Systems Biology seminar

20June2018 16:00 - 17:00


by Johan R. C. van der Maarel

The role of SreA-mediated iron regulation in maintaining endophyte-grass symbioses.”

by Johan R. C. van der Maarel

National University of Singapore


DNAs, or sections thereof, are often interwound in closed circular form. Furthermore, they are also often crowded by other biomacromolecules (including DNAs) or simply by the fact that they are accommodated within a small volume. Both the closed circular conformation and crowding have profound effects on DNA compaction and flow. In my talk, I will first address the effect of crowding on the compaction of supercoiled DNA. With light and neutron scattering I will show that supercoiling restrains rather than facilitates compaction of crowded DNA. In the second part of my talk, I will discuss the effect of the closed circular conformation on the flow of DNA. In particular, with rheology experiments I will show that anti-cancer therapeutics targeting DNA cutting enzymes results in gelation and thereby prevents spurious cell division.


  • Science Park 904

    Science Park 904 | 1098 XH Amsterdam
    +31 (0)20 525 8626

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  • prof. dr. H.V. (Hans) Westerhoff

    host | T: 0205255150

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Published by  Swammerdam Institute