Swammerdam Institute for Life Sciences

Research line dr. T. (Tanneke) den Blaauwen

Molecular dynamics of the bacterial cell cycle

The morphology of rod shaped bacteria is achieved through two very dynamic synthetic complexes: the elongasome and the divisome. The elongasomes use the actin-like cytoskeleton MreB helix underneath the plasma membrane as tracking devise to elongate the cell envelope whereas the divisome is responsible for division and the synthesis of new cell poles. Cell division is directed by the FtsZ ring (a tubulin homolog) that exerts a small force on the bacterial envelope. The assembly and the dynamics of the elongasome and divisome are studied in vivo using immunofluorescence and fluorescence microscopy techniques (FRET, FRAP, localisation) and in vitro using state of the art biochemical and biophysical techniques. By aiming to obtain quantitative data, we hope to model the measured and observed interactions.

  • dr. T. (Tanneke) den Blaauwen

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    T.denBlaauwen@uva.nl | T: 0631978136

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19 March 2013