Role of balanced positive and negative feedbacks in inflammatory/infectious diseases and their treatments
Systems Biology seminar
Faculty of Engineering, Department of Bioengineering
Imperial College London
Homeostasis in biological systems is often attained as a result of a subtle balance between positive and negative feedbacks, and their unbalance may lead to disease conditions. Our research aims to elucidate essential pathological mechanisms of inflammatory and infectious disease from a viewpoint of control engineering, and to design personalised effective treatment strategies for its prevention and adequate control. In this seminar, I will present our approach applied to understand the pathogenesis for atopic eczema (acute/chronic skin inflammation with defective skin barrier) and bacterial/fungal infection in the respiratory systems. For each of the disease, we developed a simple mechanistic ODE model that describes the balanced positive and negative feedbacks that dictate the disease pathogenesis, and compared and validated our model results with experimental and clinical data.
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2. E Domínguez-Hüttinger, P Christodoulides, K Miyauchi, AD Irvine, M Okada-Hatakeyama, M Kubo and R.J. Tanaka (2017). Mathemtaical modelling of atopic dermatitis reveals "double switch'' mechanisms underlying 4 common disease phenotypes. J. Allergy Clin. Immunol. In press.
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