Mass Spectrometry of Biomacromolecules

Group leader prof. Chris de Koster

Future progress in the life sciences will heavily depend on the integration of chemistry, physics, mathematics, (bio)informatics and biology. Our group combines mass spectrometry with biomolecular and organic chemistry. We focus on four research themes that are carried out in close collaboration with other groups within and beyond the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam.

Our research themes adhere to the study of molecular microbiology and to green life sciences. We study (i) the spore proteome of Bacilli and Clostridia, (ii) 3-D structures of protein complexes, (iii) multi-level control of gene expression regulation and (iv) isotope fractionation in plants and the geographical distribution of isotope ratio’s in horticulture products. MSB develops advanced and innovative, mass spectrometry-based proteomics-technology that is designed for these research areas and that is widely applicable in the fields of molecular and structural biology and plant biology. Here, we have long term collaborations with the SILS plant groups.

Instrumentation Mass Spectrometry of Biomacromolecules

Fourier transform ion cyclotron resonance mass spectrometer

The mass spectrometry group aims at maintaining a state-of-the-art equipped mass spectrometry laboratory in pace with the newest instrumental developments for sample pre-treatment, multi dimensional separation, mass analysis and sequence analysis of minute amounts of protein samples from complex biomatrices. Within the setting of the Swammerdam Institute and the department of Chemistry of the University of Amsterdam we make our expertise available for a protein mass spectrometry facility. The access to our in-house facility is not restricted to UvA groups and we have an open policy for collaborative projects with the Academic Medical Center, BioCentrumAmsterdam, NSBI, Free University of Amsterdam and other national and international partners.

Published by  Swammerdam Institute

29 October 2015