Swammerdam Institute for Life Sciences

Research line dr. ir. J. (Joachim) Goedhart and dr. ir. M.A.(Mark) Hink

Spatial organisation of sub-cellular signallin

By employing genetic encoded fluorescent biosensors we analyse the in situ molecular interactions between signalling molecules (phospholipid-second messengers, receptors, G-proteins and effector molecules) & flow of information across and in the plane of the membrane of living mammalian cells. We aim to understand how cells can achieve and maintain a local signal in the membrane (e.g. in order to drive morphogenesis, or to define new cytoskeletal anchorage or vesicle-docking sites).

11 April 2014