the basis for agricultural breeding and crop improvement. Our research focuses on the use and development of genetic resources to understand the mechanistic basis of plant development and performance and elucidating the regulatory pathways governing these processes.
Affiliated to: Plant Physiology
prof. dr. B.H. (Benno) ter Kuile
Senior advisor microbiology at the Netherlands Food and Consumer Product Safety Authority, Ministry of Economic Affairs
All bacteria, pathogenic commensal or environmental, that are exposed to non-lethal concentrations of antibiotics acquire resistance to these compounds. Antibiotic resistance causes considerable extra costs and suffering in human patients. Some of the resistance encountered in human pathogens has originally been selected for in the agricultural sector. Our group studies in laboratory models such as chemostats how bacteria become resistant to antibiotics, what exposure regimes lead to how much resistance and how therapeutic goals can be reached while creating minimal resistance.
Affiliated to: Molecular Biology and Microbial Food Safety
prof. dr. M.W. (Marcel) Prins
Vice President Vegetable Crops at KeyGene, Wageningen, The Netherlands
In my research chair, I focus on the interplay between plants and plant viruses. How can tiny viruses - often encoding not more than five proteins - carry out all the many complex functions that are needed for their own reproduction and spread and deal with
plant defenses at the same time?
Affiliated to: Molecular Plant Pathology